Description

DNA methylation is essential for the normal development and functioning of organisms. This volume discusses the latest developments in this very active field of research. It presents the evolution of DNA methylation, mammalian DNA methyltransferases, DNA methylation and demethlyation, DNA methylation and silencing and the role it plays in medicine including cancer.

Key Features

* Discusses new discoveries, approaches, and ideas
* Contributions from leading scholars and industry experts
* Reference guide for researchers involved in molecular biology and related fields

Readership

Researchers, professors and graduate students in biochemistry, chemistry, molecular biology, biotechnology, and medicine.

Table of Contents

  1. Introduction – Epiphanies in Epigenetics
    Xiaodong Cheng and Robert M. Blumenthal
  2. Section I. EVOLUTION OF DNA METHYLATION

  3. The natural history of eukaryotic DNA methylation systems
    Lakshminarayan M. Iyer, Saraswathi Abhiman, L. Aravind
  4. Evolution of histone methyltransferases and demethylases
    L. Aravind
  5. DNA methylation in Drosophila – A critical evaluation
    Veiko Krauss and Gunter Reuter
  6. DNA Methylation in Zebrafish
    Mary G Goll and Marnie E Halpern
  7. Seciton II. MAMMALIAN DNA METHYLTRANSFERASES – STRUCTURE AND FUNCTION

  8. Dnmt1 - structure and function
    Željko M. Svedružić
  9. The DNMT3 family of MAMMALIAN de novo DNA methyltransferases
    Frédéric Chédin
  10. Seciton III. DNA METHYLATION AND DEMETHYLATION

  11. Recruitment of Dnmt1: Roles of the SRA protein Np95 (Uhrf1) and other factors
    Jafar Sharif & Haruhiko Koseki
  12. Regulation of Expression and Activity of DNA (cytosine-5) methyltransferases in mammalian cells
    Shannon R. Morey Kinney and Sriharsa Pradhan
  13. Mechanistic and functional links between histone methylation and DNA methylation
    Taiping Chen
  14. Section IV. DNA METHYLATION IN MEDICINE

  15. RNA mediated silencing mechanisms in mammalian cells
    Anton Wutz
  16. Biological functions of methyl-CpG binding proteins
    Pierre-Antoine Defossez and Irina Stancheva
  17. Section V. DNA METHYLATION IN MEDICINE

  18. Diseases associated with imprinting
    J.F. Wilkins and F. Úbeda
  19. DNA methylation changes in cancer
    Minoru Toyota and Eiichiro Yamamoto
  20. Epigenetic biomarkers
    J. Tost
  21. Distribution of methylation at the single-nucleotide level
    E. Wong

Details

No. of pages:
502
Language:
English
Copyright:
© 2011
Published:
Imprint:
Academic Press
eBook ISBN:
9780123876867
Print ISBN:
9780123876850

About the serial-volume-editors

Xiaodong Cheng

Affiliations and Expertise

Emory University School of Medicine, Atlanta, GA, USA

Robert Blumenthal

Affiliations and Expertise

The University of Toledo College of Medicine, OH, USA

Reviews

PRAISE FOR THE SERIES
"Full of interest not only for the molecular biologist--for whom the numerous references will be invaluable--but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell."--British Medical Journal