Microbiota Brain Axis

Microbiota Brain Axis

A Neuroscience Primer

1st Edition - October 1, 2022

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  • Authors: Jane Foster, Gerard Clarke
  • Paperback ISBN: 9780128148006

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Microbiota Brain Axis: A Neuroscience Primer provides neuroscience researchers with a comprehensive guide on how to conduct effective microbiota-brain research, understand the appropriate methodologies, and collect and analyze microbiota data. The book begins with an introduction to the importance of the microbiota-brain communication in development and how microbiota impact neurodevelopmental disorders, mental health and neurodegeneration. In addition, the book discusses advances in microbiota analysis tools and techniques for neuroscience related research.

Key Features

  • Reviews the many approaches to manipulating the microbiota in animal studies - including the use of germ-free animals, antibiotics and diet - and covers the strengths and limitations of each
  • Outlines available microbiota research tools, such as 16S sequencing and shot-gun metagenomics
  • Provides a comprehensive guide to analyzing microbiota-related data and the many choices for bioinformatics


Advanced students, basic researchers, and clinical researchers in behavioral neuroscience, neuroimmunology, biological psychiatry, developmental neuroscience, and related fields; researchers in physiology, nutrition, immunology, and gastroenterology

Table of Contents

  • 1. Gut-brain Axis
    2. Research approaches to manipulate/study microbiota
    3. Microbiota analysis tools and techniques
    4. What is a healthy microbiome?
    5. Gene-environment contributions to microbiota composition, diversity, and function
    6. Microbiota-brain communication in neurodevelopment – the first 1000 days
    7. Microbiota in neurodevelopmental disorders
    8. Microbiota-brain interactions in mental health – adolescence and adult
    9. Microbiota-brain interactions in neurodegeneration
    10. Antibiotics
    11. Probiotics
    12. Fecal transplantation
    13. Microbiota-related biomarkers for precision medicine and drug discovery
    14. Future considerations

Product details

  • No. of pages: 496
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: October 1, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780128148006

About the Authors

Jane Foster

Dr. Jane Foster is a Professor in the Department of Psychiatry and Behavioural Neurosciences at McMaster University in Hamilton, ON, a Scientific