Mitochondrial Dysfunction and Nanotherapeutics

Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine provides a comprehensive overview of mitochondrial dysfunction and current strategies for targeting the organelle. Based on the most current research, the editor lined up a team of worldwide experts to cover the most exciting research in the area, considering the impact through the human life span.

This book is structured in two parts that provide a good balance of foundational and applied content. Part I deals with an overview of mitochondrial dysfunction and its role in the aging process, including metabolic diseases, neuro-affective and neurodegenerative disorders, sepsis, and toxicological aspects. Part II covers therapeutic substance delivery to mitochondria with a focus on cancer, neurodegenerative diseases, and increasing the bioavailability of natural compounds of interest. Several nanoscale strategies are described.

Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine is a complete resource for researchers in this exciting field. Its comprehensive coverage makes this book particularly interesting to bioscience researchers looking to understand the foundations of mitochondrial health throughout the human life span. Additionally, clinician researchers, medical doctors, nutritionists, pharmacologists, and sports scientists may be attracted to the detailed information on the organelle-targeted delivery strategies.

• Contains detailed information on mitochondrial dysfunction
• Reviews our current understanding of the role of mitochondria in aging
• Includes coverage of specific conditions, including sports and affective disorders, among others
• Discusses mitochondria targeted delivery of therapeutic compounds

Researchers in Bioscience (from PhD level and up). Clinician Researchers (Human disease) - MD (Pharmacology, Nutrition) and DVM - Graduate students (nutrition, medicine, pharmacology)

Part I - Mitochondrial Dysfunction

1. Mitochondrial dysfunction and affective disorders: Focus on diet, exercise, and aging

2. Mitochondrial dysfunction in inborn errors of metabolism

3. Impaired mitochondrial dynamics in disease

4. Mitochondrial dysfunction in metabolic disorders

5. Mitochondrial dysfunction and autophagy in neurodegenerationin neurodegeneration

6. Mitochondrial dysfunction in sepsis

7. Drug or toxin induced mitochondrial toxicity

8. Aging, mitochondria, and autophagy

9. Skin aging and mitochondria

Part II - Strategies utilized to deliver natural molecules to the mitochondria

10. Organelle targeting: focus on the mitochondria

11. Nanotechnology, mitochondria, and cancer

12. Nanomaterials aimed towards the cardiac mitochondria: of therapeutics to nanosafety

13. Increasing resveratrol bioavailability: a therapeutic challenge focusing on the mitochondria

14. Advances in nanotechnology-related strategies against melanoma

15. Challenges in the delivery of polyphenols to cancer cells

16. Challenges in the nanoscale delivery systems development in the pharmaceutical and nutraceutical markets

17. Therapeutic implications of targeting antioxidants to the mitochondria

18. Nanomedicines and phytochemicals targeting Alzheimer’s Disease

19. Mitochondria-targeted drugs and immune function

20. Polymeric Drug Delivery Systems for Mitigating Oxidative Stress

21. Polyphenols and the Microbiota: A Challenge in Mitochondrial Therapy