Molecular Biology - 1st Edition

Molecular Biology

1st Edition

Authors: David Clark
Imprint: Academic Cell
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Molecular Biology: Academic Cell Update provides an introduction to the fundamental concepts of molecular biology and its applications. It deliberately covers a broad range of topics to show that molecular biology is applicable to human medicine and health, as well as veterinary medicine, evolution, agriculture, and other areas. The present Update includes journal specific images and test bank. It also offers vocabulary flashcards.

The book begins by defining some basic concepts in genetics such as biochemical pathways, phenotypes and genotypes, chromosomes, and alleles. It explains the characteristics of cells and organisms, DNA, RNA, and proteins. It also describes genetic processes such as transcription, recombination and repair, regulation, and mutations. The chapters on viruses and bacteria discuss their life cycle, diversity, reproduction, and gene transfer. Later chapters cover topics such as molecular evolution; the isolation, purification, detection, and hybridization of DNA; basic molecular cloning techniques; proteomics; and processes such as the polymerase chain reaction, DNA sequencing, and gene expression screening.

Key Features

  • Up to date description of genetic engineering, genomics, and related areas
  • Basic concepts followed by more detailed, specific applications
  • Hundreds of color illustrations enhance key topics and concepts
  • Covers medical, agricultural, and social aspects of molecular biology
  • Organized pedagogy includes running glossaries and keynotes (mini-summaries) to hasten comprehension


Undergraduate students taking a course in Molecular Biology; upper-level students studying Cell Biology, Microbiology, Genetics, Biology, Pharmacology, Biotechnology, Biochemistry and Agriculture

Table of Contents

Chapter 1 Basic Genetics Chapter 2 Cells and Organisms Chapter 3 DNA, RNA and Protein Chapter 4 Genes, Genomes and DNA Chapter 5 Cell Division and DNA Replication Chapter 6 Transcription of Genes Chapter 7 Protein Structure and Function Chapter 8 Protein Synthesis Chapter 9 Regulation of Transcription in Prokaryotes Chapter 10 Regulation of Transcription in Eukaryotes Chapter 11 Regulation at the RNA Level Chapter 12 Processing of RNA Chapter 13 Mutations Chapter 14 Recombination and Repair Chapter 15 Mobile DNA Chapter 16 Plasmids Chapter 17 Viruses Chapter 18 Bacterial Genetics Chapter 19 Diversity of Lower Eukaryotes Chapter 20 Molecular Evolution Chapter 21 Nucleic Acids: Isolation, Purification, Detection, and Hybridization Chapter 22 Recombinant DNA Technology Chapter 23 The Polymerase Chain Reaction Chapter 24 Genomics and DNA Sequencing Chapter 25 Analysis of Gene Expression Chapter 26 Proteomics: The Global Analysis of Proteins Glossary Index


Academic Cell
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About the Author

David Clark

David P. Clark did his graduate work on bacterial antibiotic resistance to earn his Ph.D. from Bristol University, in the West of England. During this time, he visited the British Government's biological warfare facility at Porton Down and was privileged to walk inside the (disused) Black Death fermenter. He later crossed the Atlantic to work as a postdoctoral researcher at Yale University and then the University of Illinois. David Clark recently retired from teaching Molecular Biology and Bacterial Physiology at Southern Illinois University which he joined in 1981. His research into the Regulation of Alcohol Fermentation in E. coli was funded by the U.S. Department of Energy, from 1982 till 2007. From 1984-1991 he was also involved in a project to use genetically altered bacteria to remove contaminating sulfur from coal, jointly funded by the US Department of Energy and the Illinois Coal Development Board. In 1991 he received a Royal Society Guest Research Fellowship to work at Sheffield University, England while on sabbatical leave. He has supervised 11 master’s and 7 PhD students and published approximately 70 articles in scientific journals. He has written or co-authored several textbooks, starting with Molecular Biology Made Simple and Fun (with Lonnie Russell; (Cache River Press, First edition, 1997) which is now in its fourth edition. Other books are Molecular Biology and Biotechnology (both published by Elsevier) He recently wrote a popular science book, Germs, Genes, & Civilization: How Epidemics Shaped Who We Are Today (2010, Financial Times Press/Pearson). David is unmarried, but his life is supervised by two cats, Little George and Mr Ralph.

Affiliations and Expertise

Southern Illinois University, Carbondale, Illinois, USA


"This is an excellent book. It is very lucidly written. Clark covers a suitable set of topics, and treats each topic very thoroughly...He is very up-to-date in his coverage of the material." - John G. Burr, University of Texas at Dallas "This textbook is very comprehensive, covering nearly all aspects of molecular biology and genetics. The textbook excels in defining key terms in a clear and understable way...The sprinkling of little side stories...keeps the reader interested, and kept me glued throughout the text." - B. Franklin Pugh, Penn State University "The author did a very good job covering this vast subject and offered many insightful perspectives." - John F. Cannon, University of Missouri