Molecular and Cellular Mechanisms of Neuronal Plasticity in Normal Aging and Alzheimer's Disease - 1st Edition - ISBN: 9780444811219, 9780080862118

Molecular and Cellular Mechanisms of Neuronal Plasticity in Normal Aging and Alzheimer's Disease, Volume 86

1st Edition

Editors: P.D. Coleman G.A. Higgins C.H. Phelps
eBook ISBN: 9780080862118
Imprint: Elsevier Science
Published Date: 14th December 1990


This product is currently not available for sale.

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.

Table of Contents

List of contributors. Preface. Section I. Introductory Overview. Neural plasticity in aging and Alzheimer's disease: Some selected comments (C.H. Phelps). Section II. Cell Death. Glucocorticoids, hippocampal damage and the glutamatergic synapse (R.M. Saplosky). Hormones and programmed cell death: Insights from invertebrate studies (J.W. Truman, S.E. Fahrbach and K. Kimura). Excitotoxin-mediated neuron death in young and old age (J.W. Olney). Section III. Plasticity in Normal and Aging Systems and in AD. Plasticity of excitatory amino acid receptors: Implications for aging and Alzheimer's disease (C.W. Cotman, J.W. Geddes, J. Ulas and T. Klein). Neurono-glial interactions and neural plasticity (G. Moonen, B. Rogister, P. Leprince, J.-P. Rigo, P. Delrée, P.P. Lefèbvre and J. Schoenen). Neuronal plasticity in normal aging and deficient plasticity in Alzheimer's disease: A proposed intercellular signal cascade (P.D. Coleman, K.E. Rogers and D.G. Flood). Effects of aging on the dynamics of information processing and synaptic weight changes in the mammalian hippocampus (C.A. Barnes). Synaptic plasticity and behavioral modifications in the marine mollusk Aplysia (V.F. Castellucci and S. Schacher). Integration by the neuronal growth cone: A continuum from neuroplasticity to neuropathology (S.B. Kater, P.B. Guthrie and L.R. Mills). Intracortical processes regulating the integration of sensory information (F.F. Ebner and M.A. Armstrong-James). Section IV. Intercellular Mechanisms: Growth Factors and Their Receptors. Selective and non-selective trophic actions on central cholinergic and dopaminergic neurons in vitro (F. Hefti, B. Knusel and P.P. Michel). Neurotrophic factors in the CNS: Biosynthetic processing and functional responses (R.A. Bradshaw, J.G. Altin, M. Blaber, K.P. Cavanaugh, D.D. Eveleth, H.I. Kornblum, F.M. Leslie and S. Raffioni). S100-beta as a neurotrophic factor (D.R. Marshak). Growth factor-mediated protection in aging CNS (K. Werrbach-Perez, G. Jackson, D. Marchetti, B. Morgan, L. Thorpe and J.R. Perez-Polo). The brain nicotinic acetylcholine receptor gene family (S. Heinemann, J. Boulter, E. Deneris, J. Connolly, R. Duvoisin, R. Papke and J. Patrick). Gene therapy in the CNS: Intracerebral grafting of genetically modified cells (F.H. Gage, M.B. Rosenberg, M.H. Tuszynski, K. Yoshida, D.M. Armstrong, R.C. Hayes and T. Friedmann). Section V. Intracellar Molecular Mechanisms. Receptors, phosphoinositol hydrolysis and plasticity of nerve cells (N.J. Pontzer, L.J. Chandler, B.R. Stevens and F.T. Crews). Nerve growth factor induces gene expression of the prion protein and beta-amyloid protein precursor in the developing central nervous system (M.P. McKinley, F.M. Longo, J.S. Valletta, F. Rahbar, R. Neve, S.B. Prusiner and W.C. Mobley). Trophic regulation of basal forebrain gene expression in aging and Alzheimer's disease (G.A. Higgins, S. Koh, R.L. Neve, E.J. Mufson, K.S. Chen and F.H. Gage). Genetics and biology of the Alzheimer amyloid precursor (R.L. Neve, L.R. Dawes, B.A. Yankner, L.I. Benowitz, W. Rodriguez and G.A. Higgins). Receptor-effector coupling by G-proteins: Implications for Neuronal plasticity (A.M. Spiegel). Regulation of immediate early genes in brain: Role of NMDA receptor activation (P.F. Worley, A.J. Cole, D.W. Saffen and J.M. Baraban). Inducible proto-oncogenes of the nervous system: Their contribution to transcription factors and neuroplasticity (J.I. Morgan and T. Curran). Section VI. Gene Expression During Normal and Abnormal Neuronal Growth. Neuronal responses to injury and aging: Lessons from animal models (D.L. Price, E.H. Koo, S.S. Sisodia, L.J. Martin, V.E. Koliatsos, N.A. Muma, L.C. Walker and L.C. Cork). GAP-43 as a marker for structural plasticity in the mature CNS (L.I. Benowitz, N.I. Perrone-Bizzozero, R.L. Neve and W. Rodriguez). Increased expression of the major embryonic alpha-tubulin mRNA, T-alpha-1, during neuronal regeneration, sprouting, and in Alzheimer's disease (F.D. Miller and J.W. Geddes). Adhesion and the in vitro development of axons and dendrites (A. Prochiantz, A. Rousselet and B. Chamak). Section VII. Finale. A systems approach to aging, Alzheimer's disease, and spinal cord regeneration (E. Roberts). Subject index. Imprint: Elsevier Amsterdam


Neuroscientists and researchers in Alzheimer's disease will find this book essential reading.


© Elsevier Science 1990
Elsevier Science
eBook ISBN:

About the Editors

P.D. Coleman Editor

G.A. Higgins Editor

C.H. Phelps Editor