Modification of Lipid Metabolism

Modification of Lipid Metabolism

1st Edition - January 1, 1975

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  • Editor: Edward G. Perkins
  • eBook ISBN: 9780323158527

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Description

Modification of Lipid Metabolism is a collection of proceedings presented at the Symposium on Modification of Lipid Metabolism, held during the American Chemical Society meeting in Atlantic City, New Jersey, on September 10-11, 1974. The symposium provided a forum for discussing advances in the modification of lipid metabolism and tackled topics ranging from the effect of dietary rapeseed oil on cardiac tissue to inborn errors of lipid metabolism and lysosomal storage disorders. Comprised of 10 chapters, this book begins with an overview of advances in the composition, structure, and functions of lipids in metabolic pathways, followed by a discussion on the effect of dietary rapeseed oil on cardiac tissue. The reader is then introduced to genetic lipid storage diseases, along with their diagnosis and treatment. Viral modification of cell surface glycosphingolipids as an important factor in contact inhibition of cell growth and division is also examined. Subsequent chapters deal with different approaches to the problem of obesity, dietary regulation of lipid storage and the use of a metabolic inhibitor to reduce lipid storage; the importance of perinatal nutrition; factors in the environment that may effect tissue lipids and their metabolism; and phase transitions in membranes and the effect of temperature changes on changes in lipids and proteins of membranes. This monograph should be of interest to practitioners in the fields of biology, biochemistry, and food science and nutrition.

Table of Contents


  • List of Contributors

    Preface

    Recent Developments in Lipid Biosynthetic Pathways

    I. Introduction

    II. Phospholipids

    III. Sphingomyelin

    IV. Bacterial Pathways

    V. Glyceryl Ethers

    VI. Glycolipids

    VII. Small Glycolipids

    VIII. Complex Carbohydrates Containing Lipid

    IX. Polyisoprenols

    X. Fatty Acids

    XI. Unsaturated Fatty Acid Biosynthesis

    XII. Fatty Acid Elongation and Hydroxylation

    XIII. Vitamin Ε

    References

    The Effect of Dietary Rapeseed Oil on Cardiac Tissue

    I. Introduction

    II. Early Lipidosis

    III. Fate of Erucic Acid

    IV. Necrosis and Fibrosis

    References

    Inborn Errors of Lipid Metabolism and Lysosomal Storage Disorders

    I. Introduction

    II. Lysosomes and Cellular Turnover

    III. Primary Lysosomal Disorders

    IV. Secondary Lysosomal Disorders

    V. Diagnosis

    VI. Treatment of Lysosomal Disorders

    Summary

    Acknowledgments

    References

    Intervention in Sphingolipid Metabolism with Synthetic Inhibitors

    I. Text

    Summary

    References

    Modification of Membrane Glycolipids by Oncogenic Agents

    I. Introduction

    II. Ganglioside Metabolism in Normal and Transformed Mouse Cells

    III. Modulation of Transformation and Ganglioside Biosynthesis

    IV. Molecular Basis for Altered Ganglioside Biosynthesis

    Summary

    References

    Dietary Regulation of Lipid Metabolism

    I. Introduction

    II. Dietary Fat

    III. Dietary Protein

    IV. Dietary Carbohydrate and Meal Pattern

    V. Dietary Butanediol

    VI. Conclusions

    Acknowledgments

    References

    Effect of (-)-Hydroxycitrate on Lipid Metabolism

    I. Introduction

    II. Stereoisomers of Hydroxycitrate

    III. Effects on Lipid Biosynthesis

    IV. Effects of (-)-Hydroxycitrate on Lipid Accumulation

    Summary

    Acknowledgments

    References

    Early Nutritional Influences on Development

    I. Introduction

    II. Human Studies: Adipose Cellularity and Weight Reduction

    III. Animal Studies: Normal Development

    IV. Animal Studies: 3Η-Thymidine In Vivo Injections

    V. Animal Studies: Genetically Obese Zucker Rats

    VI. Brain Development: Normal Growth

    VII. Brain Development: Effect of Early Malnutrition 191

    Summary

    Acknowledgments

    References

    The Influence of Environmental Factors on Lipid Metabolism

    I. Text

    References

    The Effect of Temperature Changes on Lipids and Proteins of Biological Membranes

    Summary

    I. Introduction

    II. Liquid to Solid Phase Transitions

    III. Freeze-Fracture Electron Microscopy and Phase Transitions

    IV. Alteration of Phase Transitions

    V. Critical Viscosity or Critical Volume Transition

    VI. Role of Cholesterol in Lipid Phase Transitions of Animal Cell Membranes

    VII. Protein Conformational Changes

    VIII. Cold Adaptation and Hibernation

    Acknowledgments

    References

    Subject Index

Product details

  • No. of pages: 268
  • Language: English
  • Copyright: © Academic Press 1975
  • Published: January 1, 1975
  • Imprint: Academic Press
  • eBook ISBN: 9780323158527

About the Editor

Edward G. Perkins

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