Molecular Biology of Eye Disease

Molecular Biology of Eye Disease

1st Edition - August 1, 2015

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  • Editors: J Fielding Hejtmancik, John Nickerson
  • eBook ISBN: 9780128012673
  • Hardcover ISBN: 9780128010594

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This volume of Progress in Molecular Biology and Translational Science focuses on the molecular biology of eye disease.

Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field


Students, researchers, microbiologists, molecular biologists

Table of Contents

  • 1. Overview of the Visual System
    J. Fielding Hejtmancik and John M. Nickerson

    2. Cornea

    2.a. Overview of the Cornea: Structure, Function, and Development
    Allen O. Eghrari, S. Amer Riazuddin and John D. Gottsch

    2.b.  Stem Cells in the Cornea
    Andrew J. Hertsenberg and James L. Funderburgh

    2.c.  Corneal Development: Different Cells from a Common Progenitor
    Peter Y. Lwigale

    2.d.  Corneal Epithelial Wound Healing 
    Chia-Yang Liu and Winston Whey-Yang Kao

    2.e.i. Corneal Dystrophies: Overview and summary
    Daniel Schorderet

    2.e.ii. Fuchs Corneal Dystrophy
    Allen O. Eghrari, S. Amer Riazuddin and John D. Gottsch

    2.e.iii. Molecular Pathogensis of Corneal Dystrophies: Schnyder Dystrophy and Granular Corneal Dystrophy 2
     Eung Kweon Kim, Hun Lee and Seung-il Choi

    3. Lens

    3.a.  Overview of the Lens
    J. Fielding Hejtmancik and Alan Shiels

    3.b.  Lens Development and Crystallin Gene Expression
    Ales Cvekl, Rebecca McGreal, and Wei Liu

    3.c.  Lens Biology and Biochemistry
    J. Fielding Hejtmancik, S. Amer Riazuddin, Rebecca McGreal, Wei Liu, Ales Cvekl, and Alan Shiels

    3.d.  Molecular Genetics of Cataract
    Alan Shiels and J. Fielding Hejtmancik

    4. Refraction

    4.a. RPE and Choroid Mechanisms Underlying Ocular Growth and Myopia
    Yan Zhang and Christine Wildsoet

    4.b.  Scleral Mechanisms Underlying Ocular Growth and Myopia
    Ravi Metlapally and Christine F. Wildsoet

     4.c. Molecular and Biochemical Aspects of the Retina on Refraction
    Ranjay Chakraborty and Machelle T. Pardue

    4.d.  Genetics of Refraction and Myopia
    Qingjiong Zhang

    5. Ocular Immunity

    5.a.  Molecular Genetic Advances in Uveitis
    Shengping Hou, Aize Kijlstra and Peizeng Yang

    6. Aqueous Flow and Intraocular Pressure

    6.a.  Intraocular Pressure and the Mechanisms Involved in Resistance the Aqueous Humor Flow in the Trabecular Meshwork Outflow Pathways
    Ernst R. Tamm, Barbara M. Braunger and Rudolf Fuchshofer

    6.b. Glaucoma Genes and Mechanisms
    Janey L. Wiggs

    6.c. Neuroinflammation in Glaucoma and Optic Nerve Damage
    Caitlin E. Mac Nair and Robert W. Nickells

    6.d. What Animal Models Can Tell Us about Glaucoma
    Felix L. Struebing and Eldon E. Geisert

    7. Retina

    7.a. Introduction to the Retina
    Hans E. Grossniklaus, Eldon E. Geisert and John M. Nickerson

    7.b.  Development of the Vertebrate Eye and Retina
    Deborah L. Stenkamp

    7.c.  Insights into the Molecular Properties of ABCA4 and its Role in the Visual Cycle and Stargardt Disease
    Robert S. Molday

    7.d. A History of the Classical Visual Cycle
    Charles B. Wright, T. Michael Redmond and John M Nickerson

    7.e.  A2E and Lipofuscin
    Rosalie K. Crouch, Yiannis Koutalos, Masahiro Kono, Kevin Schey and Zsolt Ablonczy

    7.f. Cone Health and Retinoids
    Masahiro Kono

    7.g.  Retinoid Processing in Induced Pluripotent Stem-Cell-Derived Retinal Pigment Epithelium Cultures
    Mark A. Fields, Hannah E. Bowrey, Jie Gong, Zsolt Ablonczy and Lucian V. Del Priore

    7.h.  Potential Role of Exercise in Retinal Health
    Machelle T. Pardue, Micah A. Chrenek, Robin H. Schmidt, John M. Nickerson and Jeffrey H. Boatright

    7.i. The Biology of Retinoblastoma
    Pia R. Mendoza and Hans E. Grossniklaus

    e-chapter: The 11-cis Retinal Origins of Lipofuscin in the Retina
    Leopold Adler IV, Nicholas P. Boyer, Chunhe Chen, Zsolt Ablonczy, Rosalie K. Crouch, Yiannis Koutalos



Product details

  • No. of pages: 548
  • Language: English
  • Copyright: © Academic Press 2015
  • Published: August 1, 2015
  • Imprint: Academic Press
  • eBook ISBN: 9780128012673
  • Hardcover ISBN: 9780128010594

About the Serial Volume Editors

J Fielding Hejtmancik

J Fielding Hejtmancik

Affiliations and Expertise

Ophthalmic Genetics and Visual Function Branch, Ophthalmic Molecular Genetics Section, Rockville, USA

John Nickerson

Affiliations and Expertise

Department of Ophthalmology, Emory University, Atlanta, USA

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