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Molecular Design and Modeling: Concepts and Applications, Part B: Antibodies and Antigens, Nucleic Acids, Polysaccharides, and Drugs - 1st Edition - ISBN: 9780121821043, 9780080883182

Molecular Design and Modeling: Concepts and Applications, Part B: Antibodies and Antigens, Nucleic Acids, Polysaccharides, and Drugs, Volume 203

1st Edition

Editors in Chief: John Abelson Melvin Simon
Serial Volume Editor: John Langone
eBook ISBN: 9780080883182
Imprint: Academic Press
Published Date: 1st November 1991
Page Count: 764


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Table of Contents

Antibodies and Antigens: Antibody Combining Site: E.A. Padlan and E.A. Kabat, Modeling of Antibody Combining Sites. M.B. Bolger and M.A. Sherman, Computer Modeling of the Combining Site Structure of Anti-hapten Monoclonal Antibodies. J.S. Huston, M. Mudgett-Hunter, M.-S. Tai, J. McCartney, F. Warren, E. Haber, and H. Oppermann, Protein Engineering of Single-Chain Fv Analogs and Fusion Proteins. S. Johnson and R.E. Bird, Construction of Single-Chain Fv Derivatives of Monoclonal Antibodies and Their Production in Escherichia coli. D. Gadussow and G. Seemann, Humanization of Monoclonal Antibodies. Antibody-Antigen Interactions: A.C.R. Martin, J.C. ~Cheetham, and A. Rees, Molecular Modeling of Antibody Combining Sites. I.A. Wilson, J.M. Rini, D.H. Fremont, G.G. Fieser, and E.A Stura, X-Ray Crystallographic Analysis of Free and Antigen-Complexed Fab Fragments to Investigate Structural Basis of Immune Recognition. J.L. Pellequer, E. Westhof, and M.H.V. Van Regenmortel, Predicting Location of Continuous Epitopes in Proteins from Their Primary Structures. J.C. Cheetham, C. Redfield, R.E. Griest, C.M. Dobson, and A.R. Rees, Use of Two-Dimensional 1H Nuclear Magnetic Resonance to Study High-Affinity Antibody-Peptide Interactions. J. Anglister and F. Naider, Nuclear Magnetic Resonance for Studying Peptide-Antibody Complexes by Transferred Nuclear Overhauser Effect Difference Spectroscopy. P. Tsang, M. Rance, and P.E. Wright, ~Isotope-Edited Nuclear Magnetic Resonance Studies of Fab-Peptide Complexes. J.E. Jentoft, Reductive Methylation and Carbon-13 Nuclear Magnetic Resonance in Structure-Function Studies of the Fc Fragment and Its Subfragments. N. Boisset and J.N. Lamy, Immunoelectron Microscopy and Image Processing for Epitope Mapping. W.-J. Syu and L. Kahan, Characterization of Antigenic Structures by Mapping on Resin-Bound Epitope Analogs. B.J. Walsh and M.E. Howden, Epitope Mapping of Allergens for Rapid Localization of Continuous Allergenic Determinants. M. Takahashi, S.A. Fuller, and S. Winston, Design and Production of Bispecific Monoclonal Antibodies by Hybrid Hybridomas for Use in ~Immunoassay. Catalytic Antibodies and Vaccines: K.M. Shokat and P.G. Schultz, Catalytic Antibodies. D. Hilvert and K.W. Hill, Antibody Catalysis of Concerted, Carbon-Carbon Bond-Forming Reactions. F. Sinigaglia, P. Romagnoli, M. Guttinger, B. Takacs, and J.R.L. Pink, Selection of T Cell Epitopes and Vaccine Engineering. D.J. Evans and J.W. Almond, Design, Construction, and Characterization of Poliovirus Antigen Chimeras. Nucleic Acids and Polysaccharides: W.K. Olson and P. Zhang, Computer Simulation of DNA Supercoiling. S. Neidle and T.C. Jenkins, Molecular Modeling to Study DNA Intercalation by Antitumor Drugs. E.L. Loechler, Molecular Modeling in Mutagenesis and Carcinogenesis. J. Peltonen, S. Jaakkola, and J. Uitto, In Situ Hybridization and Immunodetection Techniques for SimultaneousLocalization of Messenger RNAs and Protein Epitopes in Tissue Sections and Cultured Cells. P. Schimmel and J.J. Burbaum, Transfer RNA with Double Identity for in Vitro Kinetic Modeling of Transfer RNA Identity in Vivo. N.R. Pace and D.S. Waugh, Design of Simplified Ribonuclease P RNA by Phylogenetic Comparison. S. P~aaerez, Molecular Modeling and Electron Diffraction of Polysaccharides. A.D. Cardin, D.A. Demeter, H.J.R. Weintraub, and R.L. Jackson, Molecular Design and Modeling of Protein-Heparin Interactions. Drugs: Y.C. Martin, Computer-Assisted Rational Drug Design. D.J. Livingstone, Pattern Recognition in Rational Drug Design. P.-A. Carrupt, N. El Tayar, A. Karlen, and B. Testa, Molecular Electrostatic Potentials for ~Characterizing Drug-Biosystem Interactions. T.M. Gund and C.E. Spivak, Pharmacophore for Nicotinic Agonists. Cross-Index to Prior Volumes: Related Chapters Published in Previous Volumes of Methods in Enzymology. Each chapter includes references. Author Index. Subject Index.


Computer-based design and modeling, computational approaches, and instrumental methods for elucidating molecular mechanisms of protein folding and ligand-acceptor interactions are included in Volumes 202 and 203, as are genetic and chemical methods for the production of functional molecules including antibodies and antigens, enzymes, receptors, nucleic acids and polysaccharides, and drugs.


Biochemists, cell biologists, molecular biologists, developmental biologists, geneticists, and biophysicists.


No. of pages:
© Academic Press 1991
1st November 1991
Academic Press
eBook ISBN:


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About the Editors in Chief

John Abelson

Affiliations and Expertise

California Institute of Technology, Division of Biology, Pasadena, U.S.A.

Melvin Simon

Affiliations and Expertise

The Salk Institute, La Jolla, CA, USA

About the Serial Volume Editor

John Langone

Affiliations and Expertise

Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Maryland, U.S.A.