Molecular Aspects of Animal Development

Molecular Aspects of Animal Development

1st Edition - January 1, 1975

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  • Editor: Rudolf Weber
  • eBook ISBN: 9781483272719

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The Biochemistry of Animal Development, Volume III: Molecular Aspects of Animal Development provides an account of the developments in the molecular approach to vertebrate development with particular emphasis on the functions of nucleic acids. The book discusses topics on oocyte maturation, transcriptional patterns in early development, the post-transcriptional control of gene expression, and the significance of gene amplification. Morphogenetic substances, growth-promoting proteins, and the functional differentiation of mitochondria in embryonic systems are covered as well. Biochemists, biologists, and zoologists will find the book invaluable.

Table of Contents

  • Contributors to Volume III


    Contents of Previous Volumes

    Chapter 1 Molecular Events During Oocyte Maturation

    I. Introduction

    II. The Induction of Maturation

    III. Morphological Events of Maturation and Their Relationship to Early Development

    IV. Macromolecular Synthesis during Maturation

    V. Characterization of Hormone-Oocyte Interactions in the Induction of Maturation

    VI. Concluding Comments


    Chapter 2 Transcriptional Patterns in Early Mammalian Development

    I. General Introduction

    II. Onset of Gene Activity in Preimplantation Mammalian Embryos

    III. RNA Containing Poly(A) Sequences in Preimplantation Rabbit Embryos

    IV. Complexity of Transcription in Developing Mammals

    V. Mechanisms of Transcriptional Control

    VI. Relationship of Transcriptional Changes to the General Biochemistry of the Preimplantation Embryo

    VII. Concluding Remarks


    Chapter 3 Occurrence and Developmental Significance of Gene Amplification

    I. Introduction

    II. Gene Amplification Versus Gene Reiteration

    III. Occurrence of Gene Amplification

    IV. Visualization of Gene Amplification

    V. Possible Mechanisms of Gene Amplification

    VI. Theories on Developmental Significance

    VII. Summary and Concluding Remarks


    Chapter 4 The Injection of RNA into Living Cells: The Use of Frog Oocytes for the Assay of mRNA and the Study of the Control of Gene Expression

    I. Introduction

    II. The Translation and Assay of mRNA's

    III. Quantitative Studies: The Efficiency of Translation of Injected mRNA

    IV. The Fidelity of Translation of Injected mRNA's

    V. The Specificity of the Translational Machinery of the Oocyte

    VI. The Post-Translational Modification of Messenger Products

    VII. mRNA Injection as a Means for Analyzing the Translational Systems of the Living Cell

    VIII. Translation of mRNA-Precursor Molecules


    Chapter 5 Post-Transcriptional Control of Protein Synthesis

    I. Introduction

    II. Evidence for Translational Control of Protein Synthesis in Bacteria

    III. Evidence for Post-Transcriptional Control of Protein Synthesis in Animal Cells

    IV. Concluding Remarks


    Chapter 6 The Control of Isoenzyme Patterns in Development

    I. Introduction

    II. Isoenzyme Biochemistry: A General Introduction

    III. Isoenzyme Distribution

    IV. Mechanisms of Control of Isoenzyme Expression During Development

    V. Concluding Remarks


    Chapter 7 Substances with Morphogenetic Activity in Differentiation of Vertebrates

    I. Introduction

    II. Determination, Differentiation, and Competence

    III. Evidence for the Existence of Special Morphogenetic Factors

    IV. Chemical Properties, Biological Activity, and Mechanism of Action of Morphogenetic Substances Effective in Early Embryogenesis

    V. Induction and Determination in Normogenesis of Amphibian Embryos

    VI. Stimulation of Hematopoiesis

    VII. Nerve Growth Stimulating and Epithelial Growth Stimulating Factors

    VIII. Concluding Remarks


    Chapter 8 Protein Nutrition in Growth Regulation during Early Development

    I. Introduction

    II. The Requirement of Embryos for Nutrient Protein

    III. The Requirement of Embryos for Specific Nutrient Proteins

    IV. Nutrient Protein Complementation

    V. Quantitative Analysis of Protein Utilization

    VI. Protein Deprivation during Early Development


    Chapter 9 Mitochondrial Differentiation during Animal Development

    I. Introduction

    II. Structure of Mitochondria

    III. Enzyme Content of Mitochondria

    IV. Mitochondrial Differentiation

    V. Concluding Statement


    Chapter 10 Occurrence and Possible Functions of Mitochondrial DNA in Animal Development

    I. Introduction

    II. Cytoplasmic DNA

    III. Replication and Stability of mt DNA

    IV. Transcription of mt DNA

    V. Mitochondrial Protein Synthesis

    VI. The Possible Results of Interfering with the Mammalian Mitochondrial Genome

    VII. Concluding Remarks


    Author Index

    Index to Genus and Species Names

    Subject Index

Product details

  • No. of pages: 525
  • Language: English
  • Copyright: © Academic Press 1975
  • Published: January 1, 1975
  • Imprint: Academic Press
  • eBook ISBN: 9781483272719

About the Editor

Rudolf Weber

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