Modification of Lipid Metabolism - 1st Edition - ISBN: 9780125511506, 9780323158527

Modification of Lipid Metabolism

1st Edition

eBook ISBN: 9780323158527
Imprint: Academic Press
Published Date: 1st January 1975
Page Count: 268
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Modification of Lipid Metabolism is a collection of proceedings presented at the Symposium on Modification of Lipid Metabolism, held during the American Chemical Society meeting in Atlantic City, New Jersey, on September 10-11, 1974. The symposium provided a forum for discussing advances in the modification of lipid metabolism and tackled topics ranging from the effect of dietary rapeseed oil on cardiac tissue to inborn errors of lipid metabolism and lysosomal storage disorders.

Comprised of 10 chapters, this book begins with an overview of advances in the composition, structure, and functions of lipids in metabolic pathways, followed by a discussion on the effect of dietary rapeseed oil on cardiac tissue. The reader is then introduced to genetic lipid storage diseases, along with their diagnosis and treatment. Viral modification of cell surface glycosphingolipids as an important factor in contact inhibition of cell growth and division is also examined. Subsequent chapters deal with different approaches to the problem of obesity, dietary regulation of lipid storage and the use of a metabolic inhibitor to reduce lipid storage; the importance of perinatal nutrition; factors in the environment that may effect tissue lipids and their metabolism; and phase transitions in membranes and the effect of temperature changes on changes in lipids and proteins of membranes.

This monograph should be of interest to practitioners in the fields of biology, biochemistry, and food science and nutrition.

Table of Contents

List of Contributors


Recent Developments in Lipid Biosynthetic Pathways

I. Introduction

II. Phospholipids

III. Sphingomyelin

IV. Bacterial Pathways

V. Glyceryl Ethers

VI. Glycolipids

VII. Small Glycolipids

VIII. Complex Carbohydrates Containing Lipid

IX. Polyisoprenols

X. Fatty Acids

XI. Unsaturated Fatty Acid Biosynthesis

XII. Fatty Acid Elongation and Hydroxylation

XIII. Vitamin Ε


The Effect of Dietary Rapeseed Oil on Cardiac Tissue

I. Introduction

II. Early Lipidosis

III. Fate of Erucic Acid

IV. Necrosis and Fibrosis


Inborn Errors of Lipid Metabolism and Lysosomal Storage Disorders

I. Introduction

II. Lysosomes and Cellular Turnover

III. Primary Lysosomal Disorders

IV. Secondary Lysosomal Disorders

V. Diagnosis

VI. Treatment of Lysosomal Disorders




Intervention in Sphingolipid Metabolism with Synthetic Inhibitors

I. Text



Modification of Membrane Glycolipids by Oncogenic Agents

I. Introduction

II. Ganglioside Metabolism in Normal and Transformed Mouse Cells

III. Modulation of Transformation and Ganglioside Biosynthesis

IV. Molecular Basis for Altered Ganglioside Biosynthesis



Dietary Regulation of Lipid Metabolism

I. Introduction

II. Dietary Fat

III. Dietary Protein

IV. Dietary Carbohydrate and Meal Pattern

V. Dietary Butanediol

VI. Conclusions



Effect of (-)-Hydroxycitrate on Lipid Metabolism

I. Introduction

II. Stereoisomers of Hydroxycitrate

III. Effects on Lipid Biosynthesis

IV. Effects of (-)-Hydroxycitrate on Lipid Accumulation




Early Nutritional Influences on Development

I. Introduction

II. Human Studies: Adipose Cellularity and Weight Reduction

III. Animal Studies: Normal Development

IV. Animal Studies: 3Η-Thymidine In Vivo Injections

V. Animal Studies: Genetically Obese Zucker Rats

VI. Brain Development: Normal Growth

VII. Brain Development: Effect of Early Malnutrition 191




The Influence of Environmental Factors on Lipid Metabolism

I. Text


The Effect of Temperature Changes on Lipids and Proteins of Biological Membranes


I. Introduction

II. Liquid to Solid Phase Transitions

III. Freeze-Fracture Electron Microscopy and Phase Transitions

IV. Alteration of Phase Transitions

V. Critical Viscosity or Critical Volume Transition

VI. Role of Cholesterol in Lipid Phase Transitions of Animal Cell Membranes

VII. Protein Conformational Changes

VIII. Cold Adaptation and Hibernation



Subject Index


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© Academic Press 1975
Academic Press
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