Microsomes and Drug Oxidations

Microsomes and Drug Oxidations

1st Edition - January 1, 1969

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  • Editors: James R. Gillette, Allan H. Conney, George J. Cosmides
  • eBook ISBN: 9781483266336

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Description

Microsomes and Drug Oxidations documents the proceedings of symposium on microsomes and drug oxidations held at Bethesda, Maryland, 16-17 February 1968. The theme of the symposium centered on the morphology of the liver endoplasmic reticulum, the localization of enzyme systems, the mechanisms for regulating enzyme activity, and the mechanisms of enzyme action. The results of this symposium presented in this book illustrate the complexity of the enzyme systems under investigation and the multiplicity of the variables altering their function. It is hoped the information presented will serve as a stimulus to other investigators in the elucidation of these problems. The book contains 27 papers organized into four parts. The papers in Part I examine the morphological and biochemical characteristics of microsomes. Part II presents studies on electron transfer components. Part III examines alterations of microsomal enzymes while Part IV focuses on drugs and protein synthesis.

Table of Contents


  • Participants

    Preface

    I. Morphological And Biochemical Characteristics Of Microsomes

    Microsomes, Endoplasmic Reticulum, and Interactions of Cytoplasmic Membranes

    Subfractionation of Rat Liver Microsomes

    Remarks

    A Possible Role of the Endoplasmic Reticulum in the Regulation of Genetic Expression: The MEMBRON Concept

    The Metabolism of Drugs by Subfractions of Hepatic Microsomes: The Case for Microsomal Heterogeneity

    II. Electron Transfer Components

    Organization of the Microsomal Electron Transport System

    Discussion

    Characterization of Two Hemoproteins of Liver Microsomes

    Discussion

    Cytochrome P-450 Reduction in Liver Microsomes and Its Relationship to Drug Metabolism

    Discussion

    Fatty Acid co-Oxidation in a Soluble Microsomal Enzyme System Containing P-450

    Discussion

    Enzymatic w-Oxidation: Stoichiometry of the Reaction Catalyzed by the Inducible Enzyme System of Pseudomonas Oleovorans

    The Properties of a Purified Hepatic Microsomal Mixed Function Amine Oxidase

    Discussion

    A Comparison of NADPH Dependent Reductive Cleavage and N-Demethylation of Aminoazobenzene, Monomethylaminoazobenzene and Dimethylaminoazobenzene by Cell-Free Preparations from Rat Liver

    Oxygen Reactions in Model Systems

    Discussion

    Significance of the NIH Shift with Respect to Liver Microsome Hydroxylations

    Discussion

    The Microsomal Hydroxylation of Ethylbenzene: Stereochemical, Induction, and Isotopic Studies

    III. Alterations of Microsomal Enzymes

    Overall Biochemical Effects of Drug Induction on Liver Microsomes

    Discussion

    Specificity in the Regulation of the 6ß, 7α, and 16a-Hydroxylation of Testosterone by Rat Liver Microsomes

    Discussion

    Formation of a New P-450 Hemoprotein after Treatment of Rats with Polycyclic Hydrocarbons

    Discussion

    Spectrophotometric Studies of Cytochrome P-450 of Liver Microsomes after Induction with Phenobarbital and 3-Methylcholanthrene

    Discussion

    The Effects of 3-Methylcholanthrene and Phenobarbital on Liver Microsomal Hemoproteins and on the Hydroxylation of Benzpyrene

    Discussion

    Spectral Investigations on Cytochrome P-450

    Discussion

    IV. Drugs and Protein Synthesis

    Drugs and Microsomal Enzyme Formation In Vivo and in Mammalian Cell Culture

    Discussion

    Activation of Chromatin by 3-Methylcholanthrene

    Discussion

    Induction, Stabilization, and Turnover of Endoplasmic Reticulum Proteins

    Discussion

    Effect of Phenobarbital on the Turnover of Microsomal Enzymes

    Discussion

    The Role of Heme in the Synthesis and Repression of Microsomal Protein

    Discussion

    Insect Microsomes and Insecticide Chemical Oxidations

    Discussion

    Stimulatory Effect of Acetone on the Activity of Microsomal Aniline Para-Hydroxylase

    Subject Index

Product details

  • No. of pages: 562
  • Language: English
  • Copyright: © Academic Press 1969
  • Published: January 1, 1969
  • Imprint: Academic Press
  • eBook ISBN: 9781483266336

About the Editors

James R. Gillette

Allan H. Conney

George J. Cosmides

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