Microsomes, Drug Oxidations and Chemical Carcinogenesis V2

Microsomes, Drug Oxidations and Chemical Carcinogenesis V2

1st Edition - January 1, 1980

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  • Editor: Minor Coon
  • eBook ISBN: 9780323143875

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Microsomes, Drug Oxidations, and Chemical Carcinogenesis, Volume II, documents the proceedings of the 4th International Symposium on Microsomes and Drug Oxidations held in Ann Arbor, July 1979. The symposium reviewed progress in the understanding of scientific and biomedical problems from a biochemical, biophysical, pharmacological, and toxicological perspective. Volume I contained 117 contributions made by researchers at the symposium, which were organized into three sections (Sections I-III). This second volume contains 122 contributions, divided into four sections (Sections IV-VII). The papers on Section IV examine the metabolic fate of oxygenated compounds. Section V provides studies on microsomal enzymes and lipid metabolism. Section VI includes papers on microsomal enzymes and toxicity of foreign compounds. Section VII covers microsomal enzymes and chemical mutagenesis and carcinogenesis. This book seeks to aid future progress in understanding the complexities of metabolic transformations by these versatile enzyme systems that act on physiologically important lipids as well as on a wide array of foreign substances, including drugs, anesthetics, industrial chemicals, food additives, pesticides, carcinogens, and nonnutrient dietary chemicals.

Table of Contents

  • Section IV Metabolic Fate of Oxygenated Compounds

    Rate-Limiting Factors in Xenobiotic Metabolism by Cytochome P-450, Sulphotransferase, and Glucuronyl Transferase

    Epoxide Hydratase

    Kinetic Studies on Mechanism and Substrate Specificity of the Microsomal Flavin-Containing Monooxygenase

    Epoxide Hydratase and its Membrane Environment

    Interindividual Variations of Epoxide Hydratase Activity in Human Liver and Lung Biopsies, Lymphocytes and Fibroblast Cultures

    Extramicrosomal Epoxide Hydration

    Metabolism of Benzo(a)pyrene by Liposomes containing Purified Microsomal Drug-Metabolizing Enzymes

    Comparison of Glutathione S-Transferases from Rat Tissues with the Activity in Human Placenta

    Formation, Metabolism, and Excretion of Conjugates of Paracetamol

    Subcellular Localization of Glutathione S-Transferase Activity in Rat Liver

    Biliary Metabolites of Benzo(a)pyrene 4,5-Oxide in the Rat

    Hepatic and Extrahepatic Glutathione S-Transferase Activities in Vitamin A Deficiency

    Pulmonary Metabolism and Excretion of Arene Oxides

    Metabolism of Arylamines: Evidence for Common Genetic Control of Arylhydroxamic Acid Acyltransferase (AHAT) and Genetically Polymorphic N-Acetyltransferase (NAT) of Rabbit Liver

    Partial Purification of Glutathione (GSH)-S-Aryl- and Epodixe Transferase(s) of Trypanosoma Cruzi

    Purification and Properties of UDP-Glucuronyltransferase from Rabbit Liver Microsomes

    Section V Microsomal Enzymes and Lipid Metabolism

    Cholesterol 7α-Hydroxylase in Rat Liver Microsomes—Characteristics, Solubilization, Resolution, and Substrate Specificity

    Laurate Hydroxylation and Drug Metabolism in Pig Liver and Kidney Microsomes and in Reconstituted Systems from Pig Liver and Kidney

    Product Specificity and Regulation of Two Laurate Hydroxylases in Higher Plants

    Effect of Phenobarbital on Triglyceride Metabolism in the Rat

    ω- and (ω-1)-Hydroxylation of Fatty Acids in Rabbit Intestinal Mucosa Microsomes

    The Role of Cytochrome b5 in the Liver Microsomal Elongation of Fatty Acids

    Evidence for Different Hepatic Monooxygenases in (ω-1)- and ω-Hydroxylation of Prostaglandins

