Mims' Pathogenesis of Infectious Disease

5th Edition

Authors: Anthony Nash Cedric Mims John Stephen
Paperback ISBN: 9780124982642
eBook ISBN: 9780080538501
Imprint: Academic Press
Published Date: 25th September 2000
Page Count: 464
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Mims' Pathogenesis of Infectious Disease is the landmark book in the field of infectious disease. The new, revised edition of this work provides a comprehensive, up-to-date description of the mechanisms of microbial infection and the pathogenesis of infectious disease. Presented in a clear, accessible style, it deals in an integrated manner with the spectrum of microorganisms, describing the factors common to all infectious diseases. Molecular biology, pathology, and immunology are brought together to explain the mechanisms for spread, immune response, and recovery.

Key Features

@introbul:Key features and of the 5th edition include: @bul:* Microbial gene sequencing

  • Up-to-date picture of the global burden of infectious diseases
  • Role of bacterial virulence factors in vivo, as contrasted with possibilities based on in vitro evidence
  • Latest data on combination vaccines, the promise of edible vaccines
  • The spread of antibiotic resistance genes among bacteria
  • HIV1 and HIV2; molecular biology, pathogenesis and origin
  • Latest data on tuberculosis - the number one infectious disease worldwide
  • Recent work on papillomaviruses, herpesviruses, BSE and variant CJD
  • Latest data on microbial evasion of immune defences
  • Origin and molecular biology of pandemic influenza
  • Significance of toxins
  • An update on vaccines, prions, immune evasion, microbial ligands and receptors


Undergraduate and graduate students in microbiology and immunology, medical students, and others new to the field of microbiology and infectious diseases.

Table of Contents

Preface to the Fifth Edition Preface to the Fourth Edition Preface to the Third Edition Preface to the Second Edition Preface to the First Edition 1 General Principles References 2 Attachment to and Entry of Microorganisms into the Body Introduction Adhesion/Entry: Some General Considerations The Skin Respiratory Tract Gastro-Intestinal Tract Oropharynx Urinogenital Tract Conjunctiva The Normal Microbial Flora Exit of Microorganisms From the Body References 3 Events Occurring Immediately After the Entry of the Microorganism Growth in Epithelial Cells Intracellular Microorganisms and Spread through the Body Subepithelial Invasion Nutritional Requirements of Invading Microbes References 4 The Encounter with the Phagocytic Cell and the Microbe's Answers Cell Biology of Phagocytosis Phagocytosis in Polymorphonuclear Leucocytes Phagocytosis in Macrophages Microbial Strategy in Relation to Phagocytes Growth in the Phagocytic Cell Killing the Phagocyte Entry into the Host Cell Other than by Phagocytosis Consequences of Defects in the Phagocytic Cell Summary References 5 The Spread of Microbes through the Body Direct Spread Microbial Factors Promoting Spread Spread via Lymphatics Spread via the Blood Spread via Other Pathways References 6 The Immune Response to Infection Antibody Response T-Cell-Mediated Immune Response Natural Killer Cells Macrophages, Polymorphs and Mast Cells Complement and Related Defense Molecules Conclusions Concerning the Immune Response to Microorganisms References 7 Microbial Strategies in Relation to the Immune Response Infection Completed before the Adaptive Immune Response Intervenes Induction of Immunological Tolerance Immunosuppression Absence of a Suitable Target for the I


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Academic Press
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About the Author

Anthony Nash

Tony Nash is Emeritus Professor of Infectious Diseases at the University of Edinburgh. He has had a distinguished career i the field of viral pathogenesis in which he has over a 150 publications. He is a Fellow of the Royal Society of Edinburgh and of the Academy of medical sciences of the UK.

Affiliations and Expertise

University of Edinburgh, UK

Cedric Mims

Cedric Mims began as a zoologist, studying under GP Wells and JBS Haldane at University College, London. He then went to the Middlesex Hospital Medical School, London, graduating in 1952. After hospital appointments he spent three years in Uganda studying tropical fevers, and then 16 years in Canberra, Australia, interspersed with two years in the USA. This was followed by a 20-year period in London as Professor of Microbiology at Guy's Hospital Medical School, where his enthusiasm for teaching found its outlet. His entire career has focused on infectious diseases and immunology, and he has produced five books and more than a hundred scientific papers on these subjects. He has four children and nine grandchildren and lives in the Sussex countryside.

Affiliations and Expertise

Guy's Hospital Medical School, UMDS, London, U.K.

John Stephen

Affiliations and Expertise

University of Birmingham, Edgbaston, U.K.


Praise for the previous editions: "This is an outstanding book of high scholarship of much interest to immunologists, microbiologists, pathologists and all those concerned with infectious diseases." -Molecular Medicine Today "A splendidly imaginative book which will become a trusty companion for many of us." - The Lancet "An excellent book which should be read by teachers, students, and research workers." - New Scientist