Microfluidics for Pharmaceutical Applications - 1st Edition - ISBN: 9780128126592

Microfluidics for Pharmaceutical Applications

1st Edition

From Nano/Micro Systems Fabrication to Controlled Drug Delivery

Editors: Hélder A. Santos Dongfei Liu Hongbo Zhang
Paperback ISBN: 9780128126592
Imprint: William Andrew
Published Date: 1st September 2018
Page Count: 560
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Table of Contents

Section I: Principle of microfluidics
1. Lab-on-a-Chip technology and microfluidics
Senentxu Lanceros
2. Fluid properties and hydrodynamics of microfluidic systems
Yinghe He
3. Diffusion and mixing in microfluidic device
Jing Fan
4. Microfluidic production of multicomponent multiple emulsions
Masatoshi Maeki

Section II: Microfluidics for drug delivery applications
5. Microfabrication and Microfluidic Devices for Drug Delivery
Manabu Tokeshi, Masatoshi Maeki and Nicola Kimura
6. Lab-on-a-chip preparation routes for organic nanomaterials for drug delivery
Enza Torino and Enza Torino
7. Fabrication of different nanomaterials using microfluidic glass capillaries and nanoprecipitation
Dongfei Liu
8. Microfluidic production of inorganic nanomaterials for biomedical applications
Manuel Arruebo
9. Lab-on-a-chip synthesis of microparticles for drug encapsulation and controlled release
Liang-Yin Chu and Xiaojie Ju
10. Microfluidic technologies for local drug delivery
Shrike Zhang
11. Droplet-based microfluidics for cell encapsulation and delivery
Dong Chen and Ran Chen
12. Antibody discovery using microfluidic systems
Linas Mazutis
13. Single-cell screening using microfluidic systems
Linas Mazutis

Section III: Microfluidics for analysis and drug delivery
14. Lab-on-a-chip techniques for high throughput proteomics and drug discovery
Isao Kobayashi
15. Microfluidics for chemical analysis and sample manipulation for pharmaceutical applications
Tina Marjukka Sikanen

Section IV: Future prospective and commercialization of microfluidic techniques
18. Future of microfluidics in research and in the market
Adam Bohr


Microfluidic technology manipulates nanoliter volume of fluids in microchannels to achieve precisely controlled, efficient, and versatile nano/micro fabrications and drug encapsulations. In recent years, considerable efforts and increasing research interests have been devoted towards developing microfluidic templated drug delivery platforms. These microfluidic platforms have revolutionized the drug delivery field, which also have great potential to be scaled-up for industrial applications. This book explores advances in microfluidics for drug delivery applications from different perspectives. Topics cover the device fabrication, fluid dynamics, cutting edge microfluidic technology in global drug delivery industry, lab-on-chip nano/micro fabrication and drug encapsulation, cell encapsulation and delivery, and cell- drug interaction screening.

Microfluidics for Pharmaceutical Applications is concept-orientated and features case studies of utilizing microfluidics for drug delivery applications in an accessible manner. It is a valuable reference resource for understanding microfluidics for drug delivery applications, and also for those developing novel drug delivery platforms using microfluidics.

Key Features

  • Detailed coverage of fabrication of novel drug delivery systems with desired characteristics, such as uniform size, Janus particles, particular or combined responsiveness
  • Includes a variety of case studies explaining the principles, providing better understanding for readers
  • Focus on commercialization, cost, safety, society and educational issues of microfluidic applications, showing how microfluidics is used in the real world


No. of pages:
© William Andrew 2019
William Andrew
Paperback ISBN:

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About the Editors

Hélder A. Santos Editor

Hélder A. Santos is Associate Professor in Pharmaceutical Nanotechnology, Principal Investigator/Group Leader, Head of the Division of Pharmaceutical Chemistry and Technology, Director of the Doctoral Program in Drug Research, and Head of the Preclinical Drug Formulation and Analysis Group at the Faculty of Pharmacy, University of Helsinki (Finland). Santos' research is focused on nanobiomaterials, including nanoporous silica/silicon materials and polymeric-based nanoparticles for controlled drug delivery, diagnostics and therapy. The research interests include the development of nanoparticles/nanomedicines for biomedical and healthcare applications. His current work makes the bridge between engineering, pharmaceutical and medical research. His main research focus is in the use of biodegradable and biocompatible nanoporous silicon nanomaterials, polymers, the application of microfluidics technology for nanoparticle production for simultaneous controlled drug delivery, diagnostic and treatment of cancer, diabetes, and cardiovascular diseases, and further translation of these nanotechnologies into the clinic. He is the author/co-author of more than 220 publications, including reviews, journal editorials, book chapters and 3 patents (> 4265 citations, h-index = 40), and more than 200 conference proceedings/abstracts.

Affiliations and Expertise

Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland & Helsinki Institute of Life Science, HiLIFE, University of Helsinki, FI-00014 Helsinki, Finland

Dongfei Liu Editor

Dongfei Liu is a Postdoctoral Fellow and PI at the Division of Pharmaceutical Chemistry and Technology, University of Helsinki, Finland. He has developed a versatile and robust microfluidics platform to prepare extremely stable drug nanocrystals.

Affiliations and Expertise

Division of Pharmaceutical Chemistry and Technology, University of Helsinki, Finland

Hongbo Zhang Editor

Hongbo Zhang is an Assistant Professor at Åbo Akademi, Finland. His research focuses on nanostructured materials prepared by microfluidics for drug delivery applications.

Affiliations and Expertise

Assistant Professor, Åbo Akademi, Finland