Models of Seizures and Epilepsy

1st Edition

Print ISBN: 9780120885541
eBook ISBN: 9780080457024
Imprint: Academic Press
Published Date: 30th August 2005
Page Count: 712
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An understanding of mechanisms underlying seizure disorders depends critically on the insights provided by model systems. In particular with the development of cellular, molecular, and genetic investigative tools, there has been an explosion of basic epilepsy research. Models of Seizures and Epilepsy brings together, for the first time in 30 years, an overview of the most widely-used models of seizures and epilepsy. Chapters cover a broad range of experimental approaches (from in vitro to whole animal preparations), a variety of epileptiform phenomenology (including burst discharges and seizures), and suggestions for model characterization and validation, such as electrographic, morphologic, pharmacologic, and behavioral features. Experts in the field provide not only technical reviews of these models but also conceptual critiques - commenting on the strengths and limitations of these models, their relationship to clinical phenomenology, and their value in developing a better understanding and treatments. Models of Seizures and Epilepsy is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models for addressing key questions in the field. It also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research.

Table of Contents

Contributing Authors Foreword Preface

  1. What Should Be Modeled? A. In Vitro Preparations
    1. Single Nerve Cells Acutely Dissociated from Animal and Human Brains for Studies of Epilepsy
    2. Cell Culture Models for Studying Epilepsy
    3. An Overview of In Vitro Seizure Models in Acute and Organotypic Slices
    4. The Use of Brain Slice Cultures for the Study of Epilepsy
    5. Hippocampal Slices: Designing and Interpreting Studies in Epilepsy Research
    6. Thalamic, Thalamocortical and Corticocortical Models of Epilepsy with an Emphasis on Absence Seizures
    7. Studying Epilepsy in the Human Brain In Vitro
    8. In Vitro Isolated Guinea Pig Brain B. Induced Seizures in Intact Animals
    9. Pharmacologic Models of Generalized Absence Seizures in Rodents
    10. Models of Chemically-Induced Acute Seizures
    11. Electrical Stimulation-Induced Models of Seizures
    12. Alcohol Withdrawal Seizures
    13. Alumina Gel Injection Models of Epilepsy in Monkeys C. Genetic Models
    14. Modeling Epilepsy and Seizures in Developing Zebrafish Larvae
    15. Transgenic and Gene Replacement Models of Epilepsy: Targeting Ion Channel and Neurotransmission Pathways in Mice
    16. Spontaneous Epileptic Mutations in the Mouse
    17. Genetic Models of Absence Epilepsy in the Rat
    18. Models with Spontaneous Seizures and Developmental Disruption of Genetic Etiology
    19. Mammalian Models of Genetic Epilepsy Characterized by Sensory-Evoked Seizures and Generalized Seizure Susceptibility
    20. Inherited Epilepsy in Mongolian Gerbils D. Acquired Focal Models
    21. The Cortical Freeze Lesion Model
    22. MAM and Other “Lesion” Models of Developmental Epilepsy
    23. In Utero Irradiation as a Model of Cortical Dysplasia
    24. Modeling Hypoxia-Induced Seizures and Hypoxic Encephalopathy in the Neonatal Period
    25. Complex Febrile Seizures—An Experimental Model in Immature Rodents
    26. Repetitive


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"This book is an invaluable resource for those interested in the details of epilepsy. It will be an excellent resource for all neurologists and neurosurgeons involved in research or clinical treatment for the disease." --NEUROSURGERY QUATERLY (Mar-May 2006) "5 Stars - This is a superb and current compendium of selected models of epilepsy and their utility in investigating the various mechanisms and manifestations of epilepsy. ...This book should be on the shelf as a resource for all investigators of the mechanisms of epilepsy whether they utilize cells, slices, mice, humans, or machines. It fills an important void in the review literature that has not been comprehensively addressed for some time." --Gregory Kent Bergery, Johns Hopkins University School of Medicine, in DOODY'S (May 2006)