Molecular Basis of Memory, Volume 122

1st Edition

Print ISBN: 9780124201705
eBook ISBN: 9780124202009
Imprint: Academic Press
Published Date: 14th February 2014
Page Count: 468
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This special volume of Progress in Molecular Biology and Translational Science provides a current overview of how memory is processed in the brain. A broad range of topics are presented by leaders in the field, ranging from brain circuitry to synaptic plasticity to the molecular machinery that contributes to the brain's ability to maintain information across time. Memory systems in the prefrontal cortex, hippocampus and amygdala are considered as well. In addition, the volume covers recent contributions to our understanding of memory from in vivo imaging, optogenetic, electrophysiological, biochemical and molecular biological studies.

Key Features

  • Articles from world renowned experts in memory
  • Covering topics from signaling, epigenetic, RNA translation to  plasticity
  • Methodological approaches include molecular and cellular, behavioral, electrophysiological, optogenetic and functional imaging


Researchers, professors and graduate students in biochemistry, chemistry, molecular biology, biotechnology, and medicine.

Table of Contents

Chapter One: Memory Deficits in Aging and Neurological Diseases

1 Introduction

2 Memory Loss in Aging

3 Memory Deficit in Alzheimer’s Disease

4 Memory Impairment in Schizophrenia

5 Concluding Remarks


Chapter Two: The “Memory Kinases”

1 Introduction

2 Distribution of PKC Isoforms

3 Structure of PKC Isoforms

4 PKC Isoforms in Signal Transduction

5 PKC Inhibitors

6 PKC Activators

7 Conclusions

Chapter Three: CaMKII

1 Memory and Synaptic Plasticity

2 Molecular Mechanisms of LTP

3 Synaptic Architecture

4 Calcium/Calmodulin-Dependent Protein Kinase

5 CaMKII Isoforms

6 CaMKII Holoenzyme

7 CaMKII Regulation

8 CaMKII Targeting

9 AMPAR-Mediated Potentiation

10 CaMKII and LTD

11 Concluding Remarks

Chapter Four: The Transcription Factor Zif268/Egr1, Brain Plasticity, and Memory

1 Introduction

2 Zif268 and the Egr Family of Transcription Factors

3 The Role of Zif268 in Synaptic Plasticity

4 The Role of Zif268 in Learning and Memory

5 Adult Neurogenesis: A New Role for Zif268

6 Zif268 in Pathology

7 Conclusions and Perspectives


Chapter Five: Mechanisms of Translation Control Underlying Long-Lasting Synaptic Plasticity and the Consolidation of Long-Term Memory

1 The Study and Characterization of Memory Systems

2 Mechanisms of mTOR-Dependent Translational Control

3 Translational Control Molecules Involved in Synaptic Plasticity and Memory

4 Concluding Remarks

Chapter Six: BDNF–TrkB Receptor Regulation of Distributed Adult Neural Plasticity, Memory Formation, and Psychiatric Disorders

1 Brain-Derived Neurotrophic Factor</


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Praise for the series:
"Full of interest not only for the molecular biologist-for whom the numerous references will be invaluable-but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell." --British Medical Journal