Molecular and Cellular Aspects of Muscle Function

Molecular and Cellular Aspects of Muscle Function

Proceedings of the 28th International Congress of Physiological Sciences Budapest 1980, (including the proceedings of the satellite symposium on Membrane Control of Skeletal Muscle Function)

1st Edition - January 1, 1981

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  • Editors: E. Varga, A. Kövér, T. Kovács
  • eBook ISBN: 9781483280707

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Advances in Physiological Sciences, Volume 5: Molecular and Cellular Aspects of Muscle Function covers the proceedings of the 28th International Congress of Physiological Sciences, held in Budapest in 1980 (including the proceedings of the satellite symposium on Membrane Control of Skeletal Muscle Function). The book focuses on the molecular and cellular facets of skeletal muscle function. The selection first offers information on the mechanical properties of cross-bridges and their relation to muscle contraction; molecular basis of functional specialization in muscle as induced by innervation; and electrical properties of crustacean muscle membranes. The text then ponders on contractile protein isoforms in developing muscle; effect of age and exercise on minced gastrocnemius muscle regeneration; and contractile proteins of rat gastrocnemius during its regeneration after mincing. The publication examines the behavior of myosin projections in frog striated muscle during isometric contraction; energetics of contracting muscle and its relation to crossbridge mechanisms; and time course of chemical change and energy production during contraction of frog skeletal muscle. The physiological analysis of human myopathy and adaptation in normal and diseased muscle are also discussed. The selection is a vital source of data for readers interested in the cellular and molecular aspects of muscle function.

Table of Contents

  • Foreword


    The Mechanical Properties of Cross-Bridges and their Relation to Muscle Contraction

    The Molecular Basis of Functional Specialization in Muscle as Induced by the Innervation

    Electrical Properties of Crustacean Muscle Membranes

    Calcium Exchange and Compartmentalization

    Ca2+ Compartments in Vascular Smooth Muscle

    Concluding Remarks on Calcium Exchange and Compartmentalization

    Molecular and Functional Aspects of Muscle Differentiation

    Contractile Protein Isoforms in Developing Muscle: The Nature of the Myosin Isozymes

    The Effect of Age and Exercise on Minced Gastrocnemius Muscle Regeneration

    The Contractile Proteins of Rat Gastrocnemius During its Regeneration After Mincing

    The Role of Serum Proteins in the Differentiation of Skeletal Muscle Tissue in Vitro

    Concluding Remarks on Molecular and Functional Aspects of Muscle Differentiation

    Smooth Muscle

    Mediators and Mechanisms of Activation of Contraction in Smooth Muscle

    The Transport Mechanisms by which Contraction Activating Extracellular Ca2+ Ions Enter Smooth Muscle Cells (Introductory Remarks)

    The Mechanisms of Action of Muscarinic Agonists on the Guinea-Pig Taenia Coli

    The Contribution of Calcium to the Alpha-Action of Catecholamines on the Guinea-Pig Taenia Coli

    Action of Apamin on Nerve-Muscle Transmission and the Effects of ATP and Noradrenaline in Smooth Muscles

    On the Mechanisms Underlying the Relaxation of the Lower Esophageal and Ileocecal Sphincters in the Case of Increased K+

    Relaxation of Tetanized Tracheal Smooth Muscle

    Concluding Remarks on Smooth Muscle

    Cross Bridge Mechanism and Energetics

    Behaviour of Myosin Projections in Frog Striated Muscle During Isometric Contraction

    The Energetics of Contracting Muscle and its Relation to Crossbridge Mechanisms

    Energy Balance-Sheet in Isometric Tetani at 0°C

    Time Course of Chemical Change and Energy Production During Contraction of Frog Skeletal Muscle

    Heat Capacity Changes in Calcium and Magnesium Binding to Troponin

    Data to the Problem of Unexplained Energy Production

    Concluding Remarks on Cross-Bridge Mechanism and Energetics

    Physiological Studies on Muscle Diseases

    Physiological Analysis of Human Myopathy

    Adaptation in Normal and Diseased Muscle

    The Pathophysiology of Regenerating Skeletal Muscle

    Physiological Studies on Myotonia

    Contractile and Chemosensitive Properties of Diseased Muscle

    "Leaky" Membrane Causes Weakness in Dystrophic Soleus Fibers

    Neutral Amino Acid Transport into Skeletal Muscle

    The Effects of Glucocorticoids on the Growth and Protein Turnover of Six Striated Muscles of the Rat

    Effects of Glucocorticoids on Muscle Growth in Young Rats

    Concluding Remarks on Physiological Studies on Muscle Diseases

    Membrane Control of Skeletal Muscle Function

    Satellite Symposium Debrecen

    "Going Through the Usual Channels"

    Cevadine Induced Changes of Na-Channels in Muscle Membrane

    Inward Rectification in Skeletal Muscle Fibers

    The Increase in Potassium Conductance in Metabolically Poisoned Skeletal Muscle Fibers

    Chloride Conductance in Slow and Fast Mammalian Skeletal Muscle Fibers

    Calcium Current in Twitch Muscle Fibers of the Frog

    Ryanodine and the Calcium Channel in Crab Muscle Fibers

    Three-Dimensional Structure of the T-System of Skeletal Muscle Cells

    Ca++ Channels in Muscle Membrane: The Decline of Calcium Current Under Maintained Depolarization

    Asymmetrical Charge Movement in Normal and Glycerol-Treated Toad Sartorius Fibers

    The Role of Ion Movements in the Control of Metabolism in Skeletal Muscle

    Effect of Caffeine on Mechanical Activation in Cut Skeletal Muscle Fibers

    Does Indodicarbocyanine Fluorescence Reflect Membrane Potential of the Sarcoplasmic Reticulum in Skeletal Muscle?

    Birefringence Signal and Latency Relaxation in Frog Skeletal Muscle Fibers

    The Role of External Ca2+ in Excitation-Contraction Coupling

    Surface and Tubular Membrane Sodium Currents in Frog Twitch Muscle Fibre; Implication in Excitation Contraction Coupling

    A Sodium-Induced Calcium Release Mechanism on Frog Muscle Fibers; its Possible Role in the ECC Mechanism

    Transient Kinetics for Ca Uptake by Fragmented Sarcoplasmic Reticulum from Bullfrog Skeletal Muscle with Reference to the Rate of Relaxation of Living Muscle


Product details

  • No. of pages: 454
  • Language: English
  • Copyright: © Pergamon 1981
  • Published: January 1, 1981
  • Imprint: Pergamon
  • eBook ISBN: 9781483280707

About the Editors

E. Varga

A. Kövér

T. Kovács

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