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Molecular and Cell Biology of Pain - 1st Edition - ISBN: 9780128013892, 9780128014325

Molecular and Cell Biology of Pain, Volume 131

1st Edition

Serial Volume Editors: Theodore Price Greg Dussor
Hardcover ISBN: 9780128013892
eBook ISBN: 9780128014325
Imprint: Academic Press
Published Date: 1st March 2015
Page Count: 648
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Table of Contents

    <li>Preface</li> <li>Chapter One: An Introduction to Pain Pathways and Pain &#x201C;Targets&#x201D;<ul><li>Abstract</li><li>1 An Introduction to Pain and Pain Pathways</li><li>2 Ion Channels, Receptors, and Other &#x201C;Targets&#x201D; for Persistent Inflammatory or Neuropathic Pain</li><li>3 Summary</li><li>Acknowledgments</li></ul></li> <li>Chapter Two: Peripheral Scaffolding and Signaling Pathways in Inflammatory Pain<ul><li>Abstract</li><li>1 Introduction</li><li>2 Inflammatory Mediators</li><li>3 Signaling Mechanisms</li><li>4 Scaffolding Structures</li><li>5 Concluding Remarks</li></ul></li> <li>Chapter Three: Contribution of Mechanosensitive Ion Channels to Somatosensation<ul><li>Abstract</li><li>1 The Evolution of Mechanosensing</li><li>2 MSCs in Nociceptors</li><li>3 Difficulties in Identifying Genes Encoding MSCs</li><li>4 Gating Mechanisms of MSCs</li><li>5 Role of MSCs in the Transmission of Noxious Mechanical Inputs</li><li>6 Sensitization of MSCs Is Necessary for the Induction of Mechanical Allodynia</li><li>7 Potassium-Selective MSCs in Nociceptors</li></ul></li> <li>Chapter Four: Sensory TRP Channels: The Key Transducers of Nociception and Pain<ul><li>Abstract</li><li>1 Introduction</li><li>2 Ion Channels in the TRPV Subfamily</li><li>3 Ion Channels in the TRPM Subfamily</li><li>4 Ion Channels in the TRPA Subfamily</li><li>Acknowledgments</li></ul></li> <li>Chapter Five: The Contribution of Mitochondria to Sensory Processing and Pain<ul><li>Abstract</li><li>1 Introduction</li><li>2 Role of Mitochondria in Normal Sensory Processing and Acute Pain</li><li>3 Clinical Evidence of Mitochondrial Dysfunction in Painful Conditions</li><li>4 Preclinical Evidence of Mitochondrial Dysfunction in Chronic Pain States</li><li>5 Future Perspectives</li><li>Acknowledgments</li></ul></li> <li>Chapter Six: Regulation of Gene Expression and Pain States by Epigenetic Mechanisms<ul><li>Abstract</li><li>1 Introduction</li><li>2 Epigenetic Mechanisms and Gene Expression</li><li>3 Epigenetic Regulation of Synaptic Plasticity in Learning and Memory</li><li>4 Epigenetic Mechanisms and Pain States</li><li>5 Future Directions</li><li>Acknowledgments</li></ul></li> <li>Chapter Seven: Translational Control of Chronic Pain<ul><li>Abstract</li><li>1 Introduction</li><li>2 Repair of Injured Tissue</li><li>3 Case for Axonal Translation</li><li>4 Regulation of Protein Synthesis</li><li>5 Transport and Storage of mRNAs</li><li>6 Conclusions and Perspectives</li><li>7 Translational Control of Central Sensitization</li><li>8 Conclusions</li></ul></li> <li>Chapter Eight: MicroRNA Biology and Pain<ul><li>Abstract</li><li>1 Introduction</li><li>2 History and Biogenesis</li><li>3 Genomic Location of miRNAs</li><li>4 miRNA Nomenclature</li><li>5 miRNA Target Determination</li><li>6 miRNA Detection, Quantification, and Functional Studies</li><li>7 Circulating miRNAs</li><li>8 miRNAs and Pain</li><li>9 