    Effect of Inducing Agents and Cytochrome P-450 Inhibitors on Laurate Hydroxylase Activities in Rat Liver Microsomes

    Steroid Hydroxylases in Liver Microsomes and Mitochondria

    C-21 and 6α-Hydroxylation of Progesterone by Solubilized Rabbit Hepatic Microsomal Fractions: Nonobligatory Requirement for Cytochrome P-450

    Microsomal Lipid Peroxidation: Catalysis, Effects, and Inhibition by Cytosolic Protein

    Cytochrome P-450-Containing Monooxygenase System of Yeast Microsomes, Properties and Role in Sterol Biosynthesis

    Studies on Liver and Kidney Drug and Lauric Acid Monooxygenases in Both Microsomal and Reconstituted Systems

    Lipid Peroxidation induced by Glutathione Depletion

    Metabolism of Juvenile Hormone (JH) Mimics by a Reconstituted Rat Liver Cytochrome P-450 Preparation

    Section VI Microsomal Enzymes and Toxicity of Foreign Compounds

    An overview of the Role of Microsomal Enzymes in the Formation of Toxic Metabolites

    Microsomal Enzymes and the Toxicity of Thiono-Sulphur Compounds

    The Ah Locus, Genetic Differences in Toxic and Tumorigenic Response to Foreign Compounds

    Comparison of Caffeine Metabolism by Perfused Rat Liver and Isolated Microsomes

    Rhythmic Response of the Hepatic 2- and 4-Biphenyl Hydroxylase in Rats to Drugs Upon Intermittent Treatment

    Functional Changes of Hepatic Endoplasmic Reticulum by Adverse Drug Treatment

    A Procedure for Isolation of Rabbit Pulmonary Epithelial Cells for Study of Foreign Compound Metabolism

    The Formation of Amphetamine Metabolic Intermediate Complexes with CytoChrome P-450 in Microsomes and Intact Tissues

    Comparative Aspects of Hepatic Monooxygenase Induction in Rat and Rainbow Trout by Several PCB Isomers

    Genetic and Environmental Influences on Tolbutamide Metabolism

    Ethchlorvynol: Potential of Metabolites for Adverse Effects in Man

    Irreversible Binding of 6-Thiopurine to Rat Hepatic Microsomal Proteins In Vitro and In Vivo

    Activation of a Proestrogen—Methoxychlor (DDT Analog)—by Hepatic Monooxygenase

    Effects of Some Flame Retardants on the Liver Microsomal Enzyme Systems

    The Development of Hepatic Mixed-Function Oxidases—Warfarin Metabolism as a Probe

    Loss and Recovery of Hepatic Monooxygenase Activities After the Administration of Allylisopropylacetamide (AIA) to Mice

    Metabolism of Fluroxene and Analogous Fluorinated Ether Anesthetics by Highly Purified Cytochromes P-450 and the Associated Enzyme Destruction

    Evaluation of 4-Formylaminoantipyrine and other N-Demethylated Products of Aminopyrine in Hepatic Microsomes by HPLC

    The Effect of Selenium and Vitamin E Deficiency on the Toxicity of Nitrofurantoin in the Chick

    The Reductive Metabolism of Carbon Tetrachloride in Reconstituted Monooxygenase Systems

    Oxidative Bioactivation of Haloforms into Hepatotoxins

    Effects of Isoniazid Metabolites on the Rate of Hepatic Microsomal Defluorination of Volatile Fluorinated Ether Anesthetics

    Effects of Indole Derivatives on Monooxygenase Activity in Rabbit Liver Microsomes

    Coincident Induction of Cytochrome P-450 and Phenol Red Conjugation in Cultured Chick Embryo Hepatocytes: Effects of Cobaltous and Manganous Ions

    Benzene Metabolism and Toxicity in CD-1, C57/B6, and DBA/2N Mice

    Hepatotoxicity Due to Tetrachlorodibenzo(p)dioxin Depends Upon AHH Responsiveness and Nonhemoprotein Iron

