Molecular Aspects of Bioelectricity - 1st Edition - ISBN: 9780080263717, 9781483189857

Molecular Aspects of Bioelectricity

1st Edition

Editors: Ernest Schoffeniels Eberhard Neumann
eBook ISBN: 9781483189857
Imprint: Pergamon
Published Date: 1st January 1980
Page Count: 362
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Description

Molecular Aspects of Bioelectricity describes the self-organization in molecular and cellular networks. This book evaluates the chemical representation of ion flux gating in excitable biomembranes and addresses the theoretical implication of liganding reactions in axonal sodium channel gating. It also strongly demonstrates the ligand interactions of crustacean axonal membrane. The opening chapters deal with the biochemical studies of the structure, mechanism, and differentiation of the voltage-sensitive sodium channel; and biochemical cycle of impedance variation in axonal membranes. The succeeding chapters examine the effect of various compounds on the phosphorylation of nerve proteins and the molecular aspects of the actions of cyclic nucleotides at synapses. These topics are followed by discussions of the acetylcholine and choline acetyltransferase, as well as the polymorphism of cholinesterase in vertebrates. The closing chapters are devoted to the physical factors determining gated flux from and into sealed membrane fragments.
The book can provide useful information to biologists, students, and researchers.

Table of Contents

Conference Organizing Committee

PREFACE

Chapter 1: OPENING ADDRESS

Chapter 2: SESSIONAL CHAIRMAN’s REMARKS

Chapter 3: CHAIRMAN’S INTRODUCTION TO SESSION

Chapter 4: INTRODUCTORY REMARKS

Chapter 5: FROM THE ADDRESS AT THE FAREWELL DINNER IN HONOR OF PROFESSOR DAVID NACHMANSOHN

Chapter 6: SELFORGANIZATION IN MOLECULAR AND CELLULAR NETWORKS

ABSTRACT

Chapter 7: CHEMICAL REPRESENTATION OF ION FLUX GATING IN EXCITABLE BIOMEMBRANES

ABSTRACT

INTRODUCTION

ION FLUX GATING CONCEPT

ELEMENTAL BIOELECTRICAL SIGNAL

GATING MACROMOLECULES

ACETYLCHOLINESTERASE

AXONAL GATING

ACKNOWLEDGEMENTS

Chapter 8: THEORETICAL IMPLICATION OF LIGANDING REACTIONS IN AXONAL SODIUM CHANNEL GATING

ABSTRACT

INTRODUCTION

LIGANDING REACTION IN SODIUM CHANNEL ACTIVATION

ELECTRICAL-CHEMICAL GATING MODEL

EVIDENCE FOR CHEMICAL ENERGY INPUT FROM MEMBRANE CAPACITANCE MEASUREMENTS

CONCLUSION

ACKNOWLEDGEMENT

Chapter 9: LIGAND INTERACTIONS OF CRUSTACEAN AXONAL MEMBRANES

ABSTRACT

TEXT

Chapter 10: BIOCHEMICAL STUDIES OF THE STRUCTURE, MECHANISM AND DIFFERENTIATION OF THE VOLTAGE-SENSITIVE SODIUM CHANNEL

ABSTRACT

INTRODUCTION

THE TETRODOTOXIN (OR SAXITOXIN) RECEPTOR

THE GATING SYSTEM OF THE Na+ CHANNEL

THE DEVELOPMENTAL PROPERTIES OF THE SODIUM CHANNEL

ACKNOWLEDGMENTS

Chapter 11: Na-CHANNELS IN MEMBRANE FRAGMENTS FROM ELECTROPHORUS ELECTRICUS ELECTROPLAQUES: BIOCHEMICAL STUDIES

ABSTRACT

INTRODUCTION

CONCLUSIONS

ACKNOWLEDGEMENT

Chapter 12: THE BIOCHEMICAL CYCLE OF IMPEDANCE VARIATION IN AXONAL MEMBRANES

ABSTRACT

INTRODUCTION

METHODS

RESULTS

DISCUSSION

ACKNOWLEDGEMENTS

Chapter 13: EFFECT OF VARIOUS COMPOUNDS ON THE PHOSPHORYLATION OF NERVE PROTEINS

ABSTRACT

INTRODUCTION

MATERIAL AND METHODS

RESULTS

DISCUSSION

ACKNOWLEDGEMENTS

Chapter 14: PROTEIN PHOSPHORYLATION IN NERVE AND ELECTRIC ORGAN : ISOLATION AND PARTIAL CHARACTERIZATION OF A HIGH AFFINITY SYSTEM FOR ATP

