Molecular Basis of Thyroid Hormone Action - 1st Edition - ISBN: 9780125275606, 9780323147453

Molecular Basis of Thyroid Hormone Action

1st Edition

Editors: Jack Oppenheimer
eBook ISBN: 9780323147453
Imprint: Academic Press
Published Date: 28th January 1983
Page Count: 514
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Molecular Basis of Thyroid Hormone Action focuses on the actions of thyroid hormones in eukaryotic cells. This book discusses the profound effects of thyroid hormones on the growth, development, and metabolism of practically all tissues of higher organisms. Organized into 15 chapters, this volume starts with an overview of the kinetic interrelationships of hormone bound to specific receptors and hormone associated with other tissue and plasma pools in living animals. This book then discusses the thyroid hormone receptor, a chromatin-associated protein that appears to mediate the actions of the thyroid hormones in mammalian cells. Other chapters consider the localization of the receptors in chromatin. This book further discusses how thyroid hormones stimulate the accumulation of specific mRNA molecules in cell culture as well as in tissues in vivo. This book is intended for readers who are interested in cell and molecular biology. Endocrinologists will also find this book extremely useful.

Table of Contents



1 The Nuclear Receptor-Triiodothyronine Complex: Relationship to Thyroid Hormone Distribution, Metabolism, and Biological Action

I. Introduction

II. Distribution and Metabolism of the Thyroid Hormones

III. Kinetic Relationship of Nuclear T3 to Other T3 Pools

IV. The Initiating Role of the Nuclear Binding Site

V. Quantitative Relationship between Nuclear Occupancy and Response

VI. Lag Time of Thyroid Hormone Effects

VII. Concluding Remarks


2 Identification and Characterization of Thyroid Hormone Receptors and Action Using Cell Culture Techniques

I. Introduction

II. Biological Effects of Thyroid Hormone in Cell Culture

III. Identification and Characterization of Thyroid Hormone Receptors in Cultured Cells

IV. Modulation of Thyroid Hormone Nuclear Receptor Levels

V. Summary and Conclusions


3 Physicochemical Characterization of the Intranuclear Thyroid Hormone Receptor

I. Introduction

II. Intranuclear Localization of the Thyroid Hormone Receptor

III. DNA Binding Properties of the Receptor

IV. Physical Characteristics of the Solubilized Nuclear Receptors

V. Interaction of the Solubilized Nuclear Receptor with Thyroid Hormone

VI. Purification of the Nuclear Thyroid Hormone Receptor

VII. Summary


4 Thyroid Hormone Receptor Synthesis and Degradation and Interaction with Chromatin Components

I. Introduction

II. Quantitation of Receptor Half-Life and Estimation of Synthetic Rates Using Dense Amino Acid Labeling in GH1 Cells

III. Organization of the Receptor in Chromatin

IV. Summary and Conclusions


5 Nuclear-Cytoplasmic Interrelationships

I. Coordination of Thyroid Hormone-Induced Changes in Nuclear RNA Synthesis and Cytoplasmic Protein Synthesis

II. Nuclear and Cytoplasmic Thyroid Hormone Binding Proteins

III. Summary and Speculation


6 Effects of Thyroid Hormones on Cellular RNA Metabolism

I. Introduction

II. General RNA Effects

III. Specific Model Systems for Studying Thyroid Hormone Action

IV. Conclusions


7 Role of Thyroid Hormone in the Expression of αa2u-Globulin and Other Multihormonally Regulated Genes

I. Introduction

II. α2u-Globulin and Its Hepatic Synthesis

III. Purification of the Messenger RNA for α2u-Globulin and Cloning of the Double-Stranded cDNA

IV. Role of Androgenic and Estrogenic Steroids in the Hepatic Synthesis of α2u-Globulin

V. Multihormonal Regulation of α2u-Globulin

VI. Involvement of Thyroid Hormone in the Regulation of Several Other Multihormonally Regulated Genes

VII. Concluding Remarks


8 Regulation of Malic Enzyme in Hepatocytes in Culture: A Model System for Analyzing the Mechanism of Action of Thyroid Hormone

I. Introduction

II. Regulation of Malic Enzyme Activity in Culture

III. Turnover of Malic Enzyme in Hepatocytes in Culture

IV. Inhibitor and Kinetic Experiments

V. A Long-Lived Intermediate in Thyroid Hormone Action

VI. Effect of Thyroid Hormone on Other Lipogenic Enzymes

VII. Relationship between Regulation of Fatty Acid Biosynthesis and Regulation of Malic Enzyme Synthesis

VIII. Physiological and Teleological Significance


9 Thyroid Hormone-Carbohydrate Interaction

I. General Review

II. Regulation of Hepatic Lipogenic Enzymes Responsive to Both T3 and Carbohydrate

III. Concluding Remarks


10 Regulation of Thermogenesis by Thyroid Hormones

I. Cellular Metabolic Heat Production

II. Thyroid Thermogenesis and the Na+ Pump

III. Thyroid Involvement in Cold Acclimation

IV. The Genetically Obese (ob/ob) Mouse

V. Possible Role of Na+ Transport and Thyroid Hormone in the Evolutionary Transition from Poikilothermy to Homeothermy


11 The Effects of Thyroid Hormone on Adrenergic Receptors

I. Introduction

II. Effects of Thyroid Hormone on Adrenergic Receptors in the Heart

III. Effects of Thyroid Hormone on Adrenergic Receptors in Adipose Tissue

IV. Effects of Thyroid Hormone on Adrenergic Receptors in Other Tissues

V. Conclusions


12 Intrapituitary Mechanisms in the Control of TSH Secretion

I. Introduction

II. Physiological Studies on the Relationships among Serum Thyroid Hormone Concentrations, Thyroid Metabolic Status, and TSH Secretion

III. Studies of T3 and T4 in Pituitary Tissue

IV. Studies of Pituitary T4 to T3 Conversion in Vitro

V. Physiological and Clinical Implications of Pituitary T4 to T3 Conversion


13 Thyroid Hormone Regulation of Thyrotropin Production and Interaction with Thyrotropin Releasing Hormone in Thyrotropic Cells in Culture

I. Introduction

II. Thyrotropic Tumor (TtT) Cell Culture System

III. Characterization of Putative Nuclear Receptors for Thyroid Hormones in TtT Cells

IV. Effects of Thyroid Hormones on TRH Action in TtT Cells

V. Summary and Conclusions

14 Effect of Thyroid Hormone on Growth and Development

I. Introduction

II. Growth

III. Skeletal Growth and Maturation

IV. Central Nervous System

V. Lung

VI. Conclusion


15 Thyroid Hormone Action in Amphibian Metamorphosis

I. Introduction

II. General Pattern of Development of Anuran Amphibia

III. Thyroid Function and Circulating Hormone Levels in Anuran Amphibia

IV. Effects of Thyroid Hormone in Anuran Amphibia

V. Thyroid Hormone Receptors in Amphibian Tissues

VI. Relative Importance of T4 and T3 in Amphibia

VII. Concluding Comments




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© Academic Press 1983
Academic Press
eBook ISBN:

About the Editor

Jack Oppenheimer

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