Nonlinear chromatography is a field that borders both chemical engineering and physical chemistry. In turn, the theory of nonlinear chromatography is the foundation of preparative chromatography, a separation process that has lately become of considerable interest in the pharmaceutical industry. Only chromatography is sufficiently flexible and powerful to satisfy the practical requirements encountered in most difficult separations of pharmaceuticals and pharmaceutical intermediates.
Since "nonlinear" behaviour is strictly a mathematical concept, it is difficult to leave mathematics out of any fundamental study of nonlinear chromatography. Therefore, this book will describe the different mathematical models of chromatography, examine the assumptions on which they are based, consider their properties, and discuss their solutions. All this will be done from a mathematical analysis point of view, paying considerable attention to the influence of nonlinear behavior on the results.
· Clear and simple discussions of the basic physico-chemical phenomena involved in HPLC. · Clear and complete presentation of the relevant properties of the mathematical tools involved. · Detailed analysis of nonlinear effects.
Graduate students in analytical and physical chemistry and in chemical engineering. Separation scientists and engineers in pharmaceutical companies and in manufacturers of fine chemicals.
CHAPTER I. INTRODUCTION CHAPTER II. PHYSICO-CHEMICAL BASIS OF CHROMATOGRAPHY CHAPTER III. MATHEMATICAL BASIS OF CHROMATOGRAPHY CHAPTER IV. THE PROFILES OF SINGLE COMPONENT BANDS IN LINEAR NONIDEAL CHROMATOGRAPHY CHAPTER V. SINGLE COMPONENT, IDEAL, NONLINEAR CHROMATOGRAPHY CHAPTER VI. IDEAL NONLINEAR REACTION CHROMATOGRAPHY CHAPTER VII. THE PROFILES OF SINGLE-COMPONENT BANDS IN NONLINEAR NONIDEAL CHROMATOGRAPHY CHAPTER VIII. TWO-COMPONENT IDEAL NONLINEAR CHROMATOGRAPHY CHAPTER IX. NUMERICAL ANALYSIS OF CHROMATOGRAPHY PROBLEMS
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- © Academic Press 2003
- 5th May 2003
- Academic Press
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Professor Guiochon has been a Distinguished Scientist at the University of Tennessee and Oak Ridge National Laboratory since 1987. Born and educated in France, he was a Professor of chemistry at Ecole Polytechnique and at the University of Paris until 1984 when he moved to the USA. He has been working on nolinear and preparative chromatography since 1984. He has been awarded the 1978 Silver Medal of C.N.R.S.; Honarary Doctorates by the Technical University of Budapest (Hungary) in 1991 and by the University of Pardubice (Czech Republic) in 1999; the 1991 Separation Sciences Award and the 1998 Chromatography Award of the American Chemical Society; and the EAS Award in Separation Sciences in 2001. In 1994 he received an Alexander von Humboldt Award as a Senior American Scientist.
Department of Chemistry, University of Tennessee, Knoxville, TN, USA
Anshan Institute of Iron and Steel, Anshan, Lianing, People's Republic of China