Molecular Basis of Aging

Molecular Basis of Aging

1st Edition - January 28, 1984

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  • Editor: A Roy
  • eBook ISBN: 9780323151559

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Description

Molecular Basis of Aging is a collection of papers that discuss the molecular aspects of aging in the light of molecular biology, biochemical gerontology, and genetics. Each chapter of the book contains a different study about the topic, which includes the effects of aging on DNA synthesis; the amplification of extrachromosomal circular copies and mitochondrial DNA during aging; and the altered actions of hormones and neurotransmitters during aging. The book also encompasses the loss of responsiveness to growth factors in cell senescence; the integration of cellular-molecular and neuroendocrine concepts of aging; changes and inactivation of enzymes during aging; and the relationship of aging with free radicals. The text is recommended for molecular biologists, biochemists, and gerontologists who wish to study further the effects of aging on the body on a molecular level.

Table of Contents


  • Contributors

    Preface

    Amplification of Extrachromosomal Circular Copies of an Inter-Alu Unstable DNA Sequence during in Vitro and in Vivo Aging

    Site-Specific Excision-Amplification of Mitochondrial DNA 29 during Senescence in Podospora anserina

    Fidelity of DNA Synthesis during Aging

    DNA Excision Repair in Aging Inbred Rats

    DNA Synthesis, Cell Progression, and Aging in Human Diploid Fibroblasts

    Loss of Responsiveness to Growth Factors in Cell Senescence

    Hormonal Regulation of Hepatic Gene Expression during Aging

    Altered Hormone/Neurotransmitter Action during Aging: Receptor and Post-Receptor Changes

    Cellular-Molecular versus Neuroendocrine Concepts of Aging: A Need for Integration

    Changes in Enzymatic Proteins during Aging

    Oxidative Inactivation of Key Metabolie Enzymes during Aging

    Free Radicals and Aging

    Mathematics of Molecular Aging Mechanisms

    Index

Product details

  • No. of pages: 410
  • Language: English
  • Copyright: © Academic Press 1984
  • Published: January 28, 1984
  • Imprint: Academic Press
  • eBook ISBN: 9780323151559

About the Editor

A Roy

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