Molecular Biology

Molecular Biology

3rd Edition - November 2, 2018

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  • Authors: David Clark, Nanette Pazdernik, Michelle McGehee
  • Hardcover ISBN: 9780128132883
  • eBook ISBN: 9780128132890

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Molecular Biology, Third Edition, provides a thoroughly revised, invaluable resource for college and university students in the life sciences, medicine and related fields. This esteemed text continues to meet the needs of students and professors by offering new chapters on RNA, genome defense, and epigenetics, along with expanded coverage of RNAi, CRISPR, and more ensuring topical content for a new class of students. This volume effectively introduces basic concepts that are followed by more specific applications as the text evolves.Moreover, as part of the Academic Cell line of textbooks, this book contains research passages that shine a spotlight on current experimental work reported in Cell Press articles. These articles form the basis of case studies found in the associated online study guide that is designed to tie current topics to the scientific community.

Key Features

  • Winner of a 2020 Textbook Excellence Award (College) (Texty) from the Textbook and Academic Authors Association
  • Contains new chapters on non-coding RNA, genome defense, epigenetics and epigenomics
  • Features new and expanded coverage of RNAi, CRISPR, genome editing, giant viruses and proteomics
  • Provides an ancillary package with updated PowerPoint slide images


Undergraduate students taking a course in Molecular Biology; upper-level students studying Cell Biology, Microbiology, Genetics, Biology, Pharmacology, Biotechnology, Biochemistry, and agriculture

Table of Contents

  • Unit 1: Basic Chemical and Biological Principles
    1. Cells and Organisms
    2. Basic Genetics
    3. DNA, RNA, and Protein
    4. Genes, Genomes, and DNA
    5. Manipulation of Nucleic Acids

    Unit 2: The Genome
    6. The Polymerase Chain Reaction
    7. Cloning Genes for Analysis
    8. DNA Sequencing
    9. Genomics and Systems Biology
    New Chapter to cover metagenomics, symbiosis, epigenomics etc

    Unit 3: The Central Dogma of Molecular Biology
    10. Cell Division and DNA Replication
    11. Transcription of Genes
    12. Processing of RNA (moved to Unit 4)
    13. Protein Synthesis
    14. Protein Structure and Function
    15. Proteomics: Global Analysis of Proteins

    Unit 4: Regulating Gene Expression
    16. Regulation of Transcription in Prokaryotes
    17. Regulation of Transcription in Eukaryotes
    12. Processing of RNA (moved from Unit 3)
    18. Regulation at the RNA Level
    New Chapter on Genome defense (RNAi and CRISPR). Would include their use in genetic analysis and genome editing
    19. Analysis of Gene Expression (Transcriptome)

    Unit 5: Subcellular Life Forms
    20. Plasmids
    21. Viruses
    22. Mobile DNA

    Unit 6: Changing the DNA Blueprint
    23. Mutations and Repair
    24. Recombination
    25. Bacterial Genetics
    26. Molecular Evolution

Product details

  • No. of pages: 1006
  • Language: English
  • Copyright: © Academic Cell 2018
  • Published: November 2, 2018
  • Imprint: Academic Cell
  • Hardcover ISBN: 9780128132883
  • eBook ISBN: 9780128132890

About the Authors

David Clark

David Clark
David P. Clark did his graduate work on bacterial antibiotic resistance to earn his Ph.D. from Bristol University, in the West of England. During this time, he visited the British Government's biological warfare facility at Porton Down and was privileged to walk inside the (disused) Black Death fermenter. He later crossed the Atlantic to work as a postdoctoral researcher at Yale University and then the University of Illinois. David Clark recently retired from teaching Molecular Biology and Bacterial Physiology at Southern Illinois University which he joined in 1981. His research into the Regulation of Alcohol Fermentation in E. coli was funded by the U.S. Department of Energy, from 1982 till 2007. From 1984-1991 he was also involved in a project to use genetically altered bacteria to remove contaminating sulfur from coal, jointly funded by the US Department of Energy and the Illinois Coal Development Board. In 1991 he received a Royal Society Guest Research Fellowship to work at Sheffield University, England while on sabbatical leave. He has supervised 11 master’s and 7 PhD students and published approximately 70 articles in scientific journals. He has written or co-authored several textbooks, starting with Molecular Biology Made Simple and Fun (with Lonnie Russell; (Cache River Press, First edition, 1997) which is now in its fourth edition. Other books are Molecular Biology and Biotechnology (both published by Elsevier) He recently wrote a popular science book, Germs, Genes, & Civilization: How Epidemics Shaped Who We Are Today (2010, Financial Times Press/Pearson). David is unmarried, but his life is supervised by two cats, Little George and Mr Ralph.

