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Modeling and Control of Infectious Diseases in the Host - 1st Edition - ISBN: 9780128130520, 9780128131114

Modeling and Control of Infectious Diseases in the Host

1st Edition

With MATLAB and R

5.0 star rating 1 Review
Author: Esteban A. Hernandez-Vargas
Paperback ISBN: 9780128130520
eBook ISBN: 9780128131114
Imprint: Academic Press
Published Date: 19th February 2019
Page Count: 256
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Modeling and Control of Infectious Diseases in the Host: With MATLAB and R provides a holistic understanding of health and disease by presenting topics on quantitative decision-making that influence the development of drugs. The book presents modeling advances in different viral infections, dissecting detailed contributions of key players, along with their respective interactions. By combining tailored in vivo experiments and mathematical modeling approaches, the book clarifies the relative contributions of different underlying mechanisms within hosts of the most lethal viral infections, including HIV, influenza and Ebola. Illustrative examples for parameter fitting, modeling and control applications are explained using MATLAB and R.

Key Features

  • Provides a multi-scale framework to link within-host infection dynamics (individual level) to between-host transmission fitness (epidemiological level) in viral infectious diseases
  • Includes PK/PD modeling and simulation approaches to improve efficiency and decision-making at preclinical development phases
  • Presents a theoretic approach to schedule drug treatments


Researchers working in theoretical immunology, mathematical epidemiology, modeling, and biomathematics, as well as graduate students working in mathematical modelling in biology

Table of Contents

Part 1. Theoretical Biology Principles
1. Introduction
2. Mathematical Modeling Principles
3. Model Parameter Estimation

Part 2. Modeling Host Infectious Diseases
4. Modeling Influenza Virus Infection
5. Modeling Ebola Virus Infection
6. Modeling HIV Infection
7. HIV Evolution During Treatment

Part 3. Advanced Topics in Control Theory
8. Optimal Therapy Scheduling
9. Suboptimal Therapy Scheduling
10. PK/PD-based Impulsive Control


No. of pages:
© Academic Press 2019
19th February 2019
Academic Press
Paperback ISBN:
eBook ISBN:

About the Author

Esteban A. Hernandez-Vargas

Esteban A. Hernandez-Vargas is a research group leader and principal investigator at the Frankfurt Institute for Advanced Studies, Germany. In 2011, he obtained his PhD in Mathematics from the Hamilton Institute at the National University of Ireland. During three years, he hold a postdoctoral scientist position at the Helmholtz Centre for Infection Research (HZI) in Braunschweig, Germany. In July 2014, he founded the pioneering research group of Systems Medicine of Infectious Diseases at the HZI. Since March 2017, he and his research group moved to the Frankfurt Institute for Advanced Studies. Furthermore, he was a visiting scholar at Los Alamos National Laboratory (USA) and Universidad de Guadalajara (Mexico) and adjunct lecturer at the Otto von Guericke Universität Magdeburg, Germany. He has written more than 50 peer-reviewed publications. He is a member of the IEEE Control Systems Society, the Society of Mathematical Biology, the European Society of Virology, and the Mexican Research Council (CONACYT). Additionally, he is an Editorial Board member of Infectious Diseases of Frontiers in Medicine and Public Health Journal as well as a Research Topic Editor at Frontiers of Microbiology and Frontiers of Immunology. He is also involved in a number of IEEE and IFAC Conference Organizing Committees.

Affiliations and Expertise

Frankfurt Institute for Advanced Studies, Frankfurt am Main, Germany

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