Mims' Pathogenesis of Infectious Disease

Mims' Pathogenesis of Infectious Disease

5th Edition - September 19, 2000

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  • Authors: Anthony Nash, Cedric Mims, John Stephen
  • eBook ISBN: 9780080538501

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Mims' Pathogenesis of Infectious Disease is the landmark book in the field of infectious disease. The new, revised edition of this work provides a comprehensive, up-to-date description of the mechanisms of microbial infection and the pathogenesis of infectious disease. Presented in a clear, accessible style, it deals in an integrated manner with the spectrum of microorganisms, describing the factors common to all infectious diseases. Molecular biology, pathology, and immunology are brought together to explain the mechanisms for spread, immune response, and recovery.

Key Features

  • Microbial gene sequencing
  • Up-to-date picture of the global burden of infectious diseases
  • Role of bacterial virulence factors in vivo, as contrasted with possibilities based on in vitro evidence
  • Latest data on combination vaccines, the promise of edible vaccines
  • The spread of antibiotic resistance genes among bacteria
  • HIV1 and HIV2; molecular biology, pathogenesis and origin
  • Latest data on tuberculosis - the number one infectious disease worldwide
  • Recent work on papillomaviruses, herpesviruses, BSE and variant CJD
  • Latest data on microbial evasion of immune defences
  • Origin and molecular biology of pandemic influenza
  • Significance of toxins
  • An update on vaccines, prions, immune evasion, microbial ligands and receptors


Undergraduate and graduate students in microbiology and immunology, medical students, and others new to the field of microbiology and infectious diseases.

Table of Contents

  • Preface to the Fifth Edition

    Preface to the Fourth Edition

    Preface to the Third Edition

    Preface to the Second Edition

    Preface to the First Edition

    1 General Principles


    2 Attachment to and Entry of Microorganisms into the Body


    Adhesion/Entry: Some General Considerations

    The Skin

    Respiratory Tract

    Gastro-Intestinal Tract


    Urinogenital Tract


    The Normal Microbial Flora

    Exit of Microorganisms From the Body


    3 Events Occurring Immediately After the Entry of the Microorganism

    Growth in Epithelial Cells

    Intracellular Microorganisms and Spread through the Body

    Subepithelial Invasion

    Nutritional Requirements of Invading Microbes


    4 The Encounter with the Phagocytic Cell and the Microbe's Answers

    Cell Biology of Phagocytosis

    Phagocytosis in Polymorphonuclear Leucocytes

    Phagocytosis in Macrophages

    Microbial Strategy in Relation to Phagocytes

    Growth in the Phagocytic Cell

    Killing the Phagocyte

    Entry into the Host Cell Other than by Phagocytosis

    Consequences of Defects in the Phagocytic Cell



    5 The Spread of Microbes through the Body

    Direct Spread

    Microbial Factors Promoting Spread

    Spread via Lymphatics

    Spread via the Blood

    Spread via Other Pathways


    6 The Immune Response to Infection

    Antibody Response

    T-Cell-Mediated Immune Response

    Natural Killer Cells

    Macrophages, Polymorphs and Mast Cells

    Complement and Related Defense Molecules

    Conclusions Concerning the Immune Response to Microorganisms


    7 Microbial Strategies in Relation to the Immune Response

    Infection Completed before the Adaptive Immune Response Intervenes

    Induction of Immunological Tolerance


    Absence of a Suitable Target for the Immune Response

    Microbial Presence in Bodily Sites Inaccessible to the Immune Response

    Induction of Inappropriate Antibody and T-Cell Responses

    Antibodies Mopped Up by Soluble Microbial Antigens

    Local Interference with Immune Forces

    Reduced Interferon Induction or Responsiveness

    Antigenic Variation

    Microorganisms that Avoid Induction of an Immune Response


    8 Mechanisms of Cell and Tissue Damage

    Infection with no Cell or Tissue Damage

    Direct Damage by Microorganisms

    Microbial Toxins

    Indirect Damage via Inflammation

    Indirect Damage via the Immune Response (Immunopathology)

    Other Indirect Mechanisms of Damage



    9 Recovery from Infection

    Immunological Factors in Recovery




    Multimechanistic Recovery: An Example


    Tissue Repair

    Resistance to Re-Infection


    10 Failure to Eliminate Microbe


    Persistent Infection with Shedding

    Epidemiological Significance of Persistent Infection with Shedding

    Persistent Infection without Shedding

    Significance for the Individual of Persistent Infections



    11 Host and Microbial Factors Influencing


    Genetic Factors in the Microorganism

    Genetic Factors in the Host

    Hormonal Factors and Stress

    Other Factors


    12 Vaccines and How they Work


    General Principles

    Complications and Side Effects of Vaccines

    The Development of New Vaccines







Product details

  • No. of pages: 464
  • Language: English
  • Copyright: © Academic Press 2000
  • Published: September 19, 2000
  • Imprint: Academic Press
  • eBook ISBN: 9780080538501

About the Authors

Anthony Nash

Anthony Nash
Tony Nash is Emeritus Professor of Infectious Diseases at the University of Edinburgh. He has had a distinguished career i the field of viral pathogenesis in which he has over a 150 publications. He is a Fellow of the Royal Society of Edinburgh and of the Academy of medical sciences of the UK.

Affiliations and Expertise

University of Edinburgh, UK

Cedric Mims

Cedric Mims began as a zoologist, studying under GP Wells and JBS Haldane at University College, London. He then went to the Middlesex Hospital Medical School, London, graduating in 1952. After hospital appointments he spent three years in Uganda studying tropical fevers, and then 16 years in Canberra, Australia, interspersed with two years in the USA. This was followed by a 20-year period in London as Professor of Microbiology at Guy's Hospital Medical School, where his enthusiasm for teaching found its outlet. His entire career has focused on infectious diseases and immunology, and he has produced five books and more than a hundred scientific papers on these subjects. He has four children and nine grandchildren and lives in the Sussex countryside.

Affiliations and Expertise

Guy's Hospital Medical School, UMDS, London, U.K.

John Stephen

Affiliations and Expertise

University of Birmingham, Edgbaston, U.K.

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