Affiliations and Expertise

Southern Illinois University, Carbondale, Illinois, USA

Nanette Pazdernik

Nanette Pazdernik
Nanette J. Pazdernik, Ph.D. is a co-author of Biotechnology, 2nd edition and Molecular Biology, 2nd edition, with Dr. David Clark. The second edition of Molecular Biology won a Texty award from the Textbook and Academic Authors Association in 2013. She has also authored an on-line study guide to accompany the update edition of Molecular Biology. She has taught courses in General Biology, Genetics, as well as Anatomy and Physiology at Southwestern Illinois College, McKendree University, and Harris-Stowe University. She received her BA in Biology from Lawrence University in Appleton, Wisconsin, in 1990 and her PhD in Molecular, Cellular, Developmental Biology and Genetics from the University of Minnesota in 1996. Her doctoral thesis studied how alterations in the structure of lactose permease affect its ability to transport sugar across the membrane of E. coli. Following her degrees, she investigated the IL-1 and TNF signal transduction pathways that control apoptosis and immunity at Indiana University School of Medicine. She has most recently studied the various molecules that maintain the stem cell fate in C. elegans at Washington University School of Medicine in St. Louis, MO. She is married and the mother of three children, ages 15, 12, and 8, which always make her realize the role biology plays in personality and development!

Affiliations and Expertise

Washington University School of Medicine, St. Louis, Missouri, USA

Michelle McGehee

Michelle R. McGehee earned a BA in Microbiology in 2000 and a PhD in Molecular Biology, Microbiology, and Biochemistry in 2005, both from Southern Illinois University in Carbondale, IL. Her graduate research focused on the genetic and biochemical regulation of lactate fermentation in Escherichia coli and was supervised by Dr. David P. Clark. After graduation, she accepted a postdoctoral research associate position at Texas A&M Health Science Center in College Station, TX, where she investigated the molecular pathogenesis of Borrelia burgdorferi. Prior to Molecular Biology, 3e, she contributed to the ancillary materials and online study guide for Molecular Biology’s first two editions, as well as to the ancillaries for the companion book Biotechnology, also published by Elsevier. She is currently a biology professor at a college in Texas, where she teaches courses in anatomy & physiology and both majors and non-majors microbiology. She also challenges high school students in science competitions as the state biology contest director for the University Interscholastic League through The University of Texas at Austin. In her spare time, she enjoys hiking and camping with her loyal partner, a border collie named Ria.

Affiliations and Expertise

Biology Professor, TX, USA

Ratings and Reviews

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  • Ricardo P. Tue Dec 07 2021

    Highly recommended book!

    I am really enjoying reading this book and think that is a very good option for everyone interested in molecular biology due that it explains in simple terms some complex concepts.

  • Vincenzo Tue Aug 10 2021

    Very nice book

    One of the most recent and updated molecular biology book

  • MilindBorde Thu Aug 08 2019

    Molecular Biology

    This is an excellent introduction to molecular biology. It covers the entire field in depth. Explainations and diagrams are clear. The book is profusely illustrated and is easy to follow for any person with a basic knowledge of biology, organic chemistry and biochemistry.

  • JenkinPe Sun Jan 27 2019

    Comprehensive cover of the subject

    As a first book to a premedical students like me, the book provides a good coverage of the fundamental concepts and practice in Molecular Biology. I benefit much from reading through the book.