Challenges Associated with miRNA Research</li><li>10 Conclusions</li><li>Acknowledgments</li></ul></li> <li>Chapter Nine: Role of Extracellular Damage-Associated Molecular Pattern Molecules (DAMPs) as Mediators of Persistent Pain<ul><li>Abstract</li><li>1 Introduction</li><li>2 High-Mobility Group Box 1</li><li>3 S100 Proteins</li><li>4 Heat-Shock Proteins</li><li>5 microRNA</li><li>6 Purine Metabolites</li><li>7 Summary and Perspective</li></ul></li> <li>Chapter Ten: mGluRs Head to Toe in Pain<ul><li>Abstract</li><li>1 Introduction</li><li>2 Metabotropic Receptors</li><li>3 Analysis of mGluRs at Each Level of the Pain Neuraxis</li><li>4 Conclusion</li></ul></li> <li>Chapter Eleven: Nonneuronal Central Mechanisms of Pain: Glia and Immune Response<ul><li>Abstract</li><li>1 Introduction</li><li>2 The Central Multipartite Synapse in the Mechanisms of Chronic Pain</li><li>3 Glial Activation or Reactivity: A Change in Cellular Phenotype in Pain States</li><li>4 Triggers of the Change of Glial Phenotype in Pain States</li><li>5 Drugs with Glial Modulation Capabilities and Efficacy in Preclinical Models of Pain</li><li>6 What It Is Known of Glial Cells in Humans with Pain Conditions?</li><li>7 Glial Cells: Human Versus Rodents and Other Species</li><li>8 Clinical Data Using Glial Modulating Agents</li><li>9 Conclusions</li><li>Acknowledgments</li></ul></li> <li>Chapter Twelve: Synaptic Inhibition and Disinhibition in the Spinal Dorsal Horn<ul><li>Abstract</li><li>1 Introduction</li><li>2 Synthesis and Handling of Inhibitory Neurotransmitters</li><li>3 GABA and Glycine Receptors</li><li>4 Driving Force and Ion Flux</li><li>5 Regulation of Intracellular Anion Concentrations</li><li>6 Mechanisms of Inhibition</li><li>7 Inhibitory Interneurons and Dorsal Horn Circuitry</li><li>8 Pathological Changes in Inhibition</li><li>9 Implications for Therapeutic Interventions</li><li>10 Summary</li></ul></li> <li>Chapter Thirteen: Dendritic Spine Dysgenesis in Neuropathic Pain<ul><li>Abstract</li><li>1 A Brief History</li><li>2 Dendritic Spine Morphology</li><li>3 Dendritic Spines in Synaptic Function</li><li>4 Dendritic Spines in Pathology</li><li>5 Dendritic Spines in Neuropathic Pain</li><li>6 Spinal Cord Injury</li><li>7 Peripheral Nerve Injury</li><li>8 Diabetes Mellitus</li><li>9 Thermal Burn Injury</li><li>10 Molecular Control of Dendritic Spine Dysgenesis</li><li>11 Spinal Memory Mechanism in Neuropathic Pain</li><li>12 Final Perspectives</li></ul></li> <li>Chapter Fourteen: Commonalities Between Pain and Memory Mechanisms and Their Meaning for Understanding Chronic Pain<ul><li>Abstract</li><li>1 Introduction: Pain Plasticity and &#x201C;Pain Memory&#x201D;</li><li>2 The Adaptive Nature of Pain Plasticity</li><li>3 The Peripheral Nociceptor as the Locus of &#x201C;Pain Memory,&#x201D; Focus on Translation Control</li><li>4 &#x201C;Pain Memory&#x201D; in the Spinal Dorsal Horn</li><li>5 Clinical Implications of Pain Memory</li><li>6 Conclusions</li><li>Acknowledgments</li></ul></li> <li>Chapter Fifteen: Dietary Influence on Pain via the Immune System<ul><li>Abstract</li><li>1 Cytokines and Immunity</li><li>2 Cytokines and Chronic Pain</li><li>3 Obesity and Pain</li><li>4 Diet and Inflammation</li><li>5 Omega-3 and Omega-6 PUFAs</li><li>6 Saturated Fats</li><li>7 Grape Seed Extract</li><li>8 Green Tea Extract</li><li>9 Soy