Mitochondrial Intoxication

Mitochondrial Intoxication

1st Edition - December 1, 2022

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  • Editor: Marcos Roberto de Oliveira
  • Paperback ISBN: 9780323884624

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Mitochondrial Intoxication explores the effects toxic molecules can have upon mitochondrial physiology in the human body. Each chapter is dedicated to a specific toxicant, including pollutants, food additives, illicit and pharmaceutical drugs, and heavy metals. This book considers the implications and impact these have upon mitochondria and the diseases that can result from dysfunction and impairment in the human body. Furthermore, the book provides an overview of mitochondrial physiology and assesses the advances and challenges in testing mitochondrial toxicity. Case studies exploring mitochondrial intoxication in pregnancy and in the geriatric population are also included. This is a comprehensive reference on the main toxicants impacting mitochondria in the human body, and the consequences this can have for health and disease.

Key Features

  • Features a wide range of toxicants and their effects on mitochondrial physiology
  • Covers molecular markers of mitochondrial intoxication
  • Includes case studies that illustrate the health impacts of toxicity upon mitochondria
  • Considers future directions regarding the study of mitochondrial intoxication


Researchers in cell biology, molecular biology, toxicology, biochemistry, and those working with mitochondrial dysfunction and toxicants; Graduate, postgraduate and PhD students in related areas

Table of Contents

  • 1. Mitochondrial physiology: An overview 2. Molecular markers of mitochondrial intoxication
    3. Drug-induced mitochondrial impairment: Mechanisms and testing systems
    4. Challenges in mitochondrial profiling during pre-clinical studies
    5. Acrylamide
    6. The effects of air pollution toxicants on the mitochondria
    7. Aflatoxin B
    8. The effects of the alcohol abuse against the mitochondria. Functional consequences for liver, muscle, and the brain
    9. Aluminum
    10. Discovery of amiodarone mitochondrial toxicity in liver and beyond
    11. Ammonia
    12. The mitochondrial disruption as a contributing factor for the neurotoxicity of amphetamines
    13. Anthracycline
    14. Antidepressants, mood stabilizing drugs and mitochondrial function; for better or for worse
    15. The effects of antiretroviral drugs on the mitochondria
    16. Arsenic
    17. Mechanisms of bisphenol A toxicity in mitochondria
    18. Chemotherapeutic drugs
    19. Cuprizone
    20. Delta‐9‐tetrahydrocannabinol (Cannabis sativa)
    21. Diclofenac
    22. Food additives
    23. Mitochondria as a toxicological target for fungicides
    24. The effects of methylglyoxal on the mitochondria
    25. The effects of mercury on the mitochondria
    26. Organohalogens
    27. The effects of organophosphate pesticides on the mitochondria
    28. Oxygen toxicity
    29. Paracetamol/Acetaminophen
    30. Plant molecules (Mitochondrial intoxication induced by plant molecules)
    31. Polychlorinated biphenyls (PCBs)
    32. The effects of polycyclic aromatic hydrocarbons on the mitochondria
    33. Pyrethroids
    34. Redox cycling compounds (Mitochondrial toxicity of redox cycling compounds)
    35. The effects of sodium nitrate on the mitochondria
    36. Zinc

Product details

  • No. of pages: 765
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: December 1, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780323884624

About the Editor

Marcos Roberto de Oliveira

Dr Oliveira PhD earned his bachelor’s degree in Biological Sciences at Federal University of Rio Grande do Sul (UFRGS) in 2005, followed by a Master’s and a Ph.D. in Biochemistry from the same institution. His research focuses on the neuroprotection mediated by natural molecules and involves studies on mitochondrial physiology, redox biology, bioenergetics, and inflammation in both in vitro and in vivo experimental models. Dr Oliveira has published numerous articles on peer-reviewed Journals, including Molecular Neurobiology, Chemico-Biological Interactions, Biotechnology Advances, and Oxidative Medicine and Cellular Longevity. He has also edited a book on the effects of plant molecules on the mitochondria Mitochondrial Physiology and Vegetal Molecules: Therapeutic Potential of Natural Compounds on Mitochondrial Health and a book on the role of mitochondrial dysfunction in both neurological disturbances and intoxication Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine.

Affiliations and Expertise

Professor, Department of Biochemistry, Federal University of Rio Grande do Sul, Universidade Federal do Rio Grande do Sul (UFRGS), Instituto de Ciências Básicas da Saude (ICBS), Departamento de Bioquímica, Rua Ramiro Barcelos, Brazil

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