MicroRNA in Human Malignancies

MicroRNA in Human Malignancies

1st Edition - February 25, 2022
  • Editors: Massimo Negrini, George Calin, Carlo Croce
  • Paperback ISBN: 9780128222874

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Description

MicroRNA in Human Malignancies offers a deep overview of the role and translational significance of miRNAs in the development of cancer and other malignancies. The book establishes the foundations of the field by covering essential mechanisms and the translational potential of miRNAs in the field of oncology. Specific topics covered include invasion and metastasis, miRNAs and metabolism, and opportunities of miRNAs in therapeutics. Chapters on diseases include content on disease-related pathophysiology, as well as diagnostic, prognostic and predictive value. This book is an essential reference for students entering the field, as well as researchers and investigators.

Key Features

  • Provides fundamental and translational chapters that facilitate the acquisition of knowledge needed to design and perform innovative miRNA-related research studies
  • Synthesizes current research, with a critical review on the field
  • Offers in-depth research by leading experts in the field

Readership

Students and researchers across the biosciences and the biomedical sciences and biotechnology fields; investigators and medical oncologists interested in both basic and translational research

Table of Contents

  • SECTION 1: miRNAs involvement in basic mechanisms of cancer development
    1. Overview on miRNA classification, biogenesis, and functions
    2. microRNA in cancer: overview
    3. miR-15/16 in human malignancies
    4. microRNAs and TP53 regulation
    5. microRNAs involvement in Invasion and metastasis
    6. microRNAs and metabolism
    7. microRNAs in inflammation processes

    SECTION 2: miRNAs methodologies
    8. Wet-lab methods for miRNA analysis
    9. Bioinformatics utilities, web resources and integrative strategies for the analysis of miRNA regulatory networks
    10. Computational Resources for Analysis of miRNA Targetome
    11. miRNA bioinformatics and pathway analysis


    SECTION 3: miRNAs involvement in therapeutics / theranostics
    12. Opportunities of miRNAs in cancer therapeutics

    SECTION 4: miRNAs involvement in human cancer: pathophysiology and translational opportunities
    13. Pathophysiology roles and translational opportunities of miRNAs in acute leukemias
    14. Pathophysiology roles and translational opportunities of miRNAs in CLL
    15. Pathophysiology roles and translational opportunities of miRNAs in Lymphoma
    16. Pathophysiology roles and translational opportunities of miRNAs in Breast cancer
    17. Pathophysiology roles and translational opportunities of miRNAs in colorectal cancer
    18. Pathophysiology roles and translational opportunities of miRNAs in Lung cancer
    19. Pathophysiology roles and translational opportunities of miRNAs in Mesothelioma
    20. Pathophysiology roles and translational opportunities of miRNAs in Renal cancer
    21. Pathophysiology roles and translational opportunities of miRNAs in Pancreatic cancer
    22. Pathophysiology roles and translational opportunities of miRNAs in Prostate cancer
    23. Pathophysiology roles and translational opportunities of miRNAs in Hepatocarcinoma
    24. Pathophysiology roles and translational opportunities of miRNAs in Ovarian cancer
    25. Pathophysiology roles and translational opportunities of miRNAs in Bladder cancer
    26. Pathophysiology roles and translational opportunities of miRNAs in Cutaneous Melanoma
    27. Pathophysiology roles and translational opportunities of miRNAs in Brain tumors
    28. Pathophysiology roles and translational opportunities of miRNAs in Sarcomas

Product details

  • No. of pages: 432
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: February 25, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780128222874

About the Editors

Massimo Negrini

Massimo Negrini is an associate professor in Oncology at the University of Ferrara, where he teaches Molecular Oncology in different graduate and post-graduate programs. He is also director of the Specialization School in Oncology at the University of Ferrara and a biologist executive at the Hospital of Ferrara. He is editor-in-chief of the journal High-Throughput, an international, open access biomedical journal focused on the use of high-throughput technologies (microarray, NGS and other) and serves on the editorial boards of several other international biomedical journals focused on nucleic acids investigation. Prof. Negrini has co-authored more than 248 papers in international peer-reviewed journals.

Affiliations and Expertise

Professor of Medical Genetics, University of Ferrara, Ferrara, Italy

George Calin

George A. Calin received both his M.D. and Ph.D. degrees at Carol Davila University of Medicine in Bucharest, Romania. Since 2007, he has run an independent research group at the M. D. Anderson Cancer Center in Houston and produced a new advance by linking new classes of non-coding RNAs to cancer. He is presently a Professor in Experimental Therapeutics at MDACC and studies the roles of microRNAs (miRNAs) and other non-coding RNAs in cancer initiation and progression and in immune disorders, as well as the mechanisms of cancer predisposition linked to ncRNAs. Furthermore, he explores the roles of body fluids miRNAs as potential hormones and biomarkers, as well as new RNA therapeutic options for cancer patients. He has co-authored more than 400 papers and over 20 book chapters

Affiliations and Expertise

Professor in Experimental Therapeutics, M. D. Anderson Cancer Center, Houston, TX, United States

Carlo Croce

Carlo M. Croce received his B.S. and M.D. degrees from University of Rome. In 1991, Dr. Croce was recruited as director of Kimmel Cancer Institute/Kimmel Cancer Center, Thomas Jefferson University. From 2004-2018, Dr. Croce served as John W. Wolfe Chair in Human Cancer Genetics, Chairman of the Department of Molecular Virology, Immunology and Medical Genetics, and Director of the Institute of Genetics, The Ohio State University (OSU). He is currently professor with the Department of Cancer Biology and Genetics at OSU. He has published more than 1,000 papers in international journals including Science, Nature, Cell, New Engl J Med, JAMA, and Cancer Cell. His research has yielded 62 issued U.S. patents. Dr. Croce is a member of the American Academy of Arts and Sciences, the American Association for the Advancement of Science, The National Academy of Sciences, the Institute of Medicine, and AACR Academy.

Affiliations and Expertise

Professor of Cancer Biology and Genetics, The Ohio State University, Columbus, OH, United States