Description

This volume addresses a variety of areas in which computers are used to manage and manipulate nucleic acid and protein sequence data. The manipulations include searching, aligning, and determining the significance of similarities, as well as the construction of phylogenetic trees that show the evolutionary history of related sequences. Ready-to-use methods for the "at-the-bench" scientist are presented.

Readership

Biochemists, molecular biologists, evolutionary biologists, geneticists, cell biologists, and biotechnologists.

Table of Contents

Databases: C. Burks et al. , GenBank: Current Status and Future Directions. P. Kahn and G. Cameron, EMBL Data Library. W.C. Barker, D.G. George, and L.T. Hunt, Protein Sequence Database. B. Keil, Cooperation between Databases and Scientific Community. Searching Databases: W.R. Pearson, Rapid and Sensitive Sequence Comparison with FASTP and FASTA. R.F. Doolittle, Searching through Sequence Databases. S. Henikoff, J.C. Wallace, and J.P. Brown, Finding Protein Similarities with Nucleotide Sequence Databases. C.B. Lawrence, Use of Homology Domains in Sequence Similarity Detection. M. Gribskov, R. L~aduthy, and D. Eisenberg, Profile Analysis. Patterns in Nucleic Acid Sequences: R. Staden, Finding Protein Coding Regions in Genomic Sequences. J.C.W. Shepherd, Ancient Patterns in Nucleic Acid Sequences. R. Staden, Searching for Patterns in Protein and Nucleic Acid Sequences. G.D. Stormo, Consensus Patterns in DNA. M.S. Waterman and R. Jones, Consensus Methods for DNA and Protein Sequence Alignment. J.-M. Claverie, I. Sauvaget, and L. Bougueleret, k-Tuple Frequency Analysis: From Intron/Exon Discrimination to T-Cell Epitope Mapping. P. Senapathy, M.B. Shapiro, and N.L. Harris, Splice Junctions, Branch Point Sites, and Exons: Sequence Statistics, Identification, and Applications to Genome Project. Predicting RNA Secondary Structures: J.A. Jaeger, D.H. Turner, and M. Zuker, Predicting Optimal and Suboptimal Secondary Structure for RNA. H.M. Martinez, Detecting Pseudoknot

Details

No. of pages:
736
Language:
English
Copyright:
© 1990
Published:
Imprint:
Academic Press
eBook ISBN:
9780080883007
Print ISBN:
9780121820848

About the serial-volume-editor

Russell Doolittle

Affiliations and Expertise

Center for Molecular Genetics, University of California at San Diego, La Jolla, U.S.A.

Reviews

@from:Praise for the Volume @qu:"This contribution is really innovating in the domain of molecular biology and we can only congratulate the authors to have, all together, thrown such a coherent vision over these problems, since the book seems written from one and unique person, aspect which is very seldom." @source:--CELLULAR AND MOLECULAR BIOLOGY @from:Praise for the Series @qu:"The Methods in Enzymology series represents the gold-standard." @source:--NEUROSCIENCE @qu:"Incomparably useful." @source:--ANALYTICAL BIOCHEMISTRY @qu:"It is a true 'methods' series, including almost every detail from basic theory to sources of equipment and reagents, with timely documentation provided on each page." @source:--BIO/TECHNOLOGY @qu:"The series has been following the growing, changing and creation of new areas of science. It should be on the shelves of all libraries in the world as a whole collection." @source:--CHEMISTRY IN INDUSTRY @qu:"The appearance of another volume in that excellent series, Methods in Enzymology, is always a cause for appreciation for those who wish to successfully carry out a particular technique or prepare an enzyme or metabolic intermediate without the tiresome prospect of searching through unfamiliar literature and perhaps selecting an unproven method which is not easily reproduced." @source:--AMERICAN SOCIETY OF MICROBIOLOGY NEWS @qu:"If we had some way to find the work most often consulted in the laboratory, it could well be the multi-volume series Methods in Enzymology...a great work." @source:--ENZYMOLOGIA @qu:"A series that has established itself as a definitive reference for biochemists." @source:--JOURNAL OF CHROMATOGRAPHY