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Molecular Aspects of Bioelectricity
- 1st Edition - January 1, 1980
- Editors: Ernest Schoffeniels, Eberhard Neumann
- Language: English
- eBook ISBN:9 7 8 - 1 - 4 8 3 1 - 8 9 8 5 - 7
Molecular Aspects of Bioelectricity describes the self-organization in molecular and cellular networks. This book evaluates the chemical representation of ion flux gating in… Read more
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Request a sales quoteMolecular Aspects of Bioelectricity describes the self-organization in molecular and cellular networks. This book evaluates the chemical representation of ion flux gating in excitable biomembranes and addresses the theoretical implication of liganding reactions in axonal sodium channel gating. It also strongly demonstrates the ligand interactions of crustacean axonal membrane. The opening chapters deal with the biochemical studies of the structure, mechanism, and differentiation of the voltage-sensitive sodium channel; and biochemical cycle of impedance variation in axonal membranes. The succeeding chapters examine the effect of various compounds on the phosphorylation of nerve proteins and the molecular aspects of the actions of cyclic nucleotides at synapses. These topics are followed by discussions of the acetylcholine and choline acetyltransferase, as well as the polymorphism of cholinesterase in vertebrates. The closing chapters are devoted to the physical factors determining gated flux from and into sealed membrane fragments. The book can provide useful information to biologists, students, and researchers.
Conference Organizing Committee
PREFACE
Chapter 1: OPENING ADDRESS
Chapter 2: SESSIONAL CHAIRMAN’s REMARKS
Chapter 3: CHAIRMAN’S INTRODUCTION TO SESSION
Chapter 4: INTRODUCTORY REMARKS
Chapter 5: FROM THE ADDRESS AT THE FAREWELL DINNER IN HONOR OF PROFESSOR DAVID NACHMANSOHN
Chapter 6: SELFORGANIZATION IN MOLECULAR AND CELLULAR NETWORKS
ABSTRACT
Chapter 7: CHEMICAL REPRESENTATION OF ION FLUX GATING IN EXCITABLE BIOMEMBRANES
ABSTRACT
INTRODUCTION
ION FLUX GATING CONCEPT
ELEMENTAL BIOELECTRICAL SIGNAL
GATING MACROMOLECULES
ACETYLCHOLINESTERASE
AXONAL GATING
ACKNOWLEDGEMENTS
Chapter 8: THEORETICAL IMPLICATION OF LIGANDING REACTIONS IN AXONAL SODIUM CHANNEL GATING
ABSTRACT
INTRODUCTION
LIGANDING REACTION IN SODIUM CHANNEL ACTIVATION
ELECTRICAL-CHEMICAL GATING MODEL
EVIDENCE FOR CHEMICAL ENERGY INPUT FROM MEMBRANE CAPACITANCE MEASUREMENTS
CONCLUSION
ACKNOWLEDGEMENT
Chapter 9: LIGAND INTERACTIONS OF CRUSTACEAN AXONAL MEMBRANES
ABSTRACT
TEXT
Chapter 10: BIOCHEMICAL STUDIES OF THE STRUCTURE, MECHANISM AND DIFFERENTIATION OF THE VOLTAGE-SENSITIVE SODIUM CHANNEL
ABSTRACT
INTRODUCTION
THE TETRODOTOXIN (OR SAXITOXIN) RECEPTOR
THE GATING SYSTEM OF THE Na+ CHANNEL
THE DEVELOPMENTAL PROPERTIES OF THE SODIUM CHANNEL
ACKNOWLEDGMENTS
