Microsomes, Drug Oxidations and Chemical Carcinogenesis V1

1st Edition - January 28, 1980
Editor: Minor Coon
Language: English
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 1 4 4 0 9 - 4

Microsomes, Drug Oxidations, and Chemical Carcinogenesis, Volume I, documents the proceedings of the 4th International Symposium on Microsomes and Drug Oxidations held in Ann… Read more

Microsomes, Drug Oxidations and Chemical Carcinogenesis V1

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Microsomes, Drug Oxidations, and Chemical Carcinogenesis, Volume I, documents the proceedings of the 4th International Symposium on Microsomes and Drug Oxidations held in Ann Arbor, July 1979. The symposium reviewed progress in the understanding of scientific and biomedical problems from a biochemical, biophysical, pharmacological, and toxicological perspective. The book contains 117 contributions made by researchers at the symposium, which are organized into three sections. The papers in Section I focus on the chemical and physical characteristics of cytochrome P-450. Section II examines the mechanisms of action of cytochrome P-450 and related enzymes. The studies in Section III deal with the influence of membrane structure and protein synthesis on electron transfer components. This book seeks to aid future progress in understanding the complexities of metabolic transformations by these versatile enzyme systems that act on physiologically important lipids as well as on a wide array of foreign substances, including drugs, anesthetics, industrial chemicals, food additives, pesticides, carcinogens, and nonnutrient dietary chemicals.

Senior Authors for Volumes I and II

Preface

Acknowledgments

Section I Chemical and Physical Characterization of Cytochrome P-450

Enzymatic Activation of Molecular Oxygen

Characterization of a Steroid-Hydroxylating Cytochrome P-450 of Bacterial Origin

Purification and Some Properties of Cytochrome P-450 with High Affinity for Cytochrome b5

Second Derivative Spectroscopic Studies of the Essential Components of the Liver Microsomal Monooxygenation System

Characterization of Three Forms of Rat Hepatic Cytochrome P-450: Evidence for Separate Gene Products

On the Stimulatory Role of Phosphatidylcholine in a Cytochrome P-450-Containing Reconstituted Hydroxylation System

Thermodynamic and Kinetic Properties of the Adrenocortical Mitochondrial Cytochrome P-450 which Converts Cholesterol into Pregenolone

Structural Organization of Cytochrome P-450scc from Adrenal Cortex

Sequence Determination of the Pseudomonas Putida Cytochrome P-450: Isolation and Partial Sequences of the Cysteine Peptides

Interactions of Electron Transport Components of the Microsomal Monooxygenase System

Cross-Linking Studies of Monooxygenase Enzymes

Monooxygenase Activities of Partially Purified Cytochromes P-450 from Human Liver Microsomes

Use of Methylayapanine as a Substrate for Microsomal O-Demethylase

Purification of Human and Rat Cytochromes P-450 and P-450 Reductase and their Reconstitution into Phospholipid Vesicles

The Influence of Fatty Acids and Membrane Lipids on the Spin State of Purified Cytochrome P-450

The Interaction of 1-Anilino-8-Naphthalene Sulfonate with Cytochrome P-450

Immunological Cross-Reactivity of Rat Liver and Human Cytochromes P-450

Hydrodynamic Characterization of Liver Microsomal Cytochrome P-450

Can Proton NMR of Water Unambiguously Measure the Water-Iron Interaction in Hepatic Microsomal Cytochrome P-450?

Influence of Substrates of Hepatic Mixed Function Oxidases on Spin Equilibrium of Cytochrome P-450

Contrasting Properties of Microsomal Cytochrome P-450: Characterization of a Constitutive Form of the Cytochrome

Warfarin Metabolism—a Probe of Purified Rat Liver Cytochromes P-450

Estimation of High-Spin Cytochrome P-450 in Microsomes at Room Temperature from the Absolute Oxidized Spectrum Obtained by the Linoleic Acid Hydroperoxide (LAHP) Deletion Method

Structural Gene Products of the Murine Ah Locus. Immunochemical Characterization of Two Forms of P-450 Induced by Polycyclic Aromatic Compounds

Characterization of Acetanilide-P-450lm Interactions: Implications Regarding Substrate Specificity

Effect of Linoleic Acid Hydroperoxide on High and Low Spin Iron in Microsomal Cytochrome P-450

Properties of Liver Microsomal Cytochrome P-450 from Rats Treated with Isosafrole

Characterization of Purified Forms of Rabbit Pulmonary Cytochrome P-450 and Comparison with the Hepatic Cytochrome P-450 Induced by Phenobarbital

Spin States and Redox Potentials of Hepatic Cytochrome P-450

Immunochemical Quantitation of Three Forms of Hepatic Cytochrome P-450 in Rats: Effects of Age and Induction