Products</li><li>10 Broccoli</li><li>11 Carotenoids</li><li>12 Ginger</li><li>13 Ginseng</li><li>14 Caffeine</li><li>15 Grains and Gluten</li><li>16 Ketogenic Diets</li><li>17 Dietary Interventions</li><li>18 Conclusions</li></ul></li> <li>Chapter Sixteen: Chemotherapy-Induced Peripheral Neuropathy<ul><li>Abstract</li><li>1 Chemotherapy-Induced Neuropathy: An Introduction</li><li>2 Classes of Chemotherapeutics</li><li>3 Clinical Assessment of CIPN</li><li>4 Experimental Studies: Animal Models of CIPN</li><li>5 Experimental Studies: <i>In Vitro</i> Models of CIPN</li><li>6 Proposed Mechanisms Underlying CIPN</li><li>7 Challenges to CIPN Research</li></ul></li> <li>Chapter Seventeen: Stress and Chronic Pelvic Pain<ul><li>Abstract</li><li>1 Introduction</li><li>2 Central and Peripheral Regulation of the Stress Pathway</li><li>3 Consequences of Early Life Stress</li><li>4 Irritable Bowel Syndrome</li><li>5 Interstitial Cystitis/Painful Bladder Syndrome</li><li>6 Vulvodynia</li><li>7 Chronic Prostatitis/Chronic Pelvic Pain Syndrome</li><li>8 Conclusions</li></ul></li> <li>Chapter Eighteen: Meningeal Afferent Signaling and the Pathophysiology of Migraine<ul><li>Abstract</li><li>1 Introduction</li><li>2 Features of Migraine</li><li>3 Current Migraine Treatments</li><li>4 Anatomy of the Meningeal Afferent System</li><li>5 Migraine Pathophysiology</li><li>6 Potential Mechanisms of Dural Afferent Activation</li><li>7 Ion Channels and Dural Afferent Activation</li><li>8 Dural Afferent Input May Lead to Neuroplasticity</li><li>9 Neuroplasticity and Migraine</li><li>10 CGRP and Migraine Plasticity</li><li>11 BDNF and Migraine</li><li>12 Conclusion</li><li>Acknowledgments</li></ul></li> <li>Chapter Nineteen: Chronic Pain Syndromes, Mechanisms, and Current Treatments<ul><li>Abstract</li><li>1 Cancer Pain</li><li>2 Central Poststroke Pain</li><li>3 Chronic Pelvic Pain</li><li>4 Complex Regional Pain Syndrome</li><li>5 Failed Back Syndrome</li><li>6 Fibromyalgia</li><li>7 Irritable Bowel Syndrome</li><li>8 Migraine</li><li>9 Multiple Sclerosis</li><li>10 Peripheral Neuropathic Pain</li><li>11 Persistent Postsurgical Pain</li><li>12 Phantom Limb Pain</li><li>13 Postherpetic Neuralgia</li><li>14 Rheumatoid Arthritis</li><li>15 Trigeminal Neuralgia</li><li>16 Future Directions</li></ul></li> <li>Index</li>


Pain is the number one reason that people seek medical attention but pain is still under- and poorly-treated world-wide. The purpose of this book is to give an up to date picture of what causes pain, how pain becomes chronic and what pharmacological targets might be manipulated to alleviate acute and chronic pain. The book will cover a wide array of topics from gene polymorphisms to voltage-gated ion channels moving from cellular biology to whole animal physiology.

Key Features

  • Written by future leaders in the pain field
  • Covers a wide range of targets
  • Contains provocative ideas about the future direction of the pain field.


Students, researchers, microbiologists, molecular biologists


No. of pages:
© Academic Press 2015
1st March 2015
Academic Press
Hardcover ISBN:
eBook ISBN:

Ratings and Reviews

About the Serial Volume Editors

Theodore Price

Affiliations and Expertise

University of Texas at Dallas, Richardson, TX, USA

Greg Dussor

Affiliations and Expertise

The University of Texas at Dallas, Richardson, TX, USA