    The Mechanism of Cytochrome P-450-Mediated Cytotoxicity Studied with Isolated Hepatocytes Exposed to Bromobenzene

    The Influence of the Nutritional State of Rates of p-Nitroanisole O-Demethylation and p-Nitrophenol Conjugation in Perfused Rat Livers

    Acute Decline of Hepatic Microsomal Monooxygenase Activity and Other Properties by Morphine Sulfate

    Substituent Effects on Toxicity and Covalent Binding of Bromobenzene Derivatives

    Hepatic Microsomal Epoxidation of Bromobenzene to Phenols and its Toxicological Implication

    Toxicity of 2-Chlorobenzylidene Malononitrile and Hepatic Microsomal Mixed Function Oxidase System

    Alteration of Microsomal Monooxygenase Activities by Cobalt Pretreatment of Mice

    Characteristics of the Microsomal and Mitochondrial Deamination of Benzylamine

    Oxidation of N-Hydroxy-Amphetamine and -Phentermine by Active Oxygen

    N-Methylcarbazole Metabolism: A Probe for Characterizing the Multiple Forms of Cytochrome P-450

    Increased Activity of the Pentose Pathway after Administration of trans-Stilbene Oxide

    Interactions Between Energy Metabolism and Mixed-Function Oxidation in Perfused Rat Liver

    Evidence for More Than One Form of Cytochrome P-450 in Hepatic Microsomal Fractions of Human Liver Samples

    The In Vitro Metabolism of 3-Acetylpyridine, 3-Acetylpyridine-N-Oxide, and 1-(-3-Pyridyl)-Ethanol

    Studies on Sex Differences in the O-Dealkylation Activities of 7-Hydroxycoumarin O-Alkyl Derivatives in Liver Microsomes of Rats

    Augmentation by Hematin of Rates of Benzo(a)pyrene Hydroxylation: the Possible involvement of Cytochrome P-450

    Multiplicity of NADPH- and NADH-Supported N- and O-Dealkylating Systems of Hepatic Microsomes

    4-Chlorobiphenyl Hydroxylase: a Monooxygenase Preferentially Induced by 3-Methlcholanthrene

    NADH- and NADPH-Dependent Reduction of Indicine N-Oxide by Microsomal Cytochrome P-450

    Metabolism and Irreversible Binding of Phencyclidine by Rabbit Lung and Liver Microsomes

    Cleavage of Vicinal Diols by Liver Microsomes

    Characterization of the Form of P-450 Induced by Methylenedioxy Compounds in Rats and Mice

    Interaction of the Enzyme Inducer, HOE 17,879, with Microsomal Enzyme Systems

    Relation Between In Vitro Alteration by Allyl Compounds and Forms of Cytochrome P-450

    The Rapid Activation of P-450-Mediated Metabolism by Corticosteroids

    Metabolism In Vitro of Capsaicin, a Pungent Principle of Red Pepper, with Rat Liver Homogenates

    Section VII Microsomal Enzymes and Chemical Mutagenesis and Carcinogenesis

    Metabolism of Benzo(a)pyrene and Oncogenic Transformation of C3H/10T1/2 Mouse Embryo Fibroblasts

    An Overview of the Salmonella Mutagenicity Test

    Bay-Region Activation of Polycyclic Aromatic Hydrocarbons to Ultimate Mutagens and Carcinogens

    Biotransformation of Benzo(a)pyrene to DNA-Binding Products by Isolated Hepatocytes

    Catalytic Activity and Stereospecificity of Phenobarbital-Inducible and 5,6,-Benzoflavone-Inducible Isozymes of Liver Microsomal Cytochrome P-450 in the Oxygenation of Benzo(a)pyrene and trans-7,8-Dihydroxy-7,8-Dihydrobenzo(a)pyrene

    Metabolism of Nitrosamines: an Overview

    Species Differences in Microsomal Activation of Mutagens and Carcinogens, with Special Reference to New Potent Mutagens from Pyrolysates of Amino Acids and Proteins

