Molecular Aspects of Bioelectricity

Molecular Aspects of Bioelectricity

1st Edition - January 1, 1980

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  • Editors: Ernest Schoffeniels, Eberhard Neumann
  • eBook ISBN: 9781483189857

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Description

Molecular Aspects of Bioelectricity describes the self-organization in molecular and cellular networks. This book evaluates the chemical representation of ion flux gating in excitable biomembranes and addresses the theoretical implication of liganding reactions in axonal sodium channel gating. It also strongly demonstrates the ligand interactions of crustacean axonal membrane. The opening chapters deal with the biochemical studies of the structure, mechanism, and differentiation of the voltage-sensitive sodium channel; and biochemical cycle of impedance variation in axonal membranes. The succeeding chapters examine the effect of various compounds on the phosphorylation of nerve proteins and the molecular aspects of the actions of cyclic nucleotides at synapses. These topics are followed by discussions of the acetylcholine and choline acetyltransferase, as well as the polymorphism of cholinesterase in vertebrates. The closing chapters are devoted to the physical factors determining gated flux from and into sealed membrane fragments. The book can provide useful information to biologists, students, and researchers.

Table of Contents

  • Conference Organizing Committee

    PREFACE

    Chapter 1: OPENING ADDRESS

    Chapter 2: SESSIONAL CHAIRMAN’s REMARKS

    Chapter 3: CHAIRMAN’S INTRODUCTION TO SESSION

    Chapter 4: INTRODUCTORY REMARKS

    Chapter 5: FROM THE ADDRESS AT THE FAREWELL DINNER IN HONOR OF PROFESSOR DAVID NACHMANSOHN

    Chapter 6: SELFORGANIZATION IN MOLECULAR AND CELLULAR NETWORKS

    ABSTRACT

    Chapter 7: CHEMICAL REPRESENTATION OF ION FLUX GATING IN EXCITABLE BIOMEMBRANES

    ABSTRACT

    INTRODUCTION

    ION FLUX GATING CONCEPT

    ELEMENTAL BIOELECTRICAL SIGNAL

    GATING MACROMOLECULES

    ACETYLCHOLINESTERASE

    AXONAL GATING

    ACKNOWLEDGEMENTS

    Chapter 8: THEORETICAL IMPLICATION OF LIGANDING REACTIONS IN AXONAL SODIUM CHANNEL GATING

    ABSTRACT

    INTRODUCTION

    LIGANDING REACTION IN SODIUM CHANNEL ACTIVATION

    ELECTRICAL-CHEMICAL GATING MODEL

    EVIDENCE FOR CHEMICAL ENERGY INPUT FROM MEMBRANE CAPACITANCE MEASUREMENTS

    CONCLUSION

    ACKNOWLEDGEMENT

    Chapter 9: LIGAND INTERACTIONS OF CRUSTACEAN AXONAL MEMBRANES

    ABSTRACT

    TEXT

    Chapter 10: BIOCHEMICAL STUDIES OF THE STRUCTURE, MECHANISM AND DIFFERENTIATION OF THE VOLTAGE-SENSITIVE SODIUM CHANNEL

    ABSTRACT

    INTRODUCTION

    THE TETRODOTOXIN (OR SAXITOXIN) RECEPTOR

    THE GATING SYSTEM OF THE Na+ CHANNEL

    THE DEVELOPMENTAL PROPERTIES OF THE SODIUM CHANNEL

    ACKNOWLEDGMENTS

    Chapter 11: Na-CHANNELS IN MEMBRANE FRAGMENTS FROM ELECTROPHORUS ELECTRICUS ELECTROPLAQUES: BIOCHEMICAL STUDIES

    ABSTRACT

    INTRODUCTION

    CONCLUSIONS

    ACKNOWLEDGEMENT

    Chapter 12: THE BIOCHEMICAL CYCLE OF IMPEDANCE VARIATION IN AXONAL MEMBRANES

    ABSTRACT

    INTRODUCTION

    METHODS

    RESULTS

    DISCUSSION

    ACKNOWLEDGEMENTS

    Chapter 13: EFFECT OF VARIOUS COMPOUNDS ON THE PHOSPHORYLATION OF NERVE PROTEINS

    ABSTRACT

    INTRODUCTION

    MATERIAL AND METHODS

    RESULTS

    DISCUSSION

    ACKNOWLEDGEMENTS

    Chapter 14: PROTEIN PHOSPHORYLATION IN NERVE AND ELECTRIC ORGAN : ISOLATION AND PARTIAL CHARACTERIZATION OF A HIGH AFFINITY SYSTEM FOR ATP

