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Mitochondrial Physiology and Vegetal Molecules - 1st Edition - ISBN: 9780128215623

Mitochondrial Physiology and Vegetal Molecules

1st Edition

Therapeutic Potential of Natural Compounds on Mitochondrial Health

Editor: Marcos Roberto de Oliveira
Paperback ISBN: 9780128215623
Imprint: Academic Press
Published Date: 1st August 2021
Page Count: 650
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Mitochondrial Physiology and Vegetal Molecules: Therapeutic Potential of Natural Compounds on Mitochondrial Health provides a comprehensive overview of mitochondrial physiology throughout the human lifespan, along with the effects of molecules of vegetal origin on mitochondrial health. The book is structured into two parts, providing a balance of both foundational and applied content. Sections present an overview of mitochondrial physiology, including its structure, dynamics, biogenesis, membranes, DNA transcription, and translation in mitochondria. Specific chapters focus on apoptosis, the effect of specific vegetable-derived molecules on mitochondrial health, including anthocyanins, caffeine, cannabinoids, carnosic and rosmarinic acids, citrus flavonoids, polyphenols, pterostilbene, resveratrol, and sulforaphane, among others.

This book is a complete resource for researchers in this exciting field. Its comprehensive coverage makes it particularly interesting to bioscience researchers who are willing to understand the foundations of mitochondrial physiology throughout the human lifespan. Clinician researchers, MDs, nutritionists, pharmacologists and sports scientists may also be attracted to its detailed information on the health effects of vegetal origin molecules on the organelle.

Key Features

  • Contains detailed information on plant products and their effect on mitochondria
  • Proposes therapies and reviews mechanisms of absorption at the cellular level
  • Discusses the limited bioavailability of plant molecules/compounds in the human organism
  • Includes coverage of specific conditions such as Sports and affective disorders, among others
  • Presents the protective effects of plant products in mitochondrial health through all stages of life


Clinician researchers, MDs, nutritionists, pharmacologists, and sports scientists

Table of Contents

Part I Overview of the mitochondrial function and dynamics in health and disease
1. Mitochondrial structure and function
2. Mitochondrial dynamics: fusion and fission
3. Mitochondrial biogenesis
4. DNA transcription and translation in the mitochondria
5. Mitochondrial redox biology: reactive species production and antioxidant defenses
6. Mitochondria and apoptosis

Part II Mitochondrial dysfunction in human diseases and intoxication
7. Mitochondrial dysfunction in neurodegenerative diseases
8. Mitochondrial dysfunction, cerebral amyloid angiopathy, and Alzheimer’s disease
9. Mitochondrial dysfunction in major depression
10. Mitochondrial dysfunction in bipolar disorder
11. Mitochondrial dysfunction in schizophrenia
12. Mitochondrial dysfunction in epilepsies
13. Mitochondrial dysfunction in autism
14. Mitochondrial dysfunction in inborn errors of metabolism
15. Mitochondrial dysfunction in cardiovascular diseases
16. Mitochondrial dysfunction in diabetes mellitus
17. Mitochondrial dysfunction and metabolic syndrome
18. Mitochondrial dysfunction in liver diseases
19. Mitochondrial dysfunction in kidney diseases
20. Lung disease and mitochondria
21. Mitochondrial dysfunction in immune diseases
22. Aging, mitochondria, and autophagy
23. Skin aging and mitochondria
24. Mitochondrial dysfunction in the skeletal muscle
25. Mitochondrial dysfunction in hypervitaminosis A
26. The effects of agrochemicals on the mitochondria
27. Heavy metals and mitochondria
28. Methamphetamine and mitochondria
29. Cocaine and mitochondria

Part III The effects of plant molecules on the mitochondria in health and disease
30. Carnosic acid and brain mitochondria: focus on neurodegenerative diseases
31. Pinocembrin and brain mitochondria: focus on neurodegenerative diseases
32. The effects of sulforaphane on the brain mitochondria
33. Resveratrol and brain mitochondria
34. Promoting mitochondrial protection in epilepsy: role for herbal molecules
35. The effects of melatonin on the mitochondria: focus on mood disorders and schizophrenia
36. Mitochondria, amyloid peptides, and polyphenols
37. The effects of the coffee diterpene kahweol on the mitochondria
38. Traditional Chinese Medicine and heart mitochondria
39. Pentacyclic triterpenes, mitochondrial dysfunction, and metabolic syndrome
40. Curcumin and liver mitochondria
41. Catechins, hepatotoxicity, and the mitochondria
42. Mitochondrial protection in lung diseases: role for herbal agents
43. Resveratrol and muscle mitochondria
44. Increasing resveratrol bioavailability: A therapeutic challenge focusing on the mitochondria
45. Plant molecules, mitochondria, and physical exercises
46. Antiaging effects of natural agents in the skin: focus on the mitochondria
47. Quercetin and mitochondria
48. The effects of curcumin on the mitochondria
49. The effects of epigallocatechin gallate on the mitochondria
50. Plant molecules, mitochondria, and cancer therapy
51. The Nrf2/Heme oxygenase-1 axis, plant molecules and the mitochondria
52. The role of plant molecules on the prevention and/or treatment of mitochondria-related intoxication
53. Strategies against methylglyoxal-induced mitochondrial dysfunction: focus on plant molecules


No. of pages:
© Academic Press 2021
1st August 2021
Academic Press
Paperback ISBN:

About the Editor

Marcos Roberto de Oliveira

Dr. Marcos de Oliveira is currently an Associate Professor at the Federal University of Mato Grosso, Brazil. He holds an undergraduate degree in Biological Sciences, with a masters and PhD in Biochemistry. He has conducted research in the field of mitochondrial physiology for the past 15 years and has published several papers in the field showing the effects of different toxicants on the mitochondria-related parameters, including mitochondrial function, mitochondrial redox biology, mitochondria-associated bioenergetics, and mitochondria-related apoptosis. Dr. Olivera has published over 80 articles in international peer-reviewed journals and has collaborated with over 140 co-authors.

Affiliations and Expertise

Associate Professor, Federal University of Mato Grosso, Mato Grosso, Brazil

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