Chapter 11: Na-CHANNELS IN MEMBRANE FRAGMENTS FROM ELECTROPHORUS ELECTRICUS ELECTROPLAQUES: BIOCHEMICAL STUDIES
ABSTRACT
INTRODUCTION
CONCLUSIONS
ACKNOWLEDGEMENT
Chapter 12: THE BIOCHEMICAL CYCLE OF IMPEDANCE VARIATION IN AXONAL MEMBRANES
ABSTRACT
INTRODUCTION
METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
Chapter 13: EFFECT OF VARIOUS COMPOUNDS ON THE PHOSPHORYLATION OF NERVE PROTEINS
ABSTRACT
INTRODUCTION
MATERIAL AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
Chapter 14: PROTEIN PHOSPHORYLATION IN NERVE AND ELECTRIC ORGAN : ISOLATION AND PARTIAL CHARACTERIZATION OF A HIGH AFFINITY SYSTEM FOR ATP
ABSTRACT
INTRODUCTION
MATERIAL AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
Chapter 15: INSEPARABILITY OF ACETYLCHOLINESTERASE AND NERVE EXCITATION
Publisher Summary
Chapter 16: MOLECULAR ASPECTS OF THE ACTIONS OF CYCLIC NUCLEOTIDES AT SYNAPSES
ABSTRACT
INTRODUCTION
EXPERIMENTAL STUDY OF PROTEIN PHOSPHORYLATION IN NEURAL TISSUES
CYCLIC NUCLEOTIDES, PROTEIN PHOSPHORYLATION AND MEMBRANE POLARISATION
Chapter 17: ACETYLCHOLINE AND CHOLINE ACETYLTRANSFERASE
ABSTRACT
INTRODUCTION
ACETYLCHOLINE AND CHOLINE
THE MECHANISM OF ACTION OF CHOLINE ACETYLTRANSFERASE
Chapter 19: CHOLINESTERASES OF NEUROMUSCULAR JUNCTION
ABSTRACT
INTRODUCTION
METHODS AND MATERIALS
RESULTS AND DISCUSSION
ACKNOWLEDGEMENTS
Chapter 20: THE POLYMORPHISM OF CHOLINESTERASE IN VERTEBRATES
ABSTRACT
INTRODUCTION
MULTIPLE MOLECULAR FORMS OF AChE IN ELECTRIC ORGANS
COLLAGEN-TAILED AND GLOBULAR FORMS OF AChE IN MAMMALIAN TISSUES
POLYMORPHISM OF MAMMALIAN BuChE. RELATIONSHIP WITH THE MOLECULAR FORMS OF AChE
AChE AND BuChE FORMS IN CHICKEN
PHYSIOLOGICAL STATUS OF THE GLOBULAR FORMS
DISTRIBUTION AND REGULATION OF THE COLLAGEN-TAILED FORMS
PHYSIOLOGICAL SIGNIFICANCE OF THE POLYMORPHISM OF CHOLINESTERASES
ACKNOWLEDGEMENTS
Chapter 21: ELECTRIC-FIELD INDUCED EFFECTS IN ACETYLCHOLINESTERASE
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
CONCLUSIONS
ACKNOWLEDGEMENT
Chapter 22: ACETYLCHOLINESTERASE – THE ACYL-ENZYME INTERMEDIATE
ABSTRACT
INTRODUCTION
EXPERIMENTAL
RESULTS AND DISCUSSION
Chapter 23: NEW FLUORESCENT ORGANOPHOSPHATES AS PROBES FOR STUDYING AGING-INDUCED CONFORMATIONAL CHANGES IN INHIBITED ACETYLCHOLINESTERASE
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
ACKNOWLEDGEMENTS
Chapter 24: INTERACTION OF ELECTRIC EEL ACETYLCHOLINESTERASE WITH NATURAL AND SYNTHETIC LIPIDS
ABSTRACT
ACKNOWLEDGEMENTS
Chapter 25: HUMAN BRAIN WEIGHT AND ACETYLCHOLINESTERASE IN RELATION TO AGING
ABSTRACT
INTRODUCTION
METHODS
RESULTS
DISCUSSION
Chapter 26: ACETYLCHOLINESTERASE REACTIVATION IN THE BRAIN OF PARATHION POISONED DOGS
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
Chapter 27: FUNCTIONAL PROPERTIES OF THE ACETYLCHOLINE RECEPTOR PROTEIN
Publisher Summary
MODEL OF THE ACETYLCHOLINE REGULATOR
STRUCTURE OF THE SUBSYNAPTIC MEMBRANE