    ABSTRACT

    INTRODUCTION

    MATERIAL AND METHODS

    RESULTS

    DISCUSSION

    ACKNOWLEDGEMENTS

    Chapter 15: INSEPARABILITY OF ACETYLCHOLINESTERASE AND NERVE EXCITATION

    Publisher Summary

    Chapter 16: MOLECULAR ASPECTS OF THE ACTIONS OF CYCLIC NUCLEOTIDES AT SYNAPSES

    ABSTRACT

    INTRODUCTION

    EXPERIMENTAL STUDY OF PROTEIN PHOSPHORYLATION IN NEURAL TISSUES

    CYCLIC NUCLEOTIDES, PROTEIN PHOSPHORYLATION AND MEMBRANE POLARISATION

    Chapter 17: ACETYLCHOLINE AND CHOLINE ACETYLTRANSFERASE

    ABSTRACT

    INTRODUCTION

    ACETYLCHOLINE AND CHOLINE

    THE MECHANISM OF ACTION OF CHOLINE ACETYLTRANSFERASE

    Chapter 19: CHOLINESTERASES OF NEUROMUSCULAR JUNCTION

    ABSTRACT

    INTRODUCTION

    METHODS AND MATERIALS

    RESULTS AND DISCUSSION

    ACKNOWLEDGEMENTS

    Chapter 20: THE POLYMORPHISM OF CHOLINESTERASE IN VERTEBRATES

    ABSTRACT

    INTRODUCTION

    MULTIPLE MOLECULAR FORMS OF AChE IN ELECTRIC ORGANS

    COLLAGEN-TAILED AND GLOBULAR FORMS OF AChE IN MAMMALIAN TISSUES

    POLYMORPHISM OF MAMMALIAN BuChE. RELATIONSHIP WITH THE MOLECULAR FORMS OF AChE

    AChE AND BuChE FORMS IN CHICKEN

    PHYSIOLOGICAL STATUS OF THE GLOBULAR FORMS

    DISTRIBUTION AND REGULATION OF THE COLLAGEN-TAILED FORMS

    PHYSIOLOGICAL SIGNIFICANCE OF THE POLYMORPHISM OF CHOLINESTERASES

    ACKNOWLEDGEMENTS

    Chapter 21: ELECTRIC-FIELD INDUCED EFFECTS IN ACETYLCHOLINESTERASE

    ABSTRACT

    INTRODUCTION

    MATERIALS AND METHODS

    RESULTS AND DISCUSSION

    CONCLUSIONS

    ACKNOWLEDGEMENT

    Chapter 22: ACETYLCHOLINESTERASE – THE ACYL-ENZYME INTERMEDIATE

    ABSTRACT

    INTRODUCTION

    EXPERIMENTAL

    RESULTS AND DISCUSSION

    Chapter 23: NEW FLUORESCENT ORGANOPHOSPHATES AS PROBES FOR STUDYING AGING-INDUCED CONFORMATIONAL CHANGES IN INHIBITED ACETYLCHOLINESTERASE

    ABSTRACT

    INTRODUCTION

    MATERIALS AND METHODS

    RESULTS AND DISCUSSION

    ACKNOWLEDGEMENTS

    Chapter 24: INTERACTION OF ELECTRIC EEL ACETYLCHOLINESTERASE WITH NATURAL AND SYNTHETIC LIPIDS

    ABSTRACT

    ACKNOWLEDGEMENTS

    Chapter 25: HUMAN BRAIN WEIGHT AND ACETYLCHOLINESTERASE IN RELATION TO AGING

    ABSTRACT

    INTRODUCTION

    METHODS

    RESULTS

    DISCUSSION

    Chapter 26: ACETYLCHOLINESTERASE REACTIVATION IN THE BRAIN OF PARATHION POISONED DOGS

    ABSTRACT

    INTRODUCTION

    MATERIALS AND METHODS

    RESULTS

    DISCUSSION

    REFERENCES

    Chapter 27: FUNCTIONAL PROPERTIES OF THE ACETYLCHOLINE RECEPTOR PROTEIN

    Publisher Summary

    MODEL OF THE ACETYLCHOLINE REGULATOR

    STRUCTURE OF THE SUBSYNAPTIC MEMBRANE

    PROPERTIES OF THE PURIFIED RECEPTOR PROTEIN

    LIGAND BINDING SITES AND ALLOSTERIC TRANSITIONS OF THE ACETYLCHOLINE REGULATOR

    RECONSTITUTION OF A FUNCTIONAL ACETYLCHOLINE REGULATOR

    ACKNOWLEDGEMENTS

    Chapter 28: KINETIC MECHANISM OF ACETYLCHOLINE RECEPTOR-CONTROLLED ION FLUX: FLOW QUENCH KINETIC MEASUREMENTS OF ACETYLCHOLINE-INDUCED FLUX IN MEMBRANE VESICLES

