Molecular Biology of Neurodegenerative Diseases: Visions for the Future - 1st Edition - ISBN: 9780128178744, 9780128178751

Molecular Biology of Neurodegenerative Diseases: Visions for the Future, Volume 168

1st Edition

Serial Volume Editors: David Teplow
Hardcover ISBN: 9780128178744
eBook ISBN: 9780128178751
Imprint: Academic Press
Published Date: 6th November 2019
Page Count: 408
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Table of Contents

Section I: TARGETTING AD

1. Fluid biomarker-based molecular phenotyping of Alzheimer's disease patients in research and clinical settings

Kaj Blennow and Henrik Zetterberg

2. Tracking down a missing trigger for Alzheimer's disease by mass spectrometric imaging based on brain network analysis

Minako Hoshi

3. Using mirror-image peptides to enhance robustness and reproducibility in studying the amyloid β-protein

Ariel J. Kuhn and Jevgenij A. Raskatov

Section II: ETIOLOGY OF AD

4. In search of pathogenic amyloid β-peptide in familial Alzheimer's disease

Michael S. Wolfe

5. Biology of splicing in Alzheimer's disease research

Kenichi Nagata, Takashi Saito, Takaomi C. Saido and Takashi Morihara

6. Acquired cerebral amyloid angiopathy: An emerging concept

Masahito Yamada, Tsuyoshi Hamaguchi and Kenji Sakai

Section III: NEUROIMMUNOLOGY OF AD

7. Blood-brain barrier and innate immunity in the pathogenesis of Alzheimer's disease

Goran Šimić, Ena Španić, Lea Langer Horvat and Patrick R. Hof

8. Gut microbiota mediated allostasis prevents stress-induced neuroinflammatory risk factors of Alzheimer's disease

Susan Westfall, Umar Iqbal, Maria Sebastian and Giulio Maria Pasinetti

9. Neuroimmune interactions in Alzheimer’s disease—New frontier with old challenges?

Stefan Prokop, Virginia M.Y. Lee and John Q. Trojanowski

Section IV: AD THERAPY

10. Alzheimer's therapy development: A few points to consider

Einar M. Sigurdsson

11. The next steps in curing Alzheimer's disease

Fred W. van Leeuwen

12. Future horizons in Alzheimer's disease research

Thomas Wisniewski and Eleanor Drummond

13. Why delay in effective treatment for Alzheimer's disease and related conditions

Khalid Iqbal, Fei Liu, ChengXin Gong, Chunling Dai and Wen Hu

14. Restoring synaptic function through multimodal therapeutics

Raul Loera-Valencia, Muhammad-Al-Mustafa Ismail, Per Nilsson and Bengt Winblad

15. Disease-modifying therapy for proteinopathies: Can the exception become the rule?

Gal Bitan

16. Combination therapy for Alzheimer’s disease and related dementias

Martin M. Bednar

Section V: ALPHA-SYNUCLEINOPATHIES

17. Can infections trigger alpha-synucleinopathies?

Christopher T. Tulisiak, Gabriela Mercado, Wouter Peelaerts, Lena Brundin and Patrik Brundin

18. Prion-like propagation of α-synuclein in neurodegenerative diseases

Airi Tarutani and Masato Hasegawa

Section VI: MODEL SYSTEMS

19. Yeast models of neurodegenerative diseases

Mick F. Tuite


Description

Molecular Biology of Neurodegenerative Diseases: Visions for the Future, Volume 168 in the Progress in Molecular Biology and Translational Science series, provides the most topical, informative and exciting monographs available on a wide variety of research topics. The series includes in-depth knowledge on the molecular biological aspects of organismal physiology, with this release including chapters on Alzheimer's disease, Prion-like propagation of alpha-synuclein, What - if anything - can we learn about neurodegenerative diseases from yeast?, Mitochondrial rejuvenation and replacement as a novel strategy for treatment of age-related neurodegenerative diseases, Propagation and removal of cerebral amyloid angiopathy, and much more.

Key Features

  • Includes comprehensive coverage of molecular biology
  • Presents ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided
  • Contains contributions from renowned experts in the field

Readership

Scientists working actively in a field, including those at levels ranging from graduate student to senior investigator. New investigators to a field who wish to familiarize themselves with the latest work


Details

No. of pages:
408
Language:
English
Copyright:
© Academic Press 2019
Published:
6th November 2019
Imprint:
Academic Press
Hardcover ISBN:
9780128178744
eBook ISBN:
9780128178751

Ratings and Reviews


About the Serial Volume Editors

David Teplow

David Teplow Serial Volume Editor

Professor Teplow is a member of the Department of Neurology, David Geffen School of Medicine at UCLA; Director, UCLA Biopolymer Laboratory; and a member of the faculties of the Molecular Biology Institute, Brain Research Institute, Chemistry-Biology Interface Training Program, and various neuroscience graduate programs. Professor Teplow received degrees in Biochemistry, and in Bacteriology & Immunology, from UC Berkeley; a Ph.D. from the University of Washington, Seattle; and postdoctoral training at the California Institute of Technology, Pasadena, CA. From 1991-2005, Professor Teplow was a member of the faculty of the Department of Neurology, Harvard Medical School, Boston. Professor Teplow has published >200 peer-reviewed articles, including ~150 original articles and ~50 reviews, book chapters, and commentaries. Professor Teplow was a founding editor of the Journal of Molecular Neuroscience and Current Chemical Biology. He currently is Associate Editor-in-Chief of the American Journal of Neurodegenerative Disease. Professor Teplow is a member of numerous national and international scientific advisory and editorial boards.

Affiliations and Expertise

David Geffen School of Medicine, UCLA, Los Angeles, CA, USA