Key Features

Detailed review of the molecular anatomy and pathophysiology of the nephron that provides relevant basic science to consider when diagnosing and managing patients with these disorders.

Table of Contents

I. THE TOOLS OF MOLECULAR NEPHROLOGY

1. The impact of Genetics and Genomics on Renal Science and Renal Medicine, Martin Pollak, David Mount

2. Manipulation of the Mouse Genome: Studying Renal Function and Disease, Alexander Gawlik, Susan E. Quaggin

3. Cardiorenal Physiology of the Mouse: From Loss of Genome to Gain of Phenome, Jurgen Schnermann, John N. Lorenz, Josie P. Briggs

4. Murine Modeling of Kidney Development, Jordan A. Kreidberg

II. GENETIC DISORDERS OF RENAL GROWTH AND STRUCTURE

5. Hereditary Disorders of Renal and Urogenital Development, Susan M. Kiefer, Sabiha M. Hussain, Michael Rauchman

6. Autosomal Polycystic Kidney Disease (ADPKD), Jing Zhou, York Pei

7. Autosomal Recessive Polycystic Kidney Disease (ARPKD), Peter C. Harris, Vincente E. Torres

8. Pathogenesis of Nephronophthisis and Medullary Cystic Kidney Disease Thomas Benzing, Gerd Walz

III. GENETIC DISORDERS OF RENAL FUNCTION

9. Hereditary Nephroses, Martin Pollak

10. Molecular and Genetic Basis of Alport Syndrome, Sai Ram Keithi-Reddy, Raghu Kalluri

11. Nail-Patella Syndrome, Ralph Witzgall

12. Primary Hyperoxalurias: Molecular and Clinical Insights, Carla F. Monico, Gillian Rumbsy, Dawn S. Milliner

13. Fabry Disease, James A. Shayman , Paul D. Killen

14. Hereditary Disorders of the Proximal Tubule, David Mount

15. Hereditary Disorders of the Thick Ascending Limb and Distal Convoluted Tubule, Martin Konrad, Rodo O. von Vigier, Siegfried Waldegger

16. Hereditary Disorders of Distal Nephron Sodium and Potassium Transport, David Elisson, Christie Thomas

17. Hereditary Renal Tubular Acidosis, Christine E. Kurschat, Seth L. Alper

18. Hereditary Causes of Nephrogenic Diabetes Insipidus, Peter M.T. Deen, Joris H. Robben, Nine V.A.M. Knoers

19. Genetic Disorders of Calcium and Phosphate Homeosta

Details

No. of pages:
592
Language:
English
Copyright:
© 2008
Published:
Imprint:
Saunders
eBook ISBN:
9781437710373
Print ISBN:
9781416002529

About the authors

David Mount

Affiliations and Expertise

Harvard Medical School, Boston, MA

Martin Pollak

Affiliations and Expertise

Harvard Medical School, Boston, MA, USA