ABSTRACT

INTRODUCTION

MATERIAL AND METHODS

RESULTS

DISCUSSION

ACKNOWLEDGEMENTS

Chapter 15: INSEPARABILITY OF ACETYLCHOLINESTERASE AND NERVE EXCITATION

Publisher Summary

Chapter 16: MOLECULAR ASPECTS OF THE ACTIONS OF CYCLIC NUCLEOTIDES AT SYNAPSES

ABSTRACT

INTRODUCTION

EXPERIMENTAL STUDY OF PROTEIN PHOSPHORYLATION IN NEURAL TISSUES

CYCLIC NUCLEOTIDES, PROTEIN PHOSPHORYLATION AND MEMBRANE POLARISATION

Chapter 17: ACETYLCHOLINE AND CHOLINE ACETYLTRANSFERASE

ABSTRACT

INTRODUCTION

ACETYLCHOLINE AND CHOLINE

THE MECHANISM OF ACTION OF CHOLINE ACETYLTRANSFERASE

Chapter 19: CHOLINESTERASES OF NEUROMUSCULAR JUNCTION

ABSTRACT

INTRODUCTION

METHODS AND MATERIALS

RESULTS AND DISCUSSION

ACKNOWLEDGEMENTS

Chapter 20: THE POLYMORPHISM OF CHOLINESTERASE IN VERTEBRATES

ABSTRACT

INTRODUCTION

MULTIPLE MOLECULAR FORMS OF AChE IN ELECTRIC ORGANS

COLLAGEN-TAILED AND GLOBULAR FORMS OF AChE IN MAMMALIAN TISSUES

POLYMORPHISM OF MAMMALIAN BuChE. RELATIONSHIP WITH THE MOLECULAR FORMS OF AChE

AChE AND BuChE FORMS IN CHICKEN

PHYSIOLOGICAL STATUS OF THE GLOBULAR FORMS

DISTRIBUTION AND REGULATION OF THE COLLAGEN-TAILED FORMS

PHYSIOLOGICAL SIGNIFICANCE OF THE POLYMORPHISM OF CHOLINESTERASES

ACKNOWLEDGEMENTS

Chapter 21: ELECTRIC-FIELD INDUCED EFFECTS IN ACETYLCHOLINESTERASE

ABSTRACT

INTRODUCTION

MATERIALS AND METHODS

RESULTS AND DISCUSSION

CONCLUSIONS

ACKNOWLEDGEMENT

Chapter 22: ACETYLCHOLINESTERASE – THE ACYL-ENZYME INTERMEDIATE

ABSTRACT

INTRODUCTION

EXPERIMENTAL

RESULTS AND DISCUSSION

Chapter 23: NEW FLUORESCENT ORGANOPHOSPHATES AS PROBES FOR STUDYING AGING-INDUCED CONFORMATIONAL CHANGES IN INHIBITED ACETYLCHOLINESTERASE

ABSTRACT

INTRODUCTION

MATERIALS AND METHODS

RESULTS AND DISCUSSION

ACKNOWLEDGEMENTS

Chapter 24: INTERACTION OF ELECTRIC EEL ACETYLCHOLINESTERASE WITH NATURAL AND SYNTHETIC LIPIDS

ABSTRACT

ACKNOWLEDGEMENTS

Chapter 25: HUMAN BRAIN WEIGHT AND ACETYLCHOLINESTERASE IN RELATION TO AGING

ABSTRACT

INTRODUCTION

METHODS

RESULTS

DISCUSSION

Chapter 26: ACETYLCHOLINESTERASE REACTIVATION IN THE BRAIN OF PARATHION POISONED DOGS

ABSTRACT

INTRODUCTION

MATERIALS AND METHODS

RESULTS

DISCUSSION

REFERENCES

Chapter 27: FUNCTIONAL PROPERTIES OF THE ACETYLCHOLINE RECEPTOR PROTEIN

Publisher Summary

MODEL OF THE ACETYLCHOLINE REGULATOR

STRUCTURE OF THE SUBSYNAPTIC MEMBRANE

PROPERTIES OF THE PURIFIED RECEPTOR PROTEIN

LIGAND BINDING SITES AND ALLOSTERIC TRANSITIONS OF THE ACETYLCHOLINE REGULATOR

RECONSTITUTION OF A FUNCTIONAL ACETYLCHOLINE REGULATOR

ACKNOWLEDGEMENTS

Chapter 28: KINETIC MECHANISM OF ACETYLCHOLINE RECEPTOR-CONTROLLED ION FLUX: FLOW QUENCH KINETIC MEASUREMENTS OF ACETYLCHOLINE-INDUCED FLUX IN MEMBRANE VESICLES

