The importance of protein folding has been recognized for many years. It is the underlying etiology in a large number of human diseases and it appears to be a novel method for cellular regulation of the expression of newly translated proteins. These volumes (Parts A & B) address this important topic. As a volume in Progress in Nucleic Acid Research and Molecular Biology, this book provides the latest information on the expanding research being conducted on protein folding.

Key Features

*Follow the new editor-in-chief, P. Michael Conn, as he introduces this first thematic volume in the series – an in-depth aid to researchers who are looking for the best techniques and tools for understanding the complexities of protein folding *Understand the advantages of protein folding over other therapeutic approaches and see how protein folding plays a critical role in the development of diseases such as Alzheimer’s and diabetes *Decipher the rules of protein folding through compelling and timely reviews combined with chapters written by international authors in engineering, biochemistry, physics and computer science


Researchers in molecular biology, biochemistry, cell biology, and genetics

Table of Contents

1. Stability and design of alpha-helical peptides - Andrew Doig 2. Under-wrapped protein folds in disease and epigenetic change - Ariel Fernandez 3. Self-organizing dynamics in protein folding - Bernard S. Gerstman 4. Diffusive models for protein folding - Stephen J Hagen 5. Toward reliable simulations of protein folding, misfolding and aggregation - Ulrich HE Hansmann 6. Single-molecule fluorescence studies of protein folding - Gilad Haran 7. Algorithms for protein folding - Sorin Istrail 8. Use of protein engineering techniques to elucidate protein folding pathways - Sophie Jackson 9. The kinetic stabilities of wild-type and disease-associated mutants of aromatic amino acid hydroxylases. Effect of natural chaperone ligand - Aurora Martinez 10. Chaperone-assisted protein folding in the endoplasmic reticulum - Maurizio Molinari 11. Protein folding over marginal barriers: ensembles, dynamics and stochastics - Victor Munoz


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© 2008
Academic Press
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