PROPERTIES OF THE PURIFIED RECEPTOR PROTEIN
LIGAND BINDING SITES AND ALLOSTERIC TRANSITIONS OF THE ACETYLCHOLINE REGULATOR
RECONSTITUTION OF A FUNCTIONAL ACETYLCHOLINE REGULATOR
ACKNOWLEDGEMENTS
Chapter 28: KINETIC MECHANISM OF ACETYLCHOLINE RECEPTOR-CONTROLLED ION FLUX: FLOW QUENCH KINETIC MEASUREMENTS OF ACETYLCHOLINE-INDUCED FLUX IN MEMBRANE VESICLES
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
(a) Inactivation of the receptor (•)
Reactivation of the receptor (Δ, )
(b) Influx mediated by the equilibrium mixture of active and inactive receptor conformations
(c) Influx of 86Rb+ in presence of various concentrations of carbamylcholine
DISCUSSION
ACKNOWLEDGEMENT
Chapter 29: PHYSICAL FACTORS DETERMINING GATED FLUX FROM OR INTO SEALED MEMBRANE FRAGMENTS
Publisher Summary
INTRODUCTION
THE OVERALL FLUX
EXPERIMENTAL DETERMINATION OF FLUX PARAMETERS
THE INTRINSIC FLUX RATE CONSTANT
(I) Binding of tracer ions is slower than transport
(II) Transport of tracer ions is faster than binding
ACKNOWLEDGEMENT
Chapter 30: ON THE KINETICS OF CHOLINERGIC EXCITATION
ABSTRACT
INTRODUCTION
Chapter 31: INTERACTIONS OF FLUORESCENT CHOLINERGIC ANTAGONISTS WITH THE MEMBRANE-BOUND ACETYLCHOLINE RECEPTOR
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
Acknowledgements
Chapter 32: FACTORS INFLUENCING THE STABILITY OF ISOLATED ACETYLCHOLINE RECEPTOR FROM TORPEDO californica
ABSTRACT
INTRODUCTION
OLIGOMERS OF ACETYLCHOLINE RECEPTOR
PHOSPHOLIPID INTERACTION WITH PURIFIED RECEPTOR
SULFHYDRYL GROUP IN AChR
ACKNOWLEDGEMENTS
Chapter 33: QUATERNARY STRUCTURE AND RECONSTITUTION OF ACETYLCHOLINE RECEPTOR FROM TORPEDO CALIFORNICA
ABSTRACT
INTRODUCTION
RESULTS
ACKNOWLEDGEMENT
Chapter 34: A NOVEL CONCEPT OF MEMBRANE RECONSTITUTION APPLIED TO ACETYLCHOLINE RECEPTOR FROM TORPEDO AND MATRIX PROTEIN FROM ESCHERICHIA COLI
ABSTRACT
INTRODUCTION
WHAT IS REALLY MEANT BY RECONSTITUTION?
APPLICATION TO MATRIX PROTEIN FROM E. COLI OUTER MEMBRANES
APPLICATION TO ACETYLCHOLINE RECEPTOR FROM TORPEDO
CONCLUSION
ACKNOWLEDGEMENT
Chapter 35: GLIAL CONTROL OF NEURONAL EXCITABILITY IN MAMMALS: I. ELECTROPHYSIOLOGICAL AND ISOTOPIC EVIDENCE IN CULTURE
ABSTRACT
INTRODUCTION
MATERIAL AND METHODS
RESULTS
DISCUSSION
Chapter 36: GLIAL CONTROL OF NEURONAL EXCITABILITY IN MAMMALS II. ENZYMATIC EVIDENCE : TWO MOLECULAR FORMS OF THE (Na+,K+)-ATPase IN BRAIN
ABSTRACT
INTRODUCTION
METHODS
RESULTS
CONCLUSIONS
Chapter 38: GLUCOSE TRANSPORT IN CELLS OF THE NERVOUS SYSTEM
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
Chapter 39: DISTRIBUTION OF AN ENDOGENOUS LECTIN DURING MYOGENESIS AS MEASURED BY ANTILECTIN ANTIBODIES
ABSTRACT
INTRODUCTION
DISCUSSION
ACKNOWLEDGEMENTS
LIST OF PARTICIPANTS
INDEX
- No. of pages: 362
- Language: English
- Edition: 1
- Published: January 1, 1980
- Imprint: Pergamon
- eBook ISBN: 9781483189857
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