Description

This special volume of Progress in Molecular Biology and Translational Science provides a current overview of how memory is processed in the brain. A broad range of topics are presented by leaders in the field, ranging from brain circuitry to synaptic plasticity to the molecular machinery that contributes to the brain's ability to maintain information across time. Memory systems in the prefrontal cortex, hippocampus and amygdala are considered as well. In addition, the volume covers recent contributions to our understanding of memory from in vivo imaging, optogenetic, electrophysiological, biochemical and molecular biological studies.

Key Features

  • Articles from world renowned experts in memory
  • Covering topics from signaling, epigenetic, RNA translation to  plasticity
  • Methodological approaches include molecular and cellular, behavioral, electrophysiological, optogenetic and functional imaging

Readership

Researchers, professors and graduate students in biochemistry, chemistry, molecular biology, biotechnology, and medicine.

Table of Contents

Contributors
Preface
Chapter One: Memory Deficits in Aging and Neurological Diseases
Abstract

1 Introduction

2 Memory Loss in Aging

3 Memory Deficit in Alzheimer’s Disease

4 Memory Impairment in Schizophrenia

5 Concluding Remarks

Acknowledgments

Chapter Two: The “Memory Kinases”
Abstract

1 Introduction

2 Distribution of PKC Isoforms

3 Structure of PKC Isoforms

4 PKC Isoforms in Signal Transduction

5 PKC Inhibitors

6 PKC Activators

7 Conclusions

Chapter Three: CaMKII
Abstract

1 Memory and Synaptic Plasticity

2 Molecular Mechanisms of LTP

3 Synaptic Architecture

4 Calcium/Calmodulin-Dependent Protein Kinase

5 CaMKII Isoforms

6 CaMKII Holoenzyme

7 CaMKII Regulation

8 CaMKII Targeting

9 AMPAR-Mediated Potentiation

10 CaMKII and LTD

11 Concluding Remarks

Chapter Four: The Transcription Factor Zif268/Egr1, Brain Plasticity, and Memory
Abstract

1 Introduction

2 Zif268 and the Egr Family of Transcription Factors

3 The Role of Zif268 in Synaptic Plasticity

4 The Role of Zif268 in Learning and Memory

5 Adult Neurogenesis: A New Role for Zif268

6 Zif268 in Pathology

7 Conclusions and Perspectives

Acknowledgments

Chapter Five: Mechanisms of Translation Control Underlying Long-Lasting Synaptic Plasticity and the Consolidation of Long-Term Memory
Abstract

1 The Study and Characterization of Memory Systems

2 Mechanisms of mTOR-Dependent Translational Control

3 Translational Control Molecules Involved in Synaptic Plasticity and Memory

4 Concluding Remarks

Chapter Six: BDNF–TrkB Receptor Regulation of Distributed Adult Neural Plasticity, Memory Formation, and Psychiatric Disorders
Abstract

1 Brain-Derived Neurotrophic Factor

Details

No. of pages:
468
Language:
English
Copyright:
© 2014
Published:
Imprint:
Academic Press
Electronic ISBN:
9780124202009
Print ISBN:
Print ISBN:
9780124201705

About the serial-volume-editors

Reviews

Praise for the series:
"Full of interest not only for the molecular biologist-for whom the numerous references will be invaluable-but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell." --British Medical Journal