Molecular Basis of Memory

Molecular Basis of Memory

1st Edition - January 30, 2014

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  • Editors: E. Chris Muly, Zafar Khan
  • Hardcover ISBN: 9780124201705
  • eBook ISBN: 9780124202009

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This special volume of Progress in Molecular Biology and Translational Science provides a current overview of how memory is processed in the brain. A broad range of topics are presented by leaders in the field, ranging from brain circuitry to synaptic plasticity to the molecular machinery that contributes to the brain's ability to maintain information across time. Memory systems in the prefrontal cortex, hippocampus and amygdala are considered as well. In addition, the volume covers recent contributions to our understanding of memory from in vivo imaging, optogenetic, electrophysiological, biochemical and molecular biological studies.

Key Features

  • Articles from world renowned experts in memory
  • Covering topics from signaling, epigenetic, RNA translation to  plasticity
  • Methodological approaches include molecular and cellular, behavioral, electrophysiological, optogenetic and functional imaging


Researchers, professors and graduate students in biochemistry, chemistry, molecular biology, biotechnology, and medicine.

Table of Contents

  • Contributors
    Chapter One: Memory Deficits in Aging and Neurological Diseases

    1 Introduction

    2 Memory Loss in Aging

    3 Memory Deficit in Alzheimer’s Disease

    4 Memory Impairment in Schizophrenia

    5 Concluding Remarks


    Chapter Two: The “Memory Kinases”

    1 Introduction

    2 Distribution of PKC Isoforms

    3 Structure of PKC Isoforms

    4 PKC Isoforms in Signal Transduction

    5 PKC Inhibitors

    6 PKC Activators

    7 Conclusions

    Chapter Three: CaMKII

    1 Memory and Synaptic Plasticity

    2 Molecular Mechanisms of LTP

    3 Synaptic Architecture

    4 Calcium/Calmodulin-Dependent Protein Kinase

    5 CaMKII Isoforms

    6 CaMKII Holoenzyme

    7 CaMKII Regulation

    8 CaMKII Targeting

    9 AMPAR-Mediated Potentiation

    10 CaMKII and LTD

    11 Concluding Remarks

    Chapter Four: The Transcription Factor Zif268/Egr1, Brain Plasticity, and Memory

    1 Introduction

    2 Zif268 and the Egr Family of Transcription Factors

    3 The Role of Zif268 in Synaptic Plasticity

    4 The Role of Zif268 in Learning and Memory

    5 Adult Neurogenesis: A New Role for Zif268

    6 Zif268 in Pathology

    7 Conclusions and Perspectives


    Chapter Five: Mechanisms of Translation Control Underlying Long-Lasting Synaptic Plasticity and the Consolidation of Long-Term Memory

    1 The Study and Characterization of Memory Systems

    2 Mechanisms of mTOR-Dependent Translational Control

    3 Translational Control Molecules Involved in Synaptic Plasticity and Memory

    4 Concluding Remarks

    Chapter Six: BDNF–TrkB Receptor Regulation of Distributed Adult Neural Plasticity, Memory Formation, and Psychiatric Disorders

    1 Brain-Derived Neurotrophic Factor

    2 BDNF, Long-Term Potentiation, and Synaptic Plasticity

    3 The Role of BDNF in Human Memory and Translational Studies

    4 Potential Therapeutic Uses of BDNF

    5 Conclusions

    Acknowledgments and Disclosures

    Chapter Seven: Mechanisms of Synaptic Plasticity and Recognition Memory in the Perirhinal Cortex

    1 Introduction

    2 Perirhinal Cortex and Recognition Memory

    3 Mechanisms of Synaptic Plasticity and Visual Recognition Memory

    4 Learning-Related Changes in Synaptic Transmission

    5 Conclusions

    Chapter Eight: Molecular Influences on Working Memory Circuits in Dorsolateral Prefrontal Cortex

    1 Working Memory, Our “Mental Sketch Pad”

    2 Microcircuits for Working Memory

    3 The Role of NMDARs

    4 The Arousal Systems Project to dlPFC

    5 Dynamic Network Connectivity: Rapid Changes in Network Strength in dlPFC

    6 Activation of Ca2 +–cAMP Signaling in Spines Reduces Firing via Opening of K+ Channels

    7 Inhibition of Ca2 +–cAMP–K+ Signaling in Spines Enhances Task-Related Firing

    8 Dopamine D1R Stimulation Regulates the Breadth of Network Inputs

    9 Conclusion


    Chapter Nine: Cost–Benefit Decision Circuitry

    1 Introduction

    2 General Features of Cost–Benefit Decision Making

    3 The DA System Transmits Reward and Cost Information throughout the Brain

    4 Effort-Based Decision Circuitry

    5 Delay-Based Decision Circuitry

    6 Risk-Based Decision Circuitry

    7 Cholinergic Modulation of Decision Circuitry

    8 Conclusion


    Chapter Ten: Molecular Mechanisms of Threat Learning in the Lateral Nucleus of the Amygdala

    1 Introduction

    2 Hebbian Mechanisms in LA: Possible Contributions to Threat Learning

    3 Molecular Correlates of Threat Learning

    4 Fast Versus Slow Synaptic Transmission in the Acquisition of Threat Memories

    5 Mechanisms of Threat Memory Consolidation in LA

    6 Overall Conclusions

    Chapter Eleven: Epigenetics of Memory and Plasticity

    1 Overview

    2 Background

    3 Brain Plasticity Through Epigenetics

    4 Epigenetics Mechanisms of Learning and Memory Formation

    5 Epigenetics and Cognitive Dysfunctions

    6 Conclusions


    Chapter Twelve: Deciphering Memory Function with Optogenetics

    1 Optogenetics

    2 Optogenetic Manipulation of Memory

    3 Optogenetic-Facilitated Synaptic Dissection of Memory Function

    4 Conclusions


    Chapter Thirteen: The Tagging and Capture Hypothesis from Synapse to Memory

    1 Introduction

    2 The ABC of Tagging and Capture Mechanisms

    3 Which Criteria Should Satisfy a Candidate for a Tag?

    4 Memory Can Be Thought of as Changes in Synaptic Plasticity

    5 Synaptic Plasticity Was Improved In Vivo by Structural or Behavioral Reinforcements

    6 LTM Formation Was Promoted by Synaptic Plasticity and Behavioral Reinforcers

    7 Novelty Promotes LTM Formation in IA and Contextual Fear Tasks

    8 Novelty Promotes LTM Formation in Spatial Memories

    9 Novelty Improves LTM Formation in CTA Task

    10 Specific Novelties Are Required to Promote Different Memory Traces

    11 Identification of Transmitter Systems and Learning Tag Molecules

    12 Memory Traces Compete Under Regimes of Limited Protein Synthesis

    13 Evidence of BT in Human

    14 Concluding Remarks


Product details

  • No. of pages: 468
  • Language: English
  • Copyright: © Academic Press 2014
  • Published: January 30, 2014
  • Imprint: Academic Press
  • Hardcover ISBN: 9780124201705
  • eBook ISBN: 9780124202009

About the Serial Volume Editors

E. Chris Muly

Affiliations and Expertise

Emory University, Atlanta, USA

Zafar Khan

Affiliations and Expertise

Universidad de Málaga, Spain

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