Molecular and Cellular Changes in the Cancer Cell

Part I: Overview: Genetic, Epigenetic and Cell Signaling Alterations

• Chapter One: Molecular and Cellular Changes During Cancer Progression Resulting From Genetic and Epigenetic Alterations
  • Abstract
  • 1 Introduction
  • 2 DNA Methylation
  • 3 Lysine Acetylation
  • 4 Lysine and Arginine Methylation
  • 5 Noncoding RNA
  • 6 Epigenetic Readers
  • 7 Concluding Remarks
• Chapter Two: Wnt/β Catenin-Mediated Signaling Commonly Altered in Colorectal Cancer
  • Abstract
  • 1 Wnt Signaling in Colorectal Cancer
  • 2 Mutations in the Wnt Signaling Pathway
  • 3 Cancer Stem Cells
  • 4 Treatments
  • 5 Markers for Early Detection and Prognosis
  • 6 Summary
• Chapter Three: Interplay Between Inflammation and Epigenetic Changes in Cancer
  • Abstract
  • 1 Introduction
  • 2 Complex Relationship Between the Immune System and Cancer
  • 3 Chronic Inflammatory Diseases Predispose Individuals to Cancer
  • 4 Overview of Epigenetics and Its Role in Normal Physiological Processes and Cancer
  • 5 The Role of Inflammation in Initiating Epigenetic Alterations
  • 6 Cancer Prevention and Treatment
  • 7 Concluding Remarks

Part II: Viral Influences in Cancer Initiation and Progression

• Chapter Four: Viral Carcinogenesis
  • Abstract
  • 1 RNA Retroviruses
  • 2 DNA Viruses
  • 3 RNA Viruses
  • 4 Conclusion
• Chapter Five: The Interaction Between Human Papillomaviruses and the Stromal Microenvironment
  • Abstract
  • 1 Introduction
  • 2 The Stromal Microenvironment
  • 3 The HPV Life Cycle
  • 4 Growth Factors
  • 5 Fibroblasts
  • 6 Immune Interactions
  • 7 Angiogenesis and the Hypoxic Response
  • 8 ECM and MMPs
  • 9 Unresolved Questions

Part III: Pancreatic Cancer: Altered Signaling Networks and Emerging Treatment Strategies

• Chapter Six: Molecular Pathogenesis of Pancreatic Cancer
  • Abstract
  • 1 Introduction
  • 2 Genetic Alterations in Pancreatic Cancer
  • 3 Deregulated EMT in Pancreatic Cancer
  • 4 Molecular Subtype Classifications of Pancreatic Cancer
  • 5 Deregulated Signaling Networks in Pancreatic Cancer
  • 6 Current and Future Therapeutic Strategies for Pancreatic Cancer
  • 7 Conclusions
• Chapter Seven: Current and Emerging Targeting Strategies for Treatment of Pancreatic Cancer
  • Abstract
  • 1 Introduction
  • 2 Current Therapeutic Strategies
  • 3 Novel and Emerging Therapeutic Options
  • 4 Concluding Remarks

Part IV: Soft Tissue Sarcomas: Genomic and Epigenomic Alterations

• Chapter Eight: Molecular Changes Associated With Tumor Initiation and Progression of Soft Tissue Sarcomas: Targeting the Genome and Epigenome
  • Abstract
  • 1 Introduction
  • 2 Clinical Parameters of EWSR1-Translocation-Associated Soft Tissue Sarcoma Subtypes
  • 3 Developing Novel Molecular Therapeutic Strategies for the Treatment of EWSR1 Translocation Soft Tissue Sarcoma Subtypes
  • 4 Discussion

Part V: Leukemias: Molecular Changes and Treatment Strategies

• Chapter Nine: Molecular Changes During Acute Myeloid Leukemia (AML) Evolution and Identification of Novel Treatment Strategies Through Molecular Stratification
  • Abstract
  • 1 Acute Myeloid Leukemia
  • 2 Challenges in AML Treatment Stem From Disease Heterogeneity
  • 3 Targeted Chemotherapy and Mechanism Based, Targeted Drug Discovery in AML
  • 4 Combinatorial Control and Discovery of Relevant Drug Combinations
  • 5 Combination Chemotherapy as a Way to Overcome Challenges in AML Treatment
  • 6 Summary
  • Acknowledgments
• Chapter Ten: Myeloproliferative Neoplasms: Molecular Drivers and Therapeutics
  • Abstract
  • 1 Myeloproliferative Neoplasms
  • 2 Etiologic Driver and Nondriver Mutations in MPNs
  • 3 Molecular Biology of MPN Driver Mutations
  • 4 MPN Therapeutics
  • 5 Concluding Remarks

Part VI: Breast Cancer: Endocrine Signaling, Resistance to Endocrine Therapy and Novel Contributors to Pathology

• Chapter Eleven: Dysregulation of Aromatase in Breast, Endometrial, and Ovarian Cancers: An Overview of Therapeutic Strategies
  • Abstract
  • 1 Introduction
  • 2 Aromatase and Estrogen Biosynthesis
  • 3 Expression of Aromatase in Normal and Pathological Human Tissues
  • 4 Estrogen and Its Receptors in Hormone Responsive Cancers
  • 5 Aberrant Expression of Aromatase in Three Common Women's Cancers
  • 7 Understanding of the Role HDAC Inhibitors in Common Women's Cancers
  • 8 Summary and Conclusions
• Chapter Twelve: Molecular Changes During Breast Cancer and Mechanisms of Endocrine Therapy Resistance
  • Abstract
  • 1 Introduction
  • 2 Estrogen Receptors
  • 3 Mechanisms of Endocrine Therapy Resistance
• Chapter Thirteen: Molecular and Cellular Changes in Breast Cancer and New Roles of lncRNAs in Breast Cancer Initiation and Progression
• Abstract
• 1 Introduction
• 2 Identifying lncRNA Signals in the Cancer Transcriptome
• 3 Functions of lncRNAs in Breast Cancer
• 4 Approaches for RNA-Targeted Therapeutic Intervention
• 5 Concluding Remarks
• Acknowledgments