
Mims' Pathogenesis of Infectious Disease
Description
Key Features
- Describes the origin and molecular biology of pandemic influenza, HIV1, and HIV2 as well as the recent work on papillomaviruses, herpesviruses, BSE, and variant CJD
- Contains the latest data on tuberculosis, microbial evasion of immune defenses, and the spread of antibiotic resistance genes among bacteria
- Provides an update on vaccines, prions, immune evasion, and microbial ligands and receptors
- Gives an up-to-date picture of the global burden of infectious diseases
Readership
Table of Contents
- Preface
- Chapter 1. General Principles
- Bibliography
- Chapter 2. Attachment to and Entry of Microorganisms into the Body
- Introduction
- Adhesion/Entry: Some General Considerations
- The Skin
- Respiratory Tract
- Gastrointestinal Tract
- Oropharynx
- Urinogenital Tract
- Conjunctiva
- The Normal Microbiota
- Exit of Microorganisms from the Body
- Bibliography
- Chapter 3. Early Stages of Infection After Pathogen Entry
- Growth in Epithelial Cells
- Intracellular Microorganisms and Spread Through the Body
- Subepithelial Invasion
- Nutritional Requirements of Invading Microbes
- Bibliography
- Chapter 4. Encounter of Microbes with Phagocytic Cells
- Cell Biology of Phagocytosis
- Phagocytosis in Polymorphonuclear Leucocytes
- Phagocytosis in Macrophages
- Microbial Strategy in Relation to Phagocytes
- Growth in the Phagocytic Cell
- Killing the Phagocyte
- Entry into the Host Cell Other Than by Phagocytosis
- Consequences of Defects in the Phagocytic Cell
- Summary
- Bibliography
- Chapter 5. The Spread of Microbes Through the Body
- Direct Spread
- Microbial Factors Promoting Spread
- Spread Via Lymphatics
- Spread Via the Blood
- Spread Via Other Pathways
- Bibliography
- Chapter 6. The Immune Response to Infection
- Antibody Response
- T-Cell-Mediated Immune Response
- NK Cells
- Macrophages, Neutrophils and Mast Cells
- Complement and Related Defence Molecules
- Conclusions Concerning the Immune Response to Microorganisms
- Bibliography
- Chapter 7. Microbial Strategies in Relation to the Immune Response
- Induction of Immunological Tolerance
- Immunosuppression
- Absence of a Suitable Target for the Immune Response
- Microbial Presence in Bodily Sites Inaccessible to the Immune Response
- Induction of Inappropriate Antibody and T-Cell Responses
- Antibodies Mopped up by Soluble Microbial Antigens
- Local Interference with Immune Forces
- Reduced Interferon Induction or Responsiveness
- Antigenic Variation
- Bibliography
- Chapter 8. Mechanisms of Cell and Tissue Damage
- Infection with No Cell or Tissue Damage
- Direct Damage by Microorganisms
- Microbial Toxins
- Indirect Damage via Inflammation
- Indirect Damage via the Immune Response (Immunopathology)
- Other Indirect Mechanisms of Damage
- Diarrhoea
- Bibliography
- Chapter 9. Recovery from Infection
- Immunological Factors in Recovery
- Inflammation
- Complement
- Interferons
- Multimechanistic Recovery: An Example
- Temperature
- Tissue Repair
- Resistance to Re-Infection
- Bibliography
- Chapter 10. Failure to Eliminate Microbe
- Latency
- Persistent Infection with Shedding
- Epidemiological Significance of Persistent Infection with Shedding
- Persistent Infection Without Shedding
- Significance for the Individual of Persistent Infections
- Conclusions
- Bibliography
- Chapter 11. Host and Microbial Factors Influencing Susceptibility
- Genetic Factors in the Microorganism
- Genetic Factors in the Host
- Stress and Hormonal Factors
- Other Factors
- Bibliography
- Chapter 12. Vaccines and How They Work
- Introduction
- General Principles
- Complications and Side Effects of Vaccines
- Reverse Vaccinology
- Bibliography
- Appendix
- Conclusions
- Glossary
- Index
Product details
- No. of pages: 364
- Language: English
- Copyright: © Academic Press 2015
- Published: January 21, 2015
- Imprint: Academic Press
- Paperback ISBN: 9780123971883
- eBook ISBN: 9780123977816
About the Authors
Anthony Nash

Affiliations and Expertise
Robert Dalziel

Dr. Dalziel’s research interests focus on the mechanism of virus pathogenesis with a particular interest in herpesviruses. He has almost 30 years of experience in teaching undergraduate veterinary science and medical students and has designed and developed a number of undergraduate courses. He has supervised over 20 Graduate students and has served as a member of the UK Government Advisory Committee on Genetic Manipulation (ACGM). He is also Editor in Chief of Veterinary Research Communications.
Affiliations and Expertise
J. Fitzgerald

Affiliations and Expertise
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