ABSTRACT

INTRODUCTION

MATERIALS AND METHODS

RESULTS

(a) Inactivation of the receptor (•)

Reactivation of the receptor (Δ, )

(b) Influx mediated by the equilibrium mixture of active and inactive receptor conformations

(c) Influx of 86Rb+ in presence of various concentrations of carbamylcholine

DISCUSSION

ACKNOWLEDGEMENT

Chapter 29: PHYSICAL FACTORS DETERMINING GATED FLUX FROM OR INTO SEALED MEMBRANE FRAGMENTS

Publisher Summary

INTRODUCTION

THE OVERALL FLUX

EXPERIMENTAL DETERMINATION OF FLUX PARAMETERS

THE INTRINSIC FLUX RATE CONSTANT

(I) Binding of tracer ions is slower than transport

(II) Transport of tracer ions is faster than binding

ACKNOWLEDGEMENT

Chapter 30: ON THE KINETICS OF CHOLINERGIC EXCITATION

ABSTRACT

INTRODUCTION

Chapter 31: INTERACTIONS OF FLUORESCENT CHOLINERGIC ANTAGONISTS WITH THE MEMBRANE-BOUND ACETYLCHOLINE RECEPTOR

ABSTRACT

INTRODUCTION

MATERIALS AND METHODS

RESULTS AND DISCUSSION

Acknowledgements

Chapter 32: FACTORS INFLUENCING THE STABILITY OF ISOLATED ACETYLCHOLINE RECEPTOR FROM TORPEDO californica

ABSTRACT

INTRODUCTION

OLIGOMERS OF ACETYLCHOLINE RECEPTOR

PHOSPHOLIPID INTERACTION WITH PURIFIED RECEPTOR

SULFHYDRYL GROUP IN AChR

ACKNOWLEDGEMENTS

Chapter 33: QUATERNARY STRUCTURE AND RECONSTITUTION OF ACETYLCHOLINE RECEPTOR FROM TORPEDO CALIFORNICA

ABSTRACT

INTRODUCTION

RESULTS

ACKNOWLEDGEMENT

Chapter 34: A NOVEL CONCEPT OF MEMBRANE RECONSTITUTION APPLIED TO ACETYLCHOLINE RECEPTOR FROM TORPEDO AND MATRIX PROTEIN FROM ESCHERICHIA COLI

ABSTRACT

INTRODUCTION

WHAT IS REALLY MEANT BY RECONSTITUTION?

APPLICATION TO MATRIX PROTEIN FROM E. COLI OUTER MEMBRANES

APPLICATION TO ACETYLCHOLINE RECEPTOR FROM TORPEDO

CONCLUSION

ACKNOWLEDGEMENT

Chapter 35: GLIAL CONTROL OF NEURONAL EXCITABILITY IN MAMMALS: I. ELECTROPHYSIOLOGICAL AND ISOTOPIC EVIDENCE IN CULTURE

ABSTRACT

INTRODUCTION

MATERIAL AND METHODS

RESULTS

DISCUSSION

Chapter 36: GLIAL CONTROL OF NEURONAL EXCITABILITY IN MAMMALS II. ENZYMATIC EVIDENCE : TWO MOLECULAR FORMS OF THE (Na+,K+)-ATPase IN BRAIN

ABSTRACT

INTRODUCTION

METHODS

RESULTS

CONCLUSIONS

Chapter 38: GLUCOSE TRANSPORT IN CELLS OF THE NERVOUS SYSTEM

ABSTRACT

INTRODUCTION

MATERIALS AND METHODS

RESULTS

DISCUSSION

Chapter 39: DISTRIBUTION OF AN ENDOGENOUS LECTIN DURING MYOGENESIS AS MEASURED BY ANTILECTIN ANTIBODIES

ABSTRACT

INTRODUCTION

DISCUSSION

ACKNOWLEDGEMENTS

LIST OF PARTICIPANTS

INDEX

Details

No. of pages:
362
Language:
English
Copyright:
© Pergamon 1980
Published:
Imprint:
Pergamon
eBook ISBN:
9781483189857

About the Editor

Ernest Schoffeniels

Eberhard Neumann