Modifications of Nuclear DNA and its Regulatory Proteins

Modifications of Nuclear DNA and its Regulatory Proteins

1st Edition - April 27, 2011

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  • Editors: Xiaodong Cheng, Robert Blumenthal
  • eBook ISBN: 9780123876867
  • Hardcover ISBN: 9780123876850

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Description

DNA methylation is essential for the normal development and functioning of organisms. This volume discusses the latest developments in this very active field of research. It presents the evolution of DNA methylation, mammalian DNA methyltransferases, DNA methylation and demethlyation, DNA methylation and silencing and the role it plays in medicine including cancer.

Key Features

  • Discusses new discoveries, approaches, and ideas
  • Contributions from leading scholars and industry experts
  • Reference guide for researchers involved in molecular biology and related fields

Readership

Researchers, professors and graduate students in biochemistry, chemistry, molecular biology, biotechnology, and medicine.

Table of Contents

  • 1. Introduction – Epiphanies in Epigenetics
    Xiaodong Cheng and Robert M. Blumenthal

    Section I. EVOLUTION OF DNA METHYLATION
    2. The natural history of eukaryotic DNA methylation systems
    Lakshminarayan M. Iyer, Saraswathi Abhiman, L. Aravind
    3. Evolution of histone methyltransferases and demethylases
    L. Aravind
    4. DNA methylation in Drosophila – A critical evaluation
    Veiko Krauss and Gunter Reuter
    5. DNA Methylation in Zebrafish
    Mary G Goll and Marnie E Halpern

    Seciton II. MAMMALIAN DNA METHYLTRANSFERASES – STRUCTURE AND FUNCTION
    6. Dnmt1 - structure and function
    Željko M. Svedružić
    7. The DNMT3 family of MAMMALIAN de novo DNA methyltransferases
    Frédéric Chédin

    Seciton III. DNA METHYLATION AND DEMETHYLATION
    8. Recruitment of Dnmt1: Roles of the SRA protein Np95 (Uhrf1) and other factors
    Jafar Sharif & Haruhiko Koseki
    9. Regulation of Expression and Activity of DNA (cytosine-5) methyltransferases in mammalian cells
    Shannon R. Morey Kinney and Sriharsa Pradhan
    10. Mechanistic and functional links between histone methylation and DNA methylation
    Taiping Chen

    Section IV. DNA METHYLATION IN MEDICINE
    11. RNA mediated silencing mechanisms in mammalian cells
    Anton Wutz
    12. Biological functions of methyl-CpG binding proteins
    Pierre-Antoine Defossez and Irina Stancheva

    Section V. DNA METHYLATION IN MEDICINE
    13. Diseases associated with imprinting
    J.F. Wilkins and F. Úbeda
    14. DNA methylation changes in cancer
    Minoru Toyota and Eiichiro Yamamoto
    15. Epigenetic biomarkers
    J. Tost
    16. Distribution of methylation at the single-nucleotide level
    E. Wong

Product details

  • No. of pages: 502
  • Language: English
  • Copyright: © Academic Press 2011
  • Published: April 27, 2011
  • Imprint: Academic Press
  • eBook ISBN: 9780123876867
  • Hardcover ISBN: 9780123876850

About the Serial Volume Editors

Xiaodong Cheng

Affiliations and Expertise

Emory University School of Medicine, Atlanta, GA, USA

Robert Blumenthal

Affiliations and Expertise

The University of Toledo College of Medicine, OH, USA

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