    Microsomes and Drug Oxidations: Perspectives and Challenges

    Catalytic Properties of Microsomal and Purified Epoxide Hydrolase Toward K-Region Arene Oxides

    Drug-Metabolizing Systems in the Liver of the Northern Pike, Esox Lucius

    Dietary Protein and Mixed Function Oxidase Activity

    The Metabolism of 1,2-Disubstituted Hydrazines in Isolated Hepatocytes

    Mutagenicity and Metabolism of Cyclopenta(cd)pyrene

    Some Characteristics of the Drug-Metabolizing Enzymes in Isolated Hepatic Nuclei

    Microsomal Metabolism of Diallylnitrosamine

    Mutants of Cultured Hepatoma Cells Deficient in Aryl Hydrocarbon Hydroxylase

    Qualitative and Quantitative Studies of DNA-Binding Metabolites of Benzo(a)pyrene by Fluorescence Spectroscopy

    Use of the Ames Assay for Studying Factors Affecting the Activation of 2-Aminoanthracene to Mutagenic Metabolites

    Cytochrome P-450 Form 4, a Major Determinant of 2-Aminoanthracene Mutagenesis

    Rat Hepatocytes of in Primary Monolayer Culture: a Tool for Investigating the Regulation of Carcinogen Metabolism

    The Metabolism of 3- and 9-Hydroxybenzo(a)pyrene by Rat Liver Microsomal Fractions

    Effect of Chronic Ethanol Consumption on Microsomal Enzymes: Potential Relationship to Chemical Mutagenesis and Carcinogenesis

    Characterization of the Cytochrome P-450-Containing Mixed Function Oxidase System of Rat Colon

    Induction of N- and C-Hydroxylations of 2-Acetylaminofluorene in Rat Hyperplastic Liver Nodules and Hepatomas

    Multiple Activation Pathways of 7,12-Dimethylbenz(a)anthracene

    Influence of Modifiers of MFO Activity on the In Vitro Metabolism of Cyclic Nitrosamines

    Autocatalyzed Covalent Binding of 3H(-)t-7,8-Diol Benzo(a)pyrene to Mixed-Function Oxidase Enzymes and DNA: the Role of Epoxide Hydratase

    Regulation of DNA Modification by Selective Conjugation of Benzo(a)pyrene Metabolites

    Metabolism of Benzo(a)pyrene in Little Skate Mixed-Function Oxidase Systems

    Inducibility of the Metabolism of Benzo(a)pyrene by Polychlorinated Biphenyls (PCBs) in Liver and Lung Microsomal Preparations from Rats and Rabbits

    Covalent Binding of Vinyl Chloride Metabolites In Vitro: Roles of Cytochrome P-450, NADPH-Cytochrome P-450 Reductase, Epoxide Hydratase, and Alcohol Dehydrogenase

    Evidence for Inhibitory Complexed Formed with Cytochrome P-450 and a Metabolite of 1,1-Disubstituted Hydrazines

    Ovarian Aryl Hydrocarbon Hydroxylase Activity and Oocyte Destruction

    Binding of Reactive Metabolites of Aromatic Hydrocarbons to Specific Microsomal Proteins

    Secondary Oxygenation of the Carcinogen 2-AcetylaminoFluorene (= 2-AAF) In Vitro and In Vivo

    Metabolism of 7,12-Dimethylbenz(a)anthracene in Rat Adrenals

    The Influence of Organic Solvents on Cytochrome P-450-Mediated Metabolism of Biphenyl and Benzo(a)pyrene

    Effects of Estrone, Estradiol, and Estriol Pretreatment on Hepatic, Lung, and Intestinal Aryl Hydrocarbon Hydroxylase Activities in Female Rats

    Formation of Benzo(a)pyrene Metabolites in Isolated Intestinal Sacs

    Index for Volumes I and II

Product details

  • No. of pages: 655
  • Language: English
  • Copyright: © Academic Press 1980
  • Published: January 1, 1980
  • Imprint: Academic Press
  • eBook ISBN: 9780323143875

About the Editor

Minor Coon

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