    ABSTRACT

    INTRODUCTION

    MATERIALS AND METHODS

    RESULTS

    (a) Inactivation of the receptor (•)

    Reactivation of the receptor (Δ, )

    (b) Influx mediated by the equilibrium mixture of active and inactive receptor conformations

    (c) Influx of 86Rb+ in presence of various concentrations of carbamylcholine

    DISCUSSION

    ACKNOWLEDGEMENT

    Chapter 29: PHYSICAL FACTORS DETERMINING GATED FLUX FROM OR INTO SEALED MEMBRANE FRAGMENTS

    Publisher Summary

    INTRODUCTION

    THE OVERALL FLUX

    EXPERIMENTAL DETERMINATION OF FLUX PARAMETERS

    THE INTRINSIC FLUX RATE CONSTANT

    (I) Binding of tracer ions is slower than transport

    (II) Transport of tracer ions is faster than binding

    ACKNOWLEDGEMENT

    Chapter 30: ON THE KINETICS OF CHOLINERGIC EXCITATION

    ABSTRACT

    INTRODUCTION

    Chapter 31: INTERACTIONS OF FLUORESCENT CHOLINERGIC ANTAGONISTS WITH THE MEMBRANE-BOUND ACETYLCHOLINE RECEPTOR

    ABSTRACT

    INTRODUCTION

    MATERIALS AND METHODS

    RESULTS AND DISCUSSION

    Acknowledgements

    Chapter 32: FACTORS INFLUENCING THE STABILITY OF ISOLATED ACETYLCHOLINE RECEPTOR FROM TORPEDO californica

    ABSTRACT

    INTRODUCTION

    OLIGOMERS OF ACETYLCHOLINE RECEPTOR

    PHOSPHOLIPID INTERACTION WITH PURIFIED RECEPTOR

    SULFHYDRYL GROUP IN AChR

    ACKNOWLEDGEMENTS

    Chapter 33: QUATERNARY STRUCTURE AND RECONSTITUTION OF ACETYLCHOLINE RECEPTOR FROM TORPEDO CALIFORNICA

    ABSTRACT

    INTRODUCTION

    RESULTS

    ACKNOWLEDGEMENT

    Chapter 34: A NOVEL CONCEPT OF MEMBRANE RECONSTITUTION APPLIED TO ACETYLCHOLINE RECEPTOR FROM TORPEDO AND MATRIX PROTEIN FROM ESCHERICHIA COLI

    ABSTRACT

    INTRODUCTION

    WHAT IS REALLY MEANT BY RECONSTITUTION?

    APPLICATION TO MATRIX PROTEIN FROM E. COLI OUTER MEMBRANES

    APPLICATION TO ACETYLCHOLINE RECEPTOR FROM TORPEDO

    CONCLUSION

    ACKNOWLEDGEMENT

    Chapter 35: GLIAL CONTROL OF NEURONAL EXCITABILITY IN MAMMALS: I. ELECTROPHYSIOLOGICAL AND ISOTOPIC EVIDENCE IN CULTURE

    ABSTRACT

    INTRODUCTION

    MATERIAL AND METHODS

    RESULTS

    DISCUSSION

    Chapter 36: GLIAL CONTROL OF NEURONAL EXCITABILITY IN MAMMALS II. ENZYMATIC EVIDENCE : TWO MOLECULAR FORMS OF THE (Na+,K+)-ATPase IN BRAIN

    ABSTRACT

    INTRODUCTION

    METHODS

    RESULTS

    CONCLUSIONS

    Chapter 38: GLUCOSE TRANSPORT IN CELLS OF THE NERVOUS SYSTEM

    ABSTRACT

    INTRODUCTION

    MATERIALS AND METHODS

    RESULTS

    DISCUSSION

    Chapter 39: DISTRIBUTION OF AN ENDOGENOUS LECTIN DURING MYOGENESIS AS MEASURED BY ANTILECTIN ANTIBODIES

    ABSTRACT

    INTRODUCTION

    DISCUSSION

    ACKNOWLEDGEMENTS

    LIST OF PARTICIPANTS

    INDEX

Product details

  • No. of pages: 362
  • Language: English
  • Copyright: © Pergamon 1980
  • Published: January 1, 1980
  • Imprint: Pergamon
  • eBook ISBN: 9781483189857

About the Editors

Ernest Schoffeniels

Eberhard Neumann

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