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Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges and Potential Benefits provides a unique and complete overview of novel formulation strategies for improvement of the delivery of NSAIDs via encapsulation in microsized and nanosized carriers composed of different materials of natural and synthetic origin.
This book presents the latest research on advances and limitations of both microsized and nanosized drug carriers and NSAIDs before discussing the formulation aspects of these drug carriers that are intended for oral, dermal, and transdermal administration of NSAIDs.
In addition, functionality of these materials as potential excipients for microsized and nanosized carriers is discussed and debated. Practical solutions for improving effectiveness of these drugs are included throughout the book, making this an important resource for graduate students, professors, and researchers in the pharmaceutical sciences.
- Covers a wide range of microsized and nanosized carriers in one resource, including particulate carriers (microparticles, nanoparticles, and zeolites) and the soft colloidal carriers, such as micro-emulsions and nano-emulsions
- Presents the reader with various formulation approaches dependent on the characteristics of the material, model drug, and desired route of administration
- Approaches are based on the latest research in the area and formulation strategies may have broader applications to the encapsulation of other active pharmaceutical ingredients
Graduate students, academic and industry researchers in the fields of pharmaceutical science and pharmaceutical technology; researchers in applied chemistry and biomolecular sciences
- List of Contributors
- Editor Biography
- Chapter 1: Clinical Uses of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and Potential Benefits of NSAIDs Modified-Release Preparations
- 1.1. Nonsteroidal anti-inflammatory drugs
- 1.2. Potential benefits of NSAIDs modified-release preparations
- 1.3. Conclusions
- Chapter 2: Polymeric Microparticles and Inorganic Micro/Nanoparticulate Drug Carriers: An Overview and Pharmaceutical Application
- 2.1. Introduction
- 2.2. Polymeric microparticles as drug carriers
- 2.3. Porous inorganic materials as drug carriers
- 2.4. Conclusions
- Chapter 3: Microemulsions and Nanoemulsions as Carriers for Delivery of NSAIDs
- 3.1. Introduction
- 3.2. Microemulsions and nanoemulsions as drug-delivery carriers
- 3.3. Design and characterization of biocompatible microemulsion/nanoemulsion drug-delivery systems
- 3.4. Evaluation of potential of microemulsion/nanoemulsion systems for oral delivery of NSAIDs
- 3.5. Conclusions
- Chapter 4: Diversity and Functionality of Excipients for Micro/Nanosized Drug Carriers
- 4.1. Introduction
- 4.2. Functionality and performance of excipients: definitions and compendial status
- 4.3. Biodegradable polymeric materials in micro/nanoparticles
- 4.4. Natural and synthetic silica-based materials as micro/nanosized drug carriers
- 4.5. Natural surfactants in micro/nanoemulsions
- 4.6. Conclusions
- Chapter 5: Influence of Polycation Functional Properties on Polyanion Micro/Nanoparticles for NSAIDs Reinforced Via Polyelectrolyte Complexation: Alginate–Chitosan Case Study
- 5.1. Introduction
- 5.2. Chitosans: an overview on properties, functionality, and safety
- 5.3. Alginate–chitosan micro/nanoparticles as drug carriers
- 5.4. Influence of chitosans functional properties on characteristics of alginate–chitosan micro/nanoparticles loaded with NSAIDs
- 5.5. Conclusions
- Chapter 6: PLA-Based Nanoparticulate Drug Carriers as a Percutaneous Delivery System for Ketoprofen
- 6.1. Introduction
- 6.2. Ketoprofen-loaded PLA nanoparticles: preparation and characterization aspects
- 6.3. In vitro evaluation of ketoprofen-loaded PLA nanoparticles as colloidal systems for percutaneous drug delivery
- 6.4. Conclusions
- Chapter 7: Natural Surfactants-Based Micro/Nanoemulsion Systems for NSAIDs—Practical Formulation Approach, Physicochemical and Biopharmaceutical Characteristics/Performances
- 7.1. Introduction
- 7.2. Sucrose ester–based microemulsions: phase behavior, physicochemical characterization, and imaging properties
- 7.3. Lecithin- and sucrose ester–based nanoemulsions—formulation design aspects, physicochemical characterization, and stability
- 7.4. NSAID-loaded micro/nanoemulsions: in vitro/ex vivo/in vivo dermal and transdermal availability
- 7.5. Conclusions
- Chapter 8: Natural and Modified Silica-Based Materials as Carriers for NSAIDs
- 8.1. Introduction
- 8.2. Natural and modified aluminosilicates: characterization and application in drug delivery
- 8.3. Modified biosilica structures from diatomite frustules: preparation, physicochemical characterization, and application
- 8.4. Conclusions
- No. of pages:
- © Academic Press 2017
- 3rd January 2017
- Academic Press
- Paperback ISBN:
- eBook ISBN:
Bojan Čalija was born in Sarajevo (Bosnia and Herzegovina). He graduated from the University in Belgrade – Faculty of Pharmacy in 2007. In 2013, he received his PhD in Pharmaceutical Technology at the University of Belgrade – Faculty of pharmacy with his PhD thesis entitled: “Functionality of chitosans in formulation of alginate-chitosan microparticles as carriers for nonsteroidal antiinflammatory drugs”. He completed postgraduate academic specialist studies in Industrial Pharmacy at the University of Belgrade - Faculty of Pharmacy in 2015.
During his master and PhD studies, he was awarded with the scholarships of the Ministry of Science and Technology of Republic of Srpska and the Ministry of Education and Culture of Republic of Srpska. In 2009, as a DAAD scholar, he was a guest researcher at the Department of Pharmaceutical Technology at the University of Technology Carolo-Wilhelmina in Braunschweig (Germany).
Since 2007, Bojan Čalija is employed at the Faculty of Pharmacy, University of Belgrade as a: teaching associate, teaching assistant and assistant professor at the Department of Pharmaceutical Technology and Cosmetology. His teaching activities are involved in the Integrated Academic Studies for Pharmaceutical Technology I, Pharmaceutical Technology II, Novel Pharmaceutical Dosage Forms, as well as Doctoral Studies in Pharmaceutical Technology and Specialist Studies in Industrial Pharmacy and Pharmaceutical Technology.
From 2008 to 2010, he was engaged in the national project of technological development: “Development and characterization of colloidal carriers for nonsteroidal anti-inflammatory drugs.” Since 2011, Bojan Čalija has participated in the national project of technological development: Development and characterization of micro and nano drug delivery systems for nonsteroidal anti-inflammatory drugs” and in the project of basic research: “Synthesis of molecules with anti-inflammatory and cardio protective activity: structural modifications, modeling, physicochemical characterization and formulational investigation”. From 2010 through 2012, he was engaged in the international Tempus project: “Postgraduate Qualification in Pharmacy - The Way Forward”.
His research is focused on formulation and characterization of polymeric microparticulate drug carriers.
Bojan Čalija is the author or the co-author of more than 60 original articles, professional papers and short communications papers. He is a peer reviewer for several international scientific journals.
He is the co-author of one textbook in the field of Pharmaceutical Technology, one workbook and one multimedia publication in the field of Industrial Pharmacy.
Department of Pharmaceutical Technology and Cosmetology, University of Belgrade - Faculty of Pharmacy, Belgrade, Serbia