1H FT NMR Studies of the Effects of Acetanilide and Imidazole on the Solvation Sphere of the Heme Iron Atom in Cytochromes P-450lm2, P-450lm4, and b5

Ligand Binding to Cytochrome P-450cam: Characteristics of the Reduced Species

Studies on the Site of Fluorescamine Inhibition of Cytochrome P-450-Mediated Reactions

Purification of Rabbit Pulmonary and Hepatic Cytochrome P-450 by Hydrophobic Column Chromatography

Effects of Phospholipids on the Spin-State Transition of Cytochrome P-450

Purification and Characterization of Steroid-Metabolizing Cytochrome P-450 Dependent Mixed Function Oxidase Systems from Bovine Adrenocortical Microsomes

A Comparative Study on the Reconstitution of the Hepatic and Pulmonary Microsomal Aniline 4-Hydroxylase Activities from Solubilized Components in the Lamb

Comparison of Plant and Hepatic Cytochrome P-450-Dependent Monoterpene Monooxygenases

Characterization of a Reconstituted Cytochrome P-450 Enzyme System Mediating Tertiary Amine N-Oxidation

Characterization and Reconstitution of Components of the Hepatic Mitochondrial Cytochrome P-450-Linked Mixed Function Oxidase

Isolation of Human Placental Cytochrome P-450 and its Mechanism of Action of Androgen Aromatization

Hydroperoxysterols as a Probe for the Heme Pocket of Cytochrome P-450scc

Section II Mechanism of Action of Cytochrome P-450 and Related Enzymes

Probes of Cytochrome P-450 Structure

Resolution of Multiple Equilibria in Binding of Small Molecules to Cytochrome P-450lm

On the Mechanism of Oxygen Insertion Catalyzed by Cytochrome P-450. Hydroxylation with Partial Allylic Rearrangement

The Nature of the Activated Oxygen Involved in the Hydroxylation Reactions Catalyzed by Cytochrome P-450 from a Study of its Peroxidase Properties

Structure and Reactivity of Peroxidase Higher Oxidation States

Studies on FMN-Depleted and Reconstituted NADPH-Cytochrome c (P-450) Reductase

Reduction of Microsomal Haemoproteins by Superoxide Radical Generated by The NADPH-Specific Flavoprotein

A Kinetic Investigation of Liver Microsomal Mixed Function Amine Oxidase

Spectral Intermediates Observed in the Cumene Hydroperoxide-Dependent Hydroxylation of Toluene Catalyzed by P-450lm2

The Production of Hydroxyl Radicals by Rat Liver Microsomes

Effect of Substrate Lipophilicity on the N-Dealkylation of 3-0-Alkyl Morphine Analogs

Inactivation of NADPH-Cytochrome P-450 (c) Reductase by 2,3-Butanedione and Phenylglyoxal. Evidence for an Essential Arginine

Detection of Free Radical Species Derived from Cumene Hydroperoxide in Model Hemeprotein Systems and in Rat Liver Microsomes by Spin-Trapping Techniques

Mechanism of the Inactivation of Rat Liver Cytochrome P-450 by Parathion

Inactivation of Cytochrome P-450 Enzymes by Cyclopropylamines

Stoichiometry of mixed Function Oxidase-Dependent Hydroxylation of Hexobarbital

Substrate and Oxygen Activation During Hexobarbital Metabolism

Kinetic Investigation of the Reduction of Cytochrome P-450cam by Sodium Dithionite

Benzphetamine-Induced H2O2 Generation

Inhibition of NADPH-Cytochrome c Reductase by Purine Nucleotides and Selected Metabolites

Characterization of the N-Demethylation Reactions Catalyzed by Chloroperoxidase

Phenazine Methosulfate as a “Bypass Reagent” in the Reduction of Microsomal Cytochromes

Oxyferro Intermediate of P-450 (LM2): Spectral Properties and Autoxidation Kinetics

Kinetic Isotope Effects in Cytochrome P-450-Catalyzed Oxidation Reactions. I. Substrate-Cytochrome P-450 Interactions

Camphor-Derived Affinity Reagents for Specific Labeling of Cytochrome P-450cam: Synthesis and Application of Isobornyl Mercaptan

Loss of Methylcyclohexyl Stereospecificity During Cytochrome P-450-Dependent Monooxygenation

Inhibition of Hexobarbital-Induced Microsomal H2O2 Production by Metyrapone

Cytochrome P-450 Reduction by FMN-Depleted Rat Liver NADPH-Cytochrome P-450 Reductase Reconstituted with Artificial Flavins

Kinetic Study of Cytochrome P-450lm4 Reduction in a Reconstituted Liver Microsomal Enzyme System

Studies on the Association of P-450lm2 with NADPH-Cytochrome P-450 Reductase and with Tryptic Peptides Derived from the Reductase

Tetrahedral Intermediates in Cytochrome P-450 Hydroxylations

The Mechanism of Compound I Formation as Deduced Using Artifical Peroxidases

On the Role of Perhydroxyl Radical as an Oxidizing Agent

Comparison of the Interaction of Cumene Hydroperoxide and Hydrogen Peroxide with Liver Microsomal Cytochromes

Reaction Mechanism of Hepatic NADPH-Cytochrome P-450 Reductase

Mechanism of Ligand Binding of Safrole to Cytochrome P-450

The Effects of Antioxidants on Hemoprotein Function

Hydroxyl Radical Formation during P-450 Function and Benzopyrene Hydroxylation

Inactivation of Cytochrome P-450 by Suicide Substrates. Partial Structure of the Resulting Prosthetic-Heme Adducts

The Substrate-Cytochrome P-450 Binding Reaction at Physiologic Temperature in Bovine Adrenocortical Microsomes: the Effect of Cholate

Section III Influence of Membrane Structure and Protein Synthesis on Electron Transfer Components

Topology of Drug-Metabolizing Enzymes in the Membrane of the Endoplastic Reticulum

Distribution of Electron Transfer Components on the Surface of Microsomal Membrane

Mechanism of Action of Cytochrome P-450: Role of the Microsomal Membrane

Cytochrome b5 and the Integrated Microsomal Electron Transport System

The Roles of Membrane and Substrates in the Modulation of Cytochrome P-450 Function

The Reconstitution of Microsomal Membranes

Effects of Xenobiotics on the Distributions of Monooxygenase Components in Liver

Immunohistochemical Localization of NADPH-Dependent Cytochrome c(P-450) Reductase in Liver, Lung, and Kidney of Phenobarbital- Versus Saline-Pretreated Rats: Correlations with Ultrastructural and Biochemical Observations

Microsomal Redox Proteins of Erythroid Cells: Correlating Loss of Hydrophobic Tail with Changes of Subcellular Location and Biological Activity

Properties of Purified Forms of Rabbit Liver Microsomal Cytochrome P-450 and NADPH-Cytochrome P-450 Reductase in Reconstituted Phospholipid Vesicles

Membrane Modulation of the Steroid Hydroxylase Activity of Adrenocortical Mitochondria

Methylcholanthrene and TCDD-Induced Alterations in Microsomal Electron Transport in Inbred Mice

Thermolability of Mixed-Function Oxidase Activity in Hepatic Microsomes from Little Skate, Raja Erinacea, and Rabbit

Electron Transfer Properties of NADPH-Cytochrome P-450 Reductase in Phospholipid Vesicles

Lipid Specificity of Reconstituted Purified Cytochrome P-450lm2 from Rabbit Liver

Protein-Protein and Lipid-Protein Interactions in a Reconstituted Liver Microsomal Monooxygenase System

Regulation of Mixed Function Oxidase Activity by Membrane Lipids

The Role of the Polyunsaturated Fatty Acid Composition of the Endoplasmic Reticulum in the Regulation of the Rate of Oxidative Drug and Carcinogen Metabolism

Fluidization of the Rat Liver Microsomal Membrane at Birth

Binding of Cholesterol and Adrenodoxin to Phospholipid Vesicle-Reconstituted P-450scc

Association Between Membrane Function and Phospholipid Composition in the Hepatic Endoplasmic Reticulum: Effect of Development

Association Between Membrane Function and Lipid Composition in the Hepatic Endoplasmic Reticulum: Effect of Progesterone Derivatives

Association Between Membrane Function and Lipid Composition in the Hepatic Endoplasmic Reticulum: Effect of Pregnancy

Kinetics of Hepatic Heme Turnover in Rats Given Allylisopropylacetamide: a New Model for Liver Heme Catabolism

Cytochrome P-450 Synthesis in Isolated Hepatocytes

Induction of Cytochrome P-448 and P-450 by PCB Isomers and Congeners

Impaired Induction of Hepatic Cytochrome P-450 in Selenium Deficiency

Exogenous Heme Functionally Reconstitutes Hepatic Cytochrome P-450 In Vivo

Drug-Mediated Induction of Cytochrome P-450 Hemoproteins in Primary Chick Embryo Hepatocyte Culture

Control of Cytochrome P-450 Monooxygenases in an Insect by the Steroid Moulting Hormone

In Vitro Biosynthesis of Cytochrome P-450 by Translation of Rat Liver Poly (A)+ Messenger RNA’S—Effects of Phenobarbital

Synthesis of Cytochrome P-450 Directed by Rat Liver RNA Isolated Subsequent to Phenobarbital Administration

In Vitro Synthesis of Hepatic Microsomal Cytochrome P-450

Synthesis of Cytochrome P-450 and Cytochrome P-448 in Rat Liver

Characterization of Multiple Forms of Cytochrome P-450 of Pig Liver Microsomes