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Modifications of Nuclear DNA and its Regulatory Proteins - 1st Edition - ISBN: 9780123876850, 9780123876867

Modifications of Nuclear DNA and its Regulatory Proteins, Volume 101

1st Edition

Serial Volume Editors: Xiaodong Cheng Robert Blumenthal
Hardcover ISBN: 9780123876850
eBook ISBN: 9780123876867
Imprint: Academic Press
Published Date: 27th April 2011
Page Count: 502
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Table of Contents

1. Introduction – Epiphanies in Epigenetics
Xiaodong Cheng and Robert M. Blumenthal

Section I. EVOLUTION OF DNA METHYLATION
2. The natural history of eukaryotic DNA methylation systems
Lakshminarayan M. Iyer, Saraswathi Abhiman, L. Aravind
3. Evolution of histone methyltransferases and demethylases
L. Aravind
4. DNA methylation in Drosophila – A critical evaluation
Veiko Krauss and Gunter Reuter
5. DNA Methylation in Zebrafish
Mary G Goll and Marnie E Halpern

Seciton II. MAMMALIAN DNA METHYLTRANSFERASES – STRUCTURE AND FUNCTION
6. Dnmt1 - structure and function
Željko M. Svedružić
7. The DNMT3 family of MAMMALIAN de novo DNA methyltransferases
Frédéric Chédin

Seciton III. DNA METHYLATION AND DEMETHYLATION
8. Recruitment of Dnmt1: Roles of the SRA protein Np95 (Uhrf1) and other factors
Jafar Sharif & Haruhiko Koseki
9. Regulation of Expression and Activity of DNA (cytosine-5) methyltransferases in mammalian cells
Shannon R. Morey Kinney and Sriharsa Pradhan
10. Mechanistic and functional links between histone methylation and DNA methylation
Taiping Chen

Section IV. DNA METHYLATION IN MEDICINE
11. RNA mediated silencing mechanisms in mammalian cells
Anton Wutz
12. Biological functions of methyl-CpG binding proteins
Pierre-Antoine Defossez and Irina Stancheva

Section V. DNA METHYLATION IN MEDICINE
13. Diseases associated with imprinting
J.F. Wilkins and F. Úbeda
14. DNA methylation changes in cancer
Minoru Toyota and Eiichiro Yamamoto
15. Epigenetic biomarkers
J. Tost
16. Distribution of methylation at the single-nucleotide level
E. Wong


Description

DNA methylation is essential for the normal development and functioning of organisms. This volume discusses the latest developments in this very active field of research. It presents the evolution of DNA methylation, mammalian DNA methyltransferases, DNA methylation and demethlyation, DNA methylation and silencing and the role it plays in medicine including cancer.

Key Features

  • Discusses new discoveries, approaches, and ideas
  • Contributions from leading scholars and industry experts
  • Reference guide for researchers involved in molecular biology and related fields

Readership

Researchers, professors and graduate students in biochemistry, chemistry, molecular biology, biotechnology, and medicine.


Details

No. of pages:
502
Language:
English
Copyright:
© Academic Press 2011
Published:
27th April 2011
Imprint:
Academic Press
Hardcover ISBN:
9780123876850
eBook ISBN:
9780123876867

Reviews

PRAISE FOR THE SERIES
"Full of interest not only for the molecular biologist--for whom the numerous references will be invaluable--but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell."--British Medical Journal

Ratings and Reviews


About the Serial Volume Editors

Xiaodong Cheng

Affiliations and Expertise

Emory University School of Medicine, Atlanta, GA, USA

Robert Blumenthal

Affiliations and Expertise

The University of Toledo College of Medicine, OH, USA