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Modern Concepts of Focal Epileptic Networks - 1st Edition - ISBN: 9780124186934, 9780124199576

Modern Concepts of Focal Epileptic Networks, Volume 114

1st Edition

Serial Volume Editors: Premysl Jiruska Marco De Curtis John Jefferys
Hardcover ISBN: 9780124186934
eBook ISBN: 9780124199576
Imprint: Academic Press
Published Date: 23rd July 2014
Page Count: 364
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Table of Contents

  • Chapter One: Modern Concepts of Focal Epileptic Networks
    • Acknowledgments
  • Chapter Two: Neocortical Focus: Experimental View
    • Abstract
    • 1 Introduction
    • 2 Neocortical Neuronal Activities During States of Vigilance
    • 3 Neocortical Neuronal Activities During Seizures
    • 4 Alterations of Synaptic and Intrinsic Excitability During Seizures
    • 5 Unbalance of Excitatory and Inhibitory Influences Leading to Seizure Generation
    • 6 Focus of Epilepsy Versus Seizure and Interaction of Epileptic Focus with Intact Cortex
    • 7 Neuronal Plasticity Leading to Development of Epilepsy
    • 8 Conclusions
    • Acknowledgments
  • Chapter Three: Malformations of Cortical Development and Neocortical Focus
    • Abstract
    • 1 Introduction
    • 2 Normal and Abnormal Development of the Cerebral Cortex
    • 3 The (Un)identified Neocortical Focus
    • 4 Removal of a Neocortical Focus
    • 5 Conclusion
    • Acknowledgments
  • Chapter Four: Limbic Networks and Epileptiform Synchronization: The View from the Experimental Side
    • Abstract
    • 1 Background
    • 2 Mechanisms Underlying Epileptiform Synchronization
    • 3 Interactions Between Limbic Areas
    • 4 Seizure-Onset Types
    • 5 Modulation of Epileptiform Synchronization by Neurosteroids
    • 6 Conclusions
    • Acknowledgments
  • Chapter Five: Limbic Networks: Clinical Perspective
    • Abstract
    • 1 Introduction
    • 2 Clinical Features of Limbic Epilepsy
    • 3 Structural Networks in Limbic Epilepsy
    • 4 Functional Networks in Limbic Epilepsy
    • 5 Metabolic Networks in Limbic Epilepsy
    • 6 Conclusions
  • Chapter Six: Modern Concepts of Seizure Modeling
    • Abstract
    • 1 Introduction
    • 2 Detailed Biophysical Models
    • 3 Lumped Models
    • 4 Analogies
    • 5 Discussion
    • Acknowledgments
  • Chapter Seven: Mechanisms of Ictogenesis
    • Abstract
    • 1 Introduction
    • 2 Recording the Brain and its Networks During the Transition to Seizures
    • 3 Cellular Substrates of Ictogenesis: Neurons and Neurotransmission
    • 4 The Environment of Neurons: Ions, Astrocytes, and the Extracellular Space
    • 5 Conclusion
    • Acknowledgments
  • Chapter Eight: Seizure Termination
    • Abstract
    • 1 Introduction
    • 2 Metabolic Mechanisms of Seizure Termination
    • 3 Network Aspects of Seizure Termination
    • 4 Conclusions
  • Chapter Nine: Epileptic Focus and Alteration of Metabolism
    • Abstract
    • 1 Introduction
    • 2 Acute Changes in Energy Metabolism During Seizures
    • 3 Metabolic Dysfunction of Chronic Epileptic Tissue
    • 4 Alteration of Mitochondrial Genome in Chronic Epileptic Tissue
    • 5 Changes in Blood Flow Regulation in Epileptic Tissue
    • 6 Alteration of Blood Brain Barrier
    • 7 Conclusions
    • Acknowledgments
  • Chapter Ten: Modern Techniques of Epileptic Focus Localization
    • Abstract
    • 1 Introduction
    • 2 Structural Imaging, Volumetrics, and Morphometric Analysis
    • 3 Functional Neuroimaging in Epilepsies Using PET
    • 4 Ictal Perfusion
    • 5 Irritative Zone as Assessed by BOLD fMRI
    • 6 Conclusions
    • Acknowledgments
  • Chapter Eleven: From Treatment to Cure: Stopping Seizures, Preventing Seizures, and Reducing Brain Propensity to Seize
    • Abstract
    • 1 From Anticonvulsant Therapy to Disease-Modifying Treatment
    • 2 Seizure Prevention: Toward Personalized Medicine to Stop Seizures from Happening
    • 3 Seizure Prevention: Stopping Epileptogenesis
    • 4 Reducing Potential Adverse Effects by Treating Seizures in Real Time
    • 5 Real-Time Seizure Treatments: What to Deliver?
    • 6 Optogenetics
    • 7 Chemical Genetics
    • 8 What to Hit: Are Interneurons a Good Target for Interventions?
    • 9 Gene Therapy: Introducing Genes to Selected Neurons
    • 10 Treatments to Restore Excitability: Is there a Possibility of a Cure?
    • 11 How Far to Cure(s)?
    • Acknowledgments
  • Index
  • Contents of Recent Volumes


This volume of International Review of Neurobiology concentrates on modern concepts of focal epileptic networks. The volume addresses specific topics such as seizures (including transition and termination), limbic networks, alteration of metabolism, and neocortical focus and malformation of cortical development, among others.

Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews, and thematic volumes that focus on recent progress in a specific area of neurobiology research.

Key Features

  • Our knowledge about the mechanisms involved in pathophysiology of epilepsy has rapidly expanded during last decade
  • This special volume brings overview about modern concepts of epileptic focus organization and about the altered neural network dynamics which results in propensity of the brain tissue to generate spontaneous and repeated seizures


Clinical and experimental epileptologists, neuroscientists, mathematicians and physicists interested in complex network dynamics


No. of pages:
© Academic Press 2014
23rd July 2014
Academic Press
Hardcover ISBN:
eBook ISBN:

Ratings and Reviews

About the Serial Volume Editors

Premysl Jiruska

Premysl Jiruska

Dr. Premysl Jiruska is Associate Professor at the Institute of Physiology, Academy of Sciences of Czech Republic. He received his M.D. and Ph.D. degrees from Charles University in Prague Czech Republic. fter completing his PhD, he undertook a postdoctoral position in the group of Prof. John Jefferys at the University of Birmingham, focusing on experimental epilepsy research. In 2008 he was awarded a personal Sir Desmond Pond fellowship by Epilepsy Research UK to conduct independent research on the mechanisms involved in the transition from normal brain activity to seizure. Currently, in his research he focuses on mechanisms of ictogenesis and network organization and dynamics of epileptic foci.

Affiliations and Expertise

Academy of Sciences of Czech Republic, Czech Republic

Marco De Curtis

Marco De Curtis

Marco de Curtis is Head of the Epilepsy Unit and of the Pre-clinical Neuroscience Laboratories at Fondazione Istituto Neurologico Carlo Besta in Milano, Italy. He is interested in function of neuronal networks in health and disease, with particular focus on epilepsy and ictogenesis

Affiliations and Expertise

Fondazione Istituto Neurologico, Milan, Italy

John Jefferys

John Jefferys

John G. R. Jefferys was until recently Professor of Neuroscience at the University of Birmingham, moving to the University of Oxford during the final stages of production of this volume. He received his BSc and PhD in Physiology from University College London and is a Fellow of the Academy of Medical Sciences. His research focuses on the emergent properties of neuronal networks and on the fundamental pathophysiology of focal epilepsy.

Affiliations and Expertise

Univeristy of Oxford, UK