1st Edition - January 28, 1981

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  • Editor: Arthur Zimmerman
  • eBook ISBN: 9780323148085

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Mitosis/Cytokinesis provides a comprehensive discussion of the various aspects of mitosis and cytokinesis, as studied from different points of view by various authors. The book summarizes work at different levels of organization, including phenomenological, molecular, genetic, and structural levels. The book is divided into three sections that cover the premeiotic and premitotic events; mitotic mechanisms and approaches to the study of mitosis; and mechanisms of cytokinesis. The authors used a uniform style in presenting the concepts by including an overview of the field, a main theme, and a conclusion so that a broad range of biologists could understand the concepts. This volume also explores the potential developments in the study of mitosis and cytokinesis, providing a background and perspective into research on mitosis and cytokinesis that will be invaluable to scientists and advanced students in cell biology. The book is an excellent reference for students, lecturers, and research professionals in cell biology, molecular biology, developmental biology, genetics, biochemistry, and physiology.

Table of Contents

  • List of Contributors


    I Premeiotic/Premitotic Events

    1 The Genetic Approach to the Study of the Cell Cycle

    I. Introduction

    II. The Nature of Cell Cycle Mutants

    III. The Uses of Cell Cycle Mutants

    IV. General Conclusions


    2 Calcium Regulation of Cell Cycle Events

    I. Introduction

    II. Activation of Quiescent Cells and Entry into the Division Cycle

    III. Determination of Structural Patterns

    IV. Basis for the Mitotic Oscillator

    V. Conclusions


    3 The Movements of the Nuclei during Fertilization

    I. Fertilization: Requirements, Consequences, and Prospectives

    II. Sperm Incorporation

    III. Pronuclear Movements during Fertilization

    IV. Motility during Fertilization

    V. Summary


    4 The Architecture of and Chromosome Movements within the Premeiotic Interphase Nucleus

    I. Introduction: An Overview

    II. Centromere and Nucleolar Organizer Positions and Movements

    III. From the Rabl Configuration to the Bouquet

    IV. Prospectives


    5 Chromosome Movements within Prophase Nuclei

    I. Introduction

    II. Scope

    III. Categories of Prophase Chromosome Movements

    IV. Rabl Orientation and the Bouquet

    V. Late Prophase Polarizations

    VI. Relevance, Explanations, and Implications

    VII. The Motile Mechanism: Facts and Current Personal Views

    VIII. Conclusions and Prospects


    II Mitotic Mechanisms and Approaches to the Study of Mitosis

    6 Light Microscopic Studies of Chromosome Movements in Living Cells

    I. Introduction

    II. Descriptive Studies

    III. Experimental Studies

    IV. Overview: Limitations and Potential

    V. Concluding Remarks


    7 Chromosome Micromanipulation Studies

    I. Intracellular Chromosome Micrurgy

    II. Methodology for Chromosome Micrurgy


    8 Mitotic Mutants

    I. Introduction

    II. The Advantages of Genetic Approaches

    III. Isolating Mitotic Mutants

    IV. Mitotic Mutants Defective in ß-Tubulin

    V. The Phenotypes of Mitotic Mutants

    VI. Isolating the Products of Defective Genes

    VII. Conclusion


    9 Mutants as an Investigative Tool in Mammalian Cells

    I. Introduction

    II. Temperature-Sensitive (ts) Cell Division Mutants

    III. Drug-Resistant Mutants

    IV. Concluding Remarks


    10 Immunofluorescence Studies of Cytoskeletal Proteins during Cell Division

    I. Introduction

    II. Historical View of Immunofluorescence of Mitotic Cells

    III. The Problems

    IV. Recent Advances

    V. Conclusion


    11 Mitosis through the Electron Microscope

    I. Introduction

    II. Technical Considerations

    III. Microtubules

    IV. Actin Filaments

    V. Interactions of Cytoskeletal Components

    VI. Conclusions and Future Questions


    12 Mitosis: Studies of Living Cells—A Revision of Basic Concepts

    I. Introduction

    II. Theoretical Framework

    III. Unpublished Observations

    IV. Overall Conclusions


    13 Studies of Mitotic Events Using Lysed Cell Models

    I. Introduction

    II. Use of in Vitro Microtubule Polymerization to Study the Mitotic Apparatus

    III. Use of the Lysed Cell Model to Study Spindle Assembly

    IV. Use of the Lysed Cell System for Investigation of Chromosome Motion

    V. Models for Cytokinesis Using Lysed Cells

    VI. Summary and the Future of the Lysed Cell Model in Studying Mitotic Events


    14 The Isolated Mitotic Apparatus: A Model System for Studying Mitotic Mechanisms

    I. Introduction

    II. Isolation of Mitotic Apparatus, 1954-1970

    III. Isolation of Mitotic Apparatus Since 1970

    IV. Overview and Perspectives

    V. Concluding Remarks


    15 Calmodulin and ATPases in the Mitotic Apparatus

    I. Introduction

    II. Calmodulin and the Mitotic Apparatus

    III. Calcium and the Mitotic Apparatus

    IV. Calmodulin and ATPases in the Sea Urchin Mitotic Apparatus


    III Mechanisms of Cytokinesis

    16 Mechanisms of Cytokinesis in Animal Cells

    I. Overview

    II. Investigational Results


    17 Mechanical Properties of Dividing Cells

    I. Furrowing and Growth of the Cell Surface during Cytokinesis

    II. Structure of the Dividing Cell

    III. The Site of Generation of the Motive Force of Cytokinesis

    IV. Morphological and Physical Changes in the Cell Cortex during Cytokinesis

    V. Methods for Determining Mechanical Properties of the Cell

    VI. Changes in Mechanical Properties of the Cell before and during Cytokinesis

    VII. Mechanical Properties of the Cleavage Furrow

    VIII. Rigidity Change of Non-Nucleated Fragments

    IX. Structural Changes Underlying Cytokinesis


    18 Electron Microscope Studies of Cytokinesis in Metazoan Cells

    I. Observation, or: Which Organelles Might Be Essential for Cytokinesis?

    II. Experiment, or: Are the Candidate Organelles Really Essential?

    III. Future, or: How Are the Essential Organelles Essential?


    19 Inhibitors and Stimulators in the Study of Cytokinesis

    I. Introduction

    II. Results of Studies with Selected Agents

    III. Conclusions


    20 Cell Division: A Commentary




Product details

  • No. of pages: 498
  • Language: English
  • Copyright: © Academic Press 1981
  • Published: January 28, 1981
  • Imprint: Academic Press
  • eBook ISBN: 9780323148085

About the Editor

Arthur Zimmerman

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