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Mims' Pathogenesis of Infectious Disease
6th Edition - January 21, 2015
Authors: Anthony A. Nash, Robert G. Dalziel, J. Ross Fitzgerald
Language: English
Paperback ISBN:9780123971883
9 7 8 - 0 - 1 2 - 3 9 7 1 8 8 - 3
eBook ISBN:9780123977816
9 7 8 - 0 - 1 2 - 3 9 7 7 8 1 - 6
Mims' Pathogenesis of Infectious Disease is the landmark book in the field of infectious disease. The new, revised edition of this work provides a comprehensive, up-to…Read more
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Mims' Pathogenesis of Infectious Disease is the landmark book in the field of infectious disease. The new, revised edition of this work provides a comprehensive, up-to-date description of the mechanisms of microbial infection and the pathogenesis of infectious disease. Presented in a clear, accessible style, it deals in an integrated manner with the spectrum of microorganisms, describing the factors common to all infectious diseases. Molecular biology, pathology, and immunology are brought together to explain the mechanisms for spread, immune response, and recovery.
Describes the origin and molecular biology of pandemic influenza, HIV1, and HIV2 as well as the recent work on papillomaviruses, herpesviruses, BSE, and variant CJD
Contains the latest data on tuberculosis, microbial evasion of immune defenses, and the spread of antibiotic resistance genes among bacteria
Provides an update on vaccines, prions, immune evasion, and microbial ligands and receptors
Gives an up-to-date picture of the global burden of infectious diseases
Undergraduate and graduate students in microbiology and immunology, medical students, and others new to the field of microbiology and infectious diseases
Preface
Chapter 1. General Principles
Bibliography
Chapter 2. Attachment to and Entry of Microorganisms into the Body
Introduction
Adhesion/Entry: Some General Considerations
The Skin
Respiratory Tract
Gastrointestinal Tract
Oropharynx
Urinogenital Tract
Conjunctiva
The Normal Microbiota
Exit of Microorganisms from the Body
Bibliography
Chapter 3. Early Stages of Infection After Pathogen Entry
Growth in Epithelial Cells
Intracellular Microorganisms and Spread Through the Body
Subepithelial Invasion
Nutritional Requirements of Invading Microbes
Bibliography
Chapter 4. Encounter of Microbes with Phagocytic Cells
Cell Biology of Phagocytosis
Phagocytosis in Polymorphonuclear Leucocytes
Phagocytosis in Macrophages
Microbial Strategy in Relation to Phagocytes
Growth in the Phagocytic Cell
Killing the Phagocyte
Entry into the Host Cell Other Than by Phagocytosis
Consequences of Defects in the Phagocytic Cell
Summary
Bibliography
Chapter 5. The Spread of Microbes Through the Body
Direct Spread
Microbial Factors Promoting Spread
Spread Via Lymphatics
Spread Via the Blood
Spread Via Other Pathways
Bibliography
Chapter 6. The Immune Response to Infection
Antibody Response
T-Cell-Mediated Immune Response
NK Cells
Macrophages, Neutrophils and Mast Cells
Complement and Related Defence Molecules
Conclusions Concerning the Immune Response to Microorganisms
Bibliography
Chapter 7. Microbial Strategies in Relation to the Immune Response
Induction of Immunological Tolerance
Immunosuppression
Absence of a Suitable Target for the Immune Response
Microbial Presence in Bodily Sites Inaccessible to the Immune Response
Induction of Inappropriate Antibody and T-Cell Responses
Antibodies Mopped up by Soluble Microbial Antigens
Local Interference with Immune Forces
Reduced Interferon Induction or Responsiveness
Antigenic Variation
Bibliography
Chapter 8. Mechanisms of Cell and Tissue Damage
Infection with No Cell or Tissue Damage
Direct Damage by Microorganisms
Microbial Toxins
Indirect Damage via Inflammation
Indirect Damage via the Immune Response (Immunopathology)
Other Indirect Mechanisms of Damage
Diarrhoea
Bibliography
Chapter 9. Recovery from Infection
Immunological Factors in Recovery
Inflammation
Complement
Interferons
Multimechanistic Recovery: An Example
Temperature
Tissue Repair
Resistance to Re-Infection
Bibliography
Chapter 10. Failure to Eliminate Microbe
Latency
Persistent Infection with Shedding
Epidemiological Significance of Persistent Infection with Shedding
Persistent Infection Without Shedding
Significance for the Individual of Persistent Infections
Conclusions
Bibliography
Chapter 11. Host and Microbial Factors Influencing Susceptibility
Genetic Factors in the Microorganism
Genetic Factors in the Host
Stress and Hormonal Factors
Other Factors
Bibliography
Chapter 12. Vaccines and How They Work
Introduction
General Principles
Complications and Side Effects of Vaccines
Reverse Vaccinology
Bibliography
Appendix
Conclusions
Glossary
Index
No. of pages: 364
Language: English
Edition: 6
Published: January 21, 2015
Imprint: Academic Press
Paperback ISBN: 9780123971883
eBook ISBN: 9780123977816
AN
Anthony A. Nash
Tony Nash is Emeritus Professor of Infectious Diseases at the University of Edinburgh. He has had a distinguished career i the field of viral pathogenesis in which he has over a 150 publications. He is a Fellow of the Royal Society of Edinburgh and of the Academy of medical sciences of the UK.
Affiliations and expertise
University of Edinburgh, UK
RD
Robert G. Dalziel
Dr. Dalziel gained his BSc (Honours) in Biochemistry from the University of Glasgow in 1980. He then carried out his PhD studies on protein/DNA interactions in HSV-1 infected cells at the MRC Institute for Virology in Glasgow, graduating in 1984. He carried out post-doctoral research at the Scripps Research Institute, La Jolla CA, and in 1987 accepted a faculty position at the University of Edinburgh where he is now a senior lecturer and group leader in the Roslin Institute, Royal (Dick) School of Veterinary Studies.
Dr. Dalziel’s research interests focus on the mechanism of virus pathogenesis with a particular interest in herpesviruses. He has almost 30 years of experience in teaching undergraduate veterinary science and medical students and has designed and developed a number of undergraduate courses. He has supervised over 20 Graduate students and has served as a member of the UK Government Advisory Committee on Genetic Manipulation (ACGM). He is also Editor in Chief of Veterinary Research Communications.
Affiliations and expertise
University of Edinburgh, UK
JF
J. Ross Fitzgerald
Dr. J. Ross Fitzgerald is the principle investigator for the Laboratory for Bacterial Evolution and Pathogenesis, Centre for Infectious Diseases based at the College of Medicine and Veterinary Medicine, University of Edinburgh. The laboratory is focused on the use of genomic and molecular tools to examine the evolution and pathogenesis of clinically important species of Staphylococci. Dr. Fitzgerald has published numerous papers in peer-reviewed research journals.
Affiliations and expertise
University of Edinburgh, UK
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