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Molecular Diversity and Combinatorial Chemistry - 1st Edition - ISBN: 9780080444932, 9780080913902

Molecular Diversity and Combinatorial Chemistry, Volume 24

1st Edition

Principles and Applications

Author: Michael Pirrung
Hardcover ISBN: 9780080444932
eBook ISBN: 9780080913902
Imprint: Elsevier Science
Published Date: 11th September 2004
Page Count: 188
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Table of Contents

Nature: The Original Combinatorial Chemist Biopolymers constitute natural libraries

Selection and evolution
The expression of genetic information
Combinatorial assembly of antibody genes
Molecular solutions to combinatorial problems
Synthetic Peptide Libraries Solid-phase peptide synthesis
Peptides on pins
Other iterative deconvolution strategies
Examples of split/couple/mix peptide libraries
Positional scanning
Supports, Linkers, and Reagents for Peptide Synthesis Polystyrenes
PEG-grafted supports
Coupling strategies
Supports and Linkers for Small Molecule Synthesis New resins and linkers
Ring-forming cleavage

Encoded Combinatorial Chemistry Directed Sorting Unnatural Oligomers for Library Synthesis Peptoids
Peptidyl phosphonates
Analytical Methods for Solid-phase Synthesis Product identification
Gel-phase NMR
High-resolution magic angle spinning NMR
On-bead infrared spectroscopy
Mass spectrometry
Non-spectroscopic methods
Supported Solution-phase Synthesis Polyethylene glycols
Fluorous synthesis
Solution-phase Parallel Synthesis Scavenging resins
Ion-exchange resins
Supported reagents
Fluorous reagents
Solid-phase extraction
Gas-phase separation
Multi-component Reactions Chemical Informatics, Diversity, and Library Design Strategies
Representative flowchart for a library design
Lipinski's Rules
Nucleic Acid Microarrays Combinatorial Materials Chemistry
Combinatorial Catalyst Discovery Peptides on Phage Applications of phage display
Nucleic Acid Selection Complex Combinatorial and Solid-phase Synthesis Epibatidine
The Big Picture


The field of combinatorial chemistry has seen tremendous growth over the past decade, with a prominence that suggests it will have a continuing impact.

Volume 24 in the Tetrahedron Organic Chemistry Series represents new approaches to solving problems in chemical reactivity and function. Molecular Diversity and Combinatorial Chemistry emphasises principles and exemplifies these with examples drawn from recent literature and thus is an excellent guide to the conceptual framework of the field.

The textbook includes exercises and worked problems which can provide more independent learning experiences and can also be used by an instructor leading a class on this topic.

This volume has been written with the advanced undergraduate and graduate student in mind.

Key Features

  • Concept-based
  • Includes exercises
  • Suitable for self-study


Advanced undergraduate students or graduate students


No. of pages:
© Elsevier Science 2004
11th September 2004
Elsevier Science
Hardcover ISBN:
eBook ISBN:

Ratings and Reviews

About the Author

Michael Pirrung

Michael Pirrung, Ph.D., was trained as a synthetic organic chemist at UT-Austin, UC-Berkeley, and Columbia University with eminent synthetic chemists Clayton Heathcock and Gilbert Stork. His independent career began in the 1980s at Stanford University and the biotech start-up company Affymax. In 1990, he joined Duke University where he founded and directed the Program in Biological Chemistry. In 2004, he joined the UC-Riverside Chemistry department as UC Presidential Chair, and in 2012 became Distinguished Professor. He has been a visiting professor at UC-Berkeley, Baylor College of Medicine, Oxford, UC-San Diego, UC-Irvine, and Caltech. He has trained over 100 graduate students and postdoctoral fellows. He has held Hertz, Sloan, and Guggenheim fellowships and a NSF Presidential Young Investigator Award. He has over 170 peer-reviewed publications, more than 40 US and international patents, and has authored six books. The scope of his research has been broad, including natural product total synthesis, photochemical methods development, mechanistic enzymology, rhodium carbenoid chemistry, microarrays, combinatorial chemistry, and medicinal chemistry. His current work emphasizes peptide chemistry. His microarray work has been particularly recognized, with the 1991 AAAS-Newcomb Cleveland Prize, the 1993 Intellectual Property Owners Distinguished Inventor Award, the 2004 Chemical Pioneer Award of the American Institute of Chemists, and the 2006 European Inventor of the Year (for small and medium-sized enterprises). His editorial board service includes Cell Chemical Biology and Journal of Combinatorial Chemistry. He has worked extensively with development-stage and Fortune 500 companies as a consultant or scientific advisory board member. He also has an active practice as an expert witness for litigation in nucleic acid diagnostics and generic drugs.

Affiliations and Expertise

University of California, Riverside, USA