Molecular Assembly in Natural and Engineered Systems

Molecular Assembly in Natural and Engineered Systems

1st Edition - October 12, 2011

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  • Editor: Stefan Howorka
  • Hardcover ISBN: 9780124159068
  • eBook ISBN: 9780124159297

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This volume explores some of the most exciting recent advances in basic research on molecular assembly in natural and engineered systems and how this knowledge is leading to advances in the various fields.

Key Features

  • This series provides a forum for discussion of new discoveries, approaches, and idea
  • Contributions from leading scholars and industry experts
  • Reference guide for researchers involved in molecular biology and related fields


Researchers, professors and graduate students in biochemistry, chemistry, molecular biology, biotechnology, and medicine.

Table of Contents

  • Contributors


    Chapter 1: Bacterial Microcompartments

    I. Introduction

    II. Bacterial Microcompartment Form and Function

    III. Shell Proteins: Structures and Mechanisms

    IV. Higher-Level Organization

    V. Future Directions for Research and Design Applications

    VI. Closing Remarks

    Chapter 2: Pili and Flagella

    II. Pili in Gram-Negative Bacteria

    III. Pili in Gram-Positive Bacteria

    IV. Surface Filaments in Archaea

    V. Flagella

    VI. Applications

    Chapter 3: The Structure of Bacterial S-Layer Proteins

    II. Geobacillus stearothermophilus

    III. Clostridia

    IV. Lactobacilli

    V. Bacillus anthracis

    VI. Lysinibacillus sphaericus

    VII. Corynebacterium glutamicum

    VIII. Deinococcus–Thermus

    IX. S-Layers from Gram-Negative Bacteria

    X. Concluding Remarks

    Chapter 4: Spider Silk

    II. Spiders

    III. Nomenclature of Silk Types

    IV. Set-up of Silk Proteins

    V. Major Ampullate Silk (aka Dragline Silk, Lifeline Silk) and Minor Ampullate Silk

    VI. Flagelliform Silk (aka Capture Silk and Viscid Silk)

    VII. Pseudoflagelliform Silk and Cribellate Silk

    VIII. Aciniform Silk

    IX. Tubiliform Silk (aka Cylindriform Silk)

    X. Egg Case Proteins

    XI. Aggregate Silk (aka Glue)

    XII. Pyriform Silk

    XIII. Silk Summary

    XIV. Producing Recombinant Silk Proteins

    XV. Future Outlook

    Chapter 5: Protein Modifications Giving Rise to Homo-oligomers

    I. Proteins as Building Blocks

    II. Hetero- Versus Homo-oligomers

    III. Symmetric Associations

    IV. Lessons from Protein Crystallization

    V. The Analysis of Known Protein–Protein Contacts

    VI. Self-assembly in Nature

    VII. Self-assembling Protein Constructs

    VIII. Design of Protein–Protein Contacts

    IX. Future Applications

    Chapter 6: Alpha-Helical Peptide Assemblies

    II. Designing Discrete Helical Assemblies

    III. Designing Higher-Order Helical Assemblies

    IV. Overview and Future Outlook

    Chapter 7: Nanobiotechnology with S-Layer Proteins as Building Blocks

    II. General Principles

    III. Assembly and Morphogenesis of S-Layers

    IV. S-Layers for the Production of Ultrafiltration Membranes

    V. S-Layer as Matrix for the Immobilization of Functional Molecules and Nanoparticles

    VI. S-Layer Fusion Proteins—Construction Principles and Applications

    VII. S-Layers for Vaccine Development

    VIII. S-Layers as Supporting Structure for Functional Lipid Membranes

    IX. S-Layers as Matrix for Biomineralization

    X. Conclusion and Perspectives

    Chapter 8: Viral Capsids as Self-Assembling Templates for New Materials

    II. Covalent Modification of Viral Capsids for Applications in Medical Imaging and Drug Delivery

    III. Viral Capsids as Templates for the Construction of Inorganic Materials

    IV. Capsid-Based Materials for Optical and Catalytic Applications

    V. Summary and Future Challenges


Product details

  • No. of pages: 414
  • Language: English
  • Copyright: © Academic Press 2011
  • Published: October 12, 2011
  • Imprint: Academic Press
  • Hardcover ISBN: 9780124159068
  • eBook ISBN: 9780124159297

About the Serial Volume Editor

Stefan Howorka

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