Mitochondria as a Key Intracellular Target of Thallium Toxicity

Mitochondria as a Key Intracellular Target of Thallium Toxicity

1st Edition - June 1, 2022

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  • Author: Sergey Korotkov
  • Paperback ISBN: 9780323955317
  • eBook ISBN: 9780323955324

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Description

Mitochondria as a Key Intracellular Target of Thallium Toxicity presents a new hypothesis that explains the decrease in antioxidant defense of thallium poisoning and proposes a new model for studying the transport of inorganic cations across the inner mitochondrial membrane. Readers will learn about the toxicity of thallium and its compounds, the toxicology of thallium, the toxic thallium effects on cells, and the effects of thallium on mitochondria. In addition, the book lists the pathways and mechanisms of thallium transport into cells and mitochondria, including information on toxicity that has been analyzed at both the cellular and subcellular levels. The increase in human contact with the toxic trace element thallium is associated with industry development, the release of metal into the environment from various rocks, and the use of special isotope techniques for studying the vascular bed.

Key Features

  • Highlights the differences between the toxic effect of thallium and the action of other heavy metals on cells and mitochondria
  • Explains why the toxicity of thallium in experiments in vivo is higher than that of bivalent heavy metals
  • Discusses the applied in vitro model when searching for new inhibitors of the mitochondrial permeability transition pore

Readership

Researchers in cell biology, biochemistry, biochemical toxicology, ecology, neurobiology and environmental science. Clinicians; Graduate students

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Introduction
  • Abstract
  • List of abbreviations:
  • Chapter 1. Toxicity of thallium and its compounds
  • 1.1. Thallium and its compounds: chemical and toxic properties, distribution, and release into the environment
  • 1.2. Thallium toxicity to biological organisms (humans, animals, and plants)
  • 1.3. Classification, symptomatology, diagnosis, and treatment of thallium poisoning
  • 1.4. Methods of thallium analysis in biological samples
  • Chapter 2. Toxicology of thallium
  • 2.1. The toxic effect of thallium on the human body and animals
  • 2.2. The toxic effect of thallium compounds on body systems
  • 2.3. Toxic effects of thallium on aquatic protozoa and unicellular organisms
  • Chapter 3. Toxic thallium effects on cells
  • 3.1. Molecular mechanisms of thallium transport across cell membranes: use of isotopes and ion channel inhibitors
  • 3.2. Thallium toxicity mechanisms on mammalian cells
  • 3.3. Interaction of Tl+ and Tl3+ with molecular thiol groups
  • Chapter 4. Effect of thallium on mitochondria
  • 4.1. Heavy metal effects on isolated mitochondria
  • 4.2. Effect of thallium on the inner membrane potential and ion permeability and the mitochondrial respiration
  • 4.3. Thallium effects on the concentration of free thiol groups in mitochondrial proteins
  • 4.4. Tl+induces the opening of the mitochondrial permeability transition pore in the inner membrane of calcium-loaded mitochondria: The effects of the pore inhibitors
  • 4.5. The role of calcium sites and potassium channels of the inner membrane in the Tl+-induced MPTP opening
  • 4.6. The dependence of the Tl+-induced MPTP opening in the inner membrane of rat liver mitochondria on the adenine nucleotide translocase conformation and the phosphate symporter state
  • 4.7. Conclusing remarks
  • Index

Product details

  • No. of pages: 278
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: June 1, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780323955317
  • eBook ISBN: 9780323955324

About the Author

Sergey Korotkov

Sergey Korotkov is a Leading Researcher in the Laboratory of Inorganic Ions’ Biochemistry at the Sechenov Institute of Evolutionary Physiology and Biochemistry. He graduated from the Chemical Department of St. Petersburg State University in 1979 and defended his PhD thesis at Russian Academy of Sciences in 1987.

Affiliations and Expertise

Leading Researcher, Russian Academy of Sciences, Sechenov Institute of Evolutionary Physiology and Biochemistry, St. Petersburg, Russia

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