Contents. List of Contributors. Preface (E.E. Bittar and N. Bittar). The Nucleosome (R.D. Kornberg). DNA Replication and its Control (J.. blow and J.P.J. Chong). DNA Methylation (R.L.P. Adams). Role of Histones and their Acetylation in Control of Gene Expression (B.M. Turner). Protein-Nucleic Acid Recognition and Interactions (A. Vrielink and P.S. Freemont). Transcription Factors (D.S. Latchman). Alternative RNA Splicing (D.S. Latchman). Antisense RNA and DNA as Potential Therapeutic Agents (L.J. Van Eldik). Regulation of Gene Expression and Gene Amplification (J.D. Hawkins and I.R. Philips). Signal Transduction to the Cell Nucleus (E.A. Nigg). DNA DAmage and Its REpair (A.R. Collins). The Nature and Significance of Mutations (A.R. Collins). The Polymerase Chain Reaction (K.A. Eidne and E. Faccenda). Molecular Cloning (K.A. Eidne). DNA Probes in Human Diseases (P.M. Brickell). Advances in Clinical Genetics (R.S. Verma). The Genome Project-A Commentary (D.R.J. Macer). Transgenic Regulation in Laboratory Animals (S. Rusconi). Index.