Molecular Cell Pathology - 1st Edition - ISBN: 9780123649324, 9781483218410

Molecular Cell Pathology

1st Edition

Editors: G. W. Richter Kim Solez
eBook ISBN: 9781483218410
Imprint: Academic Press
Published Date: 28th May 1991
Page Count: 296
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International Review of Experimental Pathology, Volume 32: Molecular Cell Pathology discusses the applications and practical value of in situ hybridization; the interactions between endothelial cells and the cells of the immune system; and the molecular biology of cytokine effects on vascular endothelial cells. The text also describes the interphase nucleolar organizer regions in cancer cells; the disease associations, molecular biology, and pathophysiology of antineutrophil cytoplasmic autoantibodies; and the mechanisms and roles of apoptosis in pathology. The molecular events in measles virus infection of the central nervous system are also considered. Pathologists, microbiologists, and immunologists will find the book useful.

Table of Contents


Applications of in Situ Hybridization

I. Introduction

II. Methodology

III. Applications

IV. Practical Value for Histopathology


Interactions between Endothelial Cells and the Cells of the Immune System

I. Introduction

II. Interactions between Endothelial Cells and Immune System Cells in the Control of Coagulation

III. Lymphocyte/Endothelial Cell Interactions in Lymphocyte Recirculation

IV. Interactions between Endothelial Cells and Immune System Cells in the Regulation of Mononuclear Cell Migration into Inflammatory Lesions

V. The Role of Cytokines in the Activation of Endothelial Cells at Sites of Inflammation

VI. The Effects of Cytokines on Endothelial Cell Expression of MHC Antigens and Their Possible Role in Endothelial Cell Antigen Presentation

VII. Endothelial Cell Proliferation and Angiogenesis

VIII. Effects of Endothelial Cell Products on the Function of Immune System Cells

IX. Conclusions


Molecular Biology of Cytokine Effects on Vascular Endothelial Cells

I. Introduction

II. Molecular Basis of Cytokine Responsiveness of Vascular Endothelial Cells

III. Regulation and Induction of Endothelial Gene Expression by Cytokines

IV. Endothelial Gene Expression in in Vivo and in Situ Hybridization

V. Future Directions of Research


Interphase Nucleolar Organizer Regions in Cancer Cells

I. Introduction

II. Silver Staining Techniques for the Visualization of NORs

III. General Factors Influencing the Specificity of the Silver Stain for NORs

IV. Molecular Components Responsible for Silver Staining

V. NORs Not Stained by the Ag-NOR Techniques

VI. Localization of NORs in Interphase Nucleoli

VII. Structure and Function of Interphase NORs

VIII. Nucleolar Morphology

IX. Interphase NOR Distribution

X. Distribution of Silver-Stained Interphase NORs in Neoplastic Cells

XI. Is the High Number of Interphase NORs a Peculiar Feature of Cancer Cells

XII. Relationship between Interphase NOR Distribution and Neoplastic State of the Cell

XIII. Structural Changes of Ribosomal Genes in Cells Stimulated to Proliferate


Antineutrophil Cytoplasmic Autoantibodies: Disease

I. Introduction

II. Clinical and Pathologic Spectrum of ANCA-Associated Diseases

III. Elucidation of ANCA Antigen Specificity

IV. Pathogenetic Potential of ANCAs

V. Conclusion


Apoptosis: Mechanisms and Roles in Pathology

I. Introduction

II. Morphology

III. Mechanisms

IV. Roles in Pathology

V. Conclusions


Molecular Events in Measles Virus Infection of the Central Nervous System

I. Introduction

II. Clinical and Epidemiological Features

III. Pathology of Measles-Infected Brain Tissue

IV. Properties of Measles Virus

V. Viral Protein Expression

VI. Viral Gene Expression

VII. Role of Antibodies in Viral Persistence

VIII. CNS Damage by Measles Virus

IX. Concluding Remarks




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© Academic Press 1991
Academic Press
eBook ISBN:

About the Editor

G. W. Richter

Kim Solez

Affiliations and Expertise

Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton

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