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Mitochondrial Dysfunction and Nanotherapeutics - 1st Edition - ISBN: 9780323856669

Mitochondrial Dysfunction and Nanotherapeutics

1st Edition

Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine

Editor: Marcos Oliveira
Paperback ISBN: 9780323856669
Imprint: Academic Press
Published Date: 1st August 2021
Page Count: 666
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Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases and Nanotechnology-Related Strategies in Mitochondrial Medicine provide a comprehensive overview of the Mitochondrial disfunction, and current strategies for targeting the organelle. Based on the most current research, the Editor lined up a team of worldwide experts to cover the most exciting research in the area, considering the impact through the human life span.

The book is structured in two parts that provide a good balance of foundational and applied content around the theme. Part I deals with an overview of mitochondrial dysfunction and its role in the aging process, including metabolic diseases, neuro affective and neurodegenerative disorders, sepsis, and toxicology. Part II covers therapeutic substance delivery to the organelle, focused on cancer, neurodegenerative diseases and increasing the bioavailability of natural compounds of interest. Several nano-scale strategies are described.

Mitochondrial Dysfunction and Nanotherapeutics: Aging and Diseases and Nanotechnology-Related Strategies in Mitochondrial Medicine is a complete resource for researchers in this exciting field. Its comprehensive coverage makes it particularly interesting to bioscience researchers willing to understand the foundations of mitochondrial health through the human lifespan. Clinician Researchers, MDs, nutritionists, pharmacologists, and sports scientists may be attracted to the detailed information on the organelle targeted delivery strategies.

Key Features

  • Contains detailed information on mitochondrial dysfunction
  • Review the current understanding of the role of the mitochondria in aging
  • Includes coverage of specific conditions such as Sports and affective disorders, among others
  • Discusses mitochondria targeted delivery of therapeutic compounds


Researchers in Bioscience (from PhD level and up). Clinician Researchers (Human disease) - MD (Pharmacology, Nutrition) and DVM - Graduate students (nutrition, medicine, pharmacology)

Table of Contents

Part I - Mitochondrial Dysfunction
1. Mitochondrial dysfunction and affective disorders: Focus on diet, exercise, and aging
2. Mitochondrial dysfunction in autism
3. Mitochondrial dysfunction in inborn errors of metabolism
4. Impaired mitochondrial dynamics in disease
5. Mitochondrial dysfunction in metabolic disorders
6. Mitochondrial dysfunction and autophagy in neurodegeneration
7. Mitochondrial dysfunction in sepsis
8. Mitochondrial intoxication
9. Drug or toxin induced mitochondrial toxicity
10. Aging, mitochondria, and autophagy
11. Skin aging and mitochondria
12. Mitohormesis

Part II - Strategies utilized to deliver natural molecules to the mitochondria
13. Organelle targeting: Focus on the mitochondria
14. Nanotechnology, mitochondria, and cancer
15. Nanomaterials aimed towards the cardiac mitochondria: of therapeutics to nanosafety
16. Increasing resveratrol bioavailability: a therapeutic challenge focusing on the mitochondria
17. Advances in the delivery of nanotechnology-based bioactives
18. Advances in nanotechnology-related strategies against melanoma
19. Challenges in the delivery of polyphenols to cancer cells
20. Challenges in the nanoscale delivery systems development in the pharmaceutical and nutraceutical markets
21. Therapeutic implications of targeting antioxidants to the mitochondria
22. Nanomedicines and phytochemicals targeting Alzheimer's Disease
23. Mitochondria-targeted drugs and immune function
24. Polymeric Drug Delivery Systems for Mitigating Oxidative Stress
25. Polyphenols and the Microbiota: A Challenge in Mitochondrial Therapy


No. of pages:
© Academic Press 2021
1st August 2021
Academic Press
Paperback ISBN:

About the Editor

Marcos Oliveira

Dr. Marcos de Oliveira is currently an Associate Professor at the Federal University of Mato Grosso, Brazil. He holds an undergraduate degree in Biological Sciences, with a masters and PhD in Biochemistry. He has conducted research in the field of mitochondrial physiology for the past 15 years and has published several papers in the field showing the effects of different toxicants on the mitochondria-related parameters, including mitochondrial function, mitochondrial redox biology, mitochondria-associated bioenergetics, and mitochondria-related apoptosis. Dr. Olivera has published over 80 articles in international peer-reviewed journals and has collaborated with over 140 co-authors.

Affiliations and Expertise

Associate Professor, Federal University of Mato Grosso, Mato Grosso, Brazil

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