Mitochondrial Dysfunction and Nanotherapeutics

Mitochondrial Dysfunction and Nanotherapeutics

Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine

1st Edition - July 15, 2021

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  • Editor: Marcos Oliveira
  • Paperback ISBN: 9780323856669
  • eBook ISBN: 9780323886185

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Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine provides a comprehensive overview of mitochondrial dysfunction and current strategies for targeting the organelle. Based on the most current research, the editor lined up a team of worldwide experts to cover the most exciting research in the area, considering the impact through the human life span. This book is structured in two parts that provide a good balance of foundational and applied content. Part I deals with an overview of mitochondrial dysfunction and its role in the aging process, including metabolic diseases, neuro-affective and neurodegenerative disorders, sepsis, and toxicological aspects. Part II covers therapeutic substance delivery to mitochondria with a focus on cancer, neurodegenerative diseases, and increasing the bioavailability of natural compounds of interest. Several nanoscale strategies are described. Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine is a complete resource for researchers in this exciting field. Its comprehensive coverage makes this book particularly interesting to bioscience researchers looking to understand the foundations of mitochondrial health throughout the human life span. Additionally, clinician researchers, medical doctors, nutritionists, pharmacologists, and sports scientists may be attracted to the detailed information on the organelle-targeted delivery strategies.

Key Features

  • Contains detailed information on mitochondrial dysfunction
  • Reviews our current understanding of the role of mitochondria in aging
  • Includes coverage of specific conditions, including sports and affective disorders, among others
  • Discusses mitochondria targeted delivery of therapeutic compounds


Researchers in Bioscience (from PhD level and up). Clinician Researchers (Human disease) - MD (Pharmacology, Nutrition) and DVM - Graduate students (nutrition, medicine, pharmacology)

Table of Contents

  • Part I - Mitochondrial Dysfunction

    1. Mitochondrial dysfunction and affective disorders: Focus on diet, exercise, and aging

    2. Mitochondrial dysfunction in inborn errors of metabolism

    3. Impaired mitochondrial dynamics in disease

    4. Mitochondrial dysfunction in metabolic disorders

    5. Mitochondrial dysfunction and autophagy in neurodegenerationin neurodegeneration

    6. Mitochondrial dysfunction in sepsis

    7. Drug or toxin induced mitochondrial toxicity

    8. Aging, mitochondria, and autophagy

    9. Skin aging and mitochondria

    Part II - Strategies utilized to deliver natural molecules to the mitochondria

    10. Organelle targeting: focus on the mitochondria

    11. Nanotechnology, mitochondria, and cancer

    12. Nanomaterials aimed towards the cardiac mitochondria: of therapeutics to nanosafety

    13. Increasing resveratrol bioavailability: a therapeutic challenge focusing on the mitochondria

    14. Advances in nanotechnology-related strategies against melanoma

    15. Challenges in the delivery of polyphenols to cancer cells

    16. Challenges in the nanoscale delivery systems development in the pharmaceutical and nutraceutical markets

    17. Therapeutic implications of targeting antioxidants to the mitochondria

    18. Nanomedicines and phytochemicals targeting Alzheimer’s Disease

    19. Mitochondria-targeted drugs and immune function

    20. Polymeric Drug Delivery Systems for Mitigating Oxidative Stress

    21. Polyphenols and the Microbiota: A Challenge in Mitochondrial Therapy


Product details

  • No. of pages: 600
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: July 15, 2021
  • Imprint: Academic Press
  • Paperback ISBN: 9780323856669
  • eBook ISBN: 9780323886185

About the Editor

Marcos Oliveira

Dr Oliveira PhD earned his bachelor’s degree in Biological Sciences at Federal University of Rio Grande do Sul (UFRGS) in 2005, followed by a Master’s and a Ph.D. in Biochemistry from the same institution. His research focuses on the neuroprotection mediated by natural molecules and involves studies on mitochondrial physiology, redox biology, bioenergetics, and inflammation in both in vitro and in vivo experimental models. Dr Oliveira has published numerous articles on peer-reviewed Journals, including Molecular Neurobiology, Chemico-Biological Interactions, Biotechnology Advances, and Oxidative Medicine and Cellular Longevity. He has also edited a book on the effects of plant molecules on the mitochondria Mitochondrial Physiology and Vegetal Molecules: Therapeutic Potential of Natural Compounds on Mitochondrial Health and a book on the role of mitochondrial dysfunction in both neurological disturbances and intoxication Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine.

Affiliations and Expertise

Professor, Department of Biochemistry, Federal University of Rio Grande do Sul, Universidade Federal do Rio Grande do Sul (UFRGS), Instituto de Ciências Básicas da Saude (ICBS), Departamento de Bioquímica, Rua Ramiro Barcelos, Brazil

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