Molecular and Cellular Basis of Metastasis: Road to Therapy - 1st Edition - ISBN: 9780128041406, 9780128041581

Molecular and Cellular Basis of Metastasis: Road to Therapy, Volume 132

1st Edition

Serial Volume Editors: Danny Welch Paul Fisher
eBook ISBN: 9780128041581
Hardcover ISBN: 9780128041406
Imprint: Academic Press
Published Date: 1st September 2016
Page Count: 390
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Table of Contents

  1. Imaging of metastases
      Paul B. Fisher
    2. Dormancy
      Julio Aguirre-Ghiso
    3. Host genetics regulating metastasis
      Kent Hunter and Nigel Crawford
    4. BRMS1
      Douglas R. Hurst, Christa Manton and Danny R. Welch
    5. Immune regulation of metastasis
      Brian Ruffell
    6. microRNA and metastasis
      Li Ma
    7. Different mechanisms of tumor migration
      Peter Friedl
    8. Cytokine regulation of metastasis/tumorigenicity
      Nikki Cheng

Description

Molecular and Cellular Basis of Metastasis: Road to Therapy, the latest in the Advances in Cancer Research series, provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics, with this volume covering the molecular and cellular basis of metastasis.

Key Features

  • Presents groundbreaking information on the molecular and cellular basis of metastasis
  • Provides information on cancer research
  • Outstanding and original reviews
  • Suitable for both researchers and students

Readership

Researchers and students in the basic and clinical sciences of cancer biology and oncology, plus related areas in genetics, immunology, pharmacology, cell biology, and molecular biology


Details

No. of pages:
390
Copyright:
© Academic Press 2016
Published:
Imprint:
Academic Press
eBook ISBN:
9780128041581
Hardcover ISBN:
9780128041406

Reviews

Praise for the Serial:
"This classic and essential series presents critical overviews on select aspects of both cancer research and the basic underlying sciences." --American Scientist
"Excellent, highly informative, in-depth reviews…expertly written, up-to-date, and well-referenced." --Journal of Medicinal Chemistry
"This is a series that has a long tradition of excellence in the field of cancer biology." --Doody’s Publishing Reviews

Ratings and Reviews


About the Serial Volume Editors

Danny Welch Serial Volume Editor

University of Kansas Cancer Center, USA

Affiliations and Expertise

University of Kansas Cancer Center, USA

Paul Fisher Serial Volume Editor

Paul B. Fisher, M.Ph., Ph.D., is an accomplished molecular biologist investigating the mechanisms involved in cancer development and progression in order to define improved methods for cancer prevention, detection and therapy. Fisher pioneered a powerful technique to study gene expression in specific tissues or cell types known as subtraction hybridization, which he has used to identify genes involved in many important and medically relevant physiological processes including cancer, neurodegeneration and infectious diseases. Studies in his laboratory focus on understanding the molecular and biochemical reasons for cancer development with a specific focus on understanding how cancers spread, a process called metastasis. The ultimate aim is to use this collected knowledge to bring new, more effective prevention techniques, diagnostic approaches and therapies from the laboratory bench to the patient’s bedside. This is epitomized by his studies involving mda-7/IL-24, a gene that was discovered in his laboratory and has displayed significant clinical efficacy in a phase 1 clinical trial when injected directly into advanced cancers using a form of viral gene therapy. Using a novel cancer terminator virus, Ad.5/3-CTV, that is designed to replicate only within cancer cells while delivering the immune-modulating and toxic mda-7/IL-24 gene, Fisher and his clinical colleagues are developing a clinical trial in patients with glioblastoma multiforme, the most common and deadly form of brain cancer. Fisher has been consistently funded by the National Institutes of Health (NIH) over the past 35 years and is among the top 5 percent of NIH funded investigators during this period. He has published over 500 primary papers and reviews, served on numerous NIH study sections and government and private grant review panels and has over 55 issued patents. He is the recipient of multiple National Cancer Institute (NCI) Program Project Grants; investigator initiated R01 grants from the NIH, NCI and National Institute of General Medical Sciences (NIGMS); private foundation grants from the National Foundation for Cancer Research and the Samuel Waxman Cancer Research Foundation; and an Institutional Research and Academic Career Development Award from the NIH focusing on preparing students from groups underrepresented in the sciences for research careers. Fisher is Professor and Chair of the Department of Human and Molecular Genetics at the Virginia Commonwealth University (VCU) School of Medicine, Founding Director of the VCU Institute of Molecular Medicine and Thelma Newmeyer Corman Chair in Cancer Research and co-leader of the Cancer Molecular Genetics research program at VCU Massey Cancer Center.

Affiliations and Expertise

Professor and Chairman, Dept of Human and Molecular Genetics, Thelma Newmeyer Corman Chair in Cancer Research, Research, Director, VCU Institute of Molecular Medicine, Virginia, USA