Models of Seizures and Epilepsy

1st Edition

Editors: Asla Pitkänen Asla Pitkänen Philip Schwartzkroin Solomon Moshé
Hardcover ISBN: 9780120885541
eBook ISBN: 9780080457024
Imprint: Academic Press
Published Date: 30th August 2005
Page Count: 712
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Table of Contents

Contributing Authors Foreword Preface 1. What Should Be Modeled? A. In Vitro Preparations 2. Single Nerve Cells Acutely Dissociated from Animal and Human Brains for Studies of Epilepsy 3. Cell Culture Models for Studying Epilepsy 4. An Overview of In Vitro Seizure Models in Acute and Organotypic Slices 5. The Use of Brain Slice Cultures for the Study of Epilepsy 6. Hippocampal Slices: Designing and Interpreting Studies in Epilepsy Research 7. Thalamic, Thalamocortical and Corticocortical Models of Epilepsy with an Emphasis on Absence Seizures 8. Studying Epilepsy in the Human Brain In Vitro 9. In Vitro Isolated Guinea Pig Brain B. Induced Seizures in Intact Animals 10. Pharmacologic Models of Generalized Absence Seizures in Rodents 11. Models of Chemically-Induced Acute Seizures 12. Electrical Stimulation-Induced Models of Seizures 13. Alcohol Withdrawal Seizures 14. Alumina Gel Injection Models of Epilepsy in Monkeys C. Genetic Models 15. Modeling Epilepsy and Seizures in Developing Zebrafish Larvae 16. Transgenic and Gene Replacement Models of Epilepsy: Targeting Ion Channel and Neurotransmission Pathways in Mice 17. Spontaneous Epileptic Mutations in the Mouse 18. Genetic Models of Absence Epilepsy in the Rat 19. Models with Spontaneous Seizures and Developmental Disruption of Genetic Etiology 20. Mammalian Models of Genetic Epilepsy Characterized by Sensory-Evoked Seizures and Generalized Seizure Susceptibility 21. Inherited Epilepsy in Mongolian Gerbils D. Acquired Focal Models 22. The Cortical Freeze Lesion Model 23. MAM and Other “Lesion” Models of Developmental Epilepsy 24. In Utero Irradiation as a Model of Cortical Dysplasia 25. Modeling Hypoxia-Induced Seizures and Hypoxic Encephalopathy in the Neonatal Period 26. Complex Febrile Seizures—An Experimental Model in Immature Rodents 27. Repetitive

Description

An understanding of mechanisms underlying seizure disorders depends critically on the insights provided by model systems. In particular with the development of cellular, molecular, and genetic investigative tools, there has been an explosion of basic epilepsy research. Models of Seizures and Epilepsy brings together, for the first time in 30 years, an overview of the most widely-used models of seizures and epilepsy. Chapters cover a broad range of experimental approaches (from in vitro to whole animal preparations), a variety of epileptiform phenomenology (including burst discharges and seizures), and suggestions for model characterization and validation, such as electrographic, morphologic, pharmacologic, and behavioral features. Experts in the field provide not only technical reviews of these models but also conceptual critiques - commenting on the strengths and limitations of these models, their relationship to clinical phenomenology, and their value in developing a better understanding and treatments. Models of Seizures and Epilepsy is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models for addressing key questions in the field. It also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research.

Key Features

· The first comprehensive description of animal models of epilepsy since the early 1970's

· Comprehensive analysis of "What the models model" to guide the selection of each model, and what specific questions it will answer

· Elegant examples of the use of novel technologies that can be applied in experimental epilepsy research

· World expert opinions on the clinical relevance of each model

Readership

Neurologists, epileptologists, developmental neuroscientists, medical geneticists, molecular/developmental biologists.


Details

No. of pages:
712
Language:
English
Copyright:
© Academic Press 2006
Published:
Imprint:
Academic Press
eBook ISBN:
9780080457024
Hardcover ISBN:
9780120885541

Reviews

"This book is an invaluable resource for those interested in the details of epilepsy. It will be an excellent resource for all neurologists and neurosurgeons involved in research or clinical treatment for the disease." --NEUROSURGERY QUATERLY (Mar-May 2006) "5 Stars - This is a superb and current compendium of selected models of epilepsy and their utility in investigating the various mechanisms and manifestations of epilepsy. ...This book should be on the shelf as a resource for all investigators of the mechanisms of epilepsy whether they utilize cells, slices, mice, humans, or machines. It fills an important void in the review literature that has not been comprehensively addressed for some time." --Gregory Kent Bergery, Johns Hopkins University School of Medicine, in DOODY'S (May 2006)


About the Editors

Asla Pitkänen Editor

Dr. Pitkänen is currently a Professor of Neurobiology at the University of Eastern Finland in Kuopio, Finland. She has over a 30 years’ experience in working and developing animal models of acquired epilepsy and phenotyping of epilepsy models, using histologic and molecular analysis, behavioral tests, long-term video-EEG and MRI imaging. She is a leader in epilepsy research and has participated in several NINDS on Epilepsy Models Workshops and worked in several ILAE Committees related to preclinical modelling and use of models to develop better therapies for epilepsy. She has an h-index of 52 and has over 279 publications.

Affiliations and Expertise

A.I.Virtanen Institute, University of Kuopio, Kuopio, Finland

Asla Pitkänen Editor

Dr. Pitkänen is currently a Professor of Neurobiology at the University of Eastern Finland in Kuopio, Finland. She has over a 30 years’ experience in working and developing animal models of acquired epilepsy and phenotyping of epilepsy models, using histologic and molecular analysis, behavioral tests, long-term video-EEG and MRI imaging. She is a leader in epilepsy research and has participated in several NINDS on Epilepsy Models Workshops and worked in several ILAE Committees related to preclinical modelling and use of models to develop better therapies for epilepsy. She has an h-index of 52 and has over 279 publications.

Affiliations and Expertise

A.I.Virtanen Institute, University of Kuopio, Kuopio, Finland

Philip Schwartzkroin Editor

Affiliations and Expertise

University of California, Davis, USA

Solomon Moshé Editor

Dr. Moshé is a professor of neurology, neuroscience, and pediatrics at Albert Einstein College of Medicine. He is the Director of Child Neurology and Clinical Neurophysiology and the recipient of a Martin A. and Emily L. Fisher fellowship in Neurology and Pediatrics at Albert Einstein. Dr. Moshé received his M.D. from the National University of Athens School of Medicine, Athens, Greece in 1972. He trained in pediatrics at the University of Maryland and in neurology at Albert Einstein. Since 1979, his research has focused on understanding the mechanisms underlying age-related differences in epilepsy in humans and in animal models. During the last ten years, his interest has turned to elucidating the subcortical circuitry involved in the control of seizures as a function of age and the consequences of seizures on the developing brain.

Affiliations and Expertise

Albert Einstein College of Medicine, Bronx, NY, USA