Mitochondria in Neurological Disorders

Mitochondria in Neurological Disorders

1st Edition - December 1, 2022

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  • Editor: Rajat Sandhir
  • Paperback ISBN: 9780128217313

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Mitochondria in Neurological Diseases highlights various therapeutic approaches targeting mitochondria in neurological conditions. Focused on diverse neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, depression, and Amyotrophic lateral sclerosis, topics span basic mitochondrial physiology to mitochondrial dynamics and to the altered states of the nervous system. This book is appropriate for anyone interested in learning more about the physiological and pathophysiological functions of mitochondria in the nervous system.

Key Features

  • Provides up-to-date information on role of mitochondria in nervous system for graduate students and researchers
  • Presents chapters on energy substrate utilization, calcium handling, mitochondria-organelle communication, and cell signaling
  • Discusses recent techniques in understanding mitochondrial functions in the nervous system
  • Emphasizes the role of altered mitochondrial functions in various neurological conditions and their potential treatment strategies for targeting mitochondria
  • Includes chapter references (key articles, books, protocols) for additional detailed study


Neuroscientists, clinicians, biomedical scientists, graduate students in biological and biomedical sciences, post-doctoral fellows, and researchers with interest in mitochondrial biology especially neurobiology

Table of Contents

  • 1. Mitochondria in functions of nervous system
    2. Mitochondrial calcium homeostasis in synaptic functions
    3. Mitochondrial regulation of neuronal plasticity
    4. Communication between mitochondria and other organelles
    5. Axoplasmic mitochondrial transport: From Molecules to Mechanisms
    6. Yeast as a model for studying human neurodegenerative disorders
    7. Sex differences in mitochondrial metabolism
    8. Mitochondrial oxidative stress and neurodegeneration
    9. Mitochondrial metabolism in neurological disorders
    10. Altered mitochondrial signalling in neurodegenerative conditions
    11. Mitochondrial DNA, base excision repair and neurodegeneration
    12. microRNAs regulating mitochondrial functions in brain
    13. Mitochondrial Chaperones in Neurodegenerative Disorders
    14. Proteomic profiling of mitochondria in neurodegenerative conditions
    15. Association of mitochondrial genetic variants with neurological disorders
    16. Mitochondrial dynamics in diseases of nervous system
    17. Mitochondrial thiol dioxygenases in diseases of the nervous system
    18. Mitophagy in Neurodegenerative Diseases
    19. Mitochondria and neuroinflammation
    20. Mitochondrial functions in Alzheimer’s Disease
    21. Mitochondria in Amyotrophic lateral sclerosis
    22. Pathways involved in mitochondrial dysfunctions in Huntington’s Disease
    23. Mitochondrial cascades in Parkinson’s Disease
    24. Mitochondrial dysfunctions in Psychiatric Disorders
    25. Mitochondria in Brain Injury
    26. Mitochondrial epigenetics in neurodegeneration
    27. Transmitochondrial Cybrids: A cellular model to study mutant mitochondria
    28. Targeting mitochondria in neurodegenerative disorders
    29. Mitochondrial modulators in neuroprotection
    30. Polyphenols and mitochondria in neurodegneration
    31. Transplantation of mitochondria in neurodegenerative disorders

Product details

  • No. of pages: 500
  • Language: English
  • Copyright: © Academic Press 2024
  • Published: December 1, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780128217313

About the Editor

Rajat Sandhir

Dr. Sandhir obtained his M.Sc and Ph.D. degree in Biochemistry from the Postgraduate Institute of Medical Education and Research, Chandigarh. He has been with the Panjab University, Chandigarh for more than 20 years. His research interests are to understand the biochemical and molecular mechanisms involved in development of neurodegenerative conditions like metabolic encephalopathies, dementia's and brain injury with a particular interest to understand role of oxidative stress, mitochondria and alterations in Blood-Brain-Barrier. In addition, his interest is also to identify neuroprotective strategies that could ameliorate neurodegenerative conditions. His recent work focuses on mitochondrial dysfunctions in various neurological conditions and to identify various mitochondrial modulators that may be beneficial in protecting nervous system He has over 175 papers to his credit and has mentored over two-dozen Ph.D. students. He has an h-index of 40 and i10 index of 97.

Affiliations and Expertise

Postgraduate Institute of Medical Education and Research, Chandigarh, India

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