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Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine provides a comprehensive overview of mitochondrial dysfunction and current strategies for targeting the organelle. Based on the most current research, the editor lined up a team of worldwide experts to cover the most exciting research in the area, considering the impact through the human life span.
This book is structured in two parts that provide a good balance of foundational and applied content. Part I deals with an overview of mitochondrial dysfunction and its role in the aging process, including metabolic diseases, neuro-affective and neurodegenerative disorders, sepsis, and toxicological aspects. Part II covers therapeutic substance delivery to mitochondria with a focus on cancer, neurodegenerative diseases, and increasing the bioavailability of natural compounds of interest. Several nanoscale strategies are described.
Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine is a complete resource for researchers in this exciting field. Its comprehensive coverage makes this book particularly interesting to bioscience researchers looking to understand the foundations of mitochondrial health throughout the human life span. Additionally, clinician researchers, medical doctors, nutritionists, pharmacologists, and sports scientists may be attracted to the detailed information on the organelle-targeted delivery strategies.
- Contains detailed information on mitochondrial dysfunction
- Reviews our current understanding of the role of mitochondria in aging
- Includes coverage of specific conditions, including sports and affective disorders, among others
- Discusses mitochondria targeted delivery of therapeutic compounds
Researchers in Bioscience (from PhD level and up). Clinician Researchers (Human disease) - MD (Pharmacology, Nutrition) and DVM - Graduate students (nutrition, medicine, pharmacology)
Part I - Mitochondrial Dysfunction
1. Mitochondrial dysfunction and affective disorders: Focus on diet, exercise, and aging
2. Mitochondrial dysfunction in inborn errors of metabolism
3. Impaired mitochondrial dynamics in disease
4. Mitochondrial dysfunction in metabolic disorders
5. Mitochondrial dysfunction and autophagy in neurodegenerationin neurodegeneration
6. Mitochondrial dysfunction in sepsis
7. Drug or toxin induced mitochondrial toxicity
8. Aging, mitochondria, and autophagy
9. Skin aging and mitochondria
Part II - Strategies utilized to deliver natural molecules to the mitochondria
10. Organelle targeting: focus on the mitochondria
11. Nanotechnology, mitochondria, and cancer
12. Nanomaterials aimed towards the cardiac mitochondria: of therapeutics to nanosafety
13. Increasing resveratrol bioavailability: a therapeutic challenge focusing on the mitochondria
14. Advances in nanotechnology-related strategies against melanoma
15. Challenges in the delivery of polyphenols to cancer cells
16. Challenges in the nanoscale delivery systems development in the pharmaceutical and nutraceutical markets
17. Therapeutic implications of targeting antioxidants to the mitochondria
18. Nanomedicines and phytochemicals targeting Alzheimer’s Disease
19. Mitochondria-targeted drugs and immune function
20. Polymeric Drug Delivery Systems for Mitigating Oxidative Stress
21. Polyphenols and the Microbiota: A Challenge in Mitochondrial Therapy
- No. of pages:
- © Academic Press 2021
- 15th July 2021
- Academic Press
- Paperback ISBN:
- eBook ISBN:
Marcos Roberto de Oliveira earned his bachelor’s degree in Biological Sciences at Federal University of Rio Grande do Sul (UFRGS) in 2005, followed by a Master’s and a Ph.D. in Biochemistry from the same institution. Dr. Marcos Roberto de Oliveira’s research during this period focused on the toxic effects of vitamin A on mitochondria. Currently, Dr. Marcos Roberto de Oliveira is a professor at UFRGS. His current research focuses on the mechanism of action by which natural molecules promote mitochondrial protection in human and animal cells.
Associate Professor, Federal University of Mato Grosso, Cuiabá, Mato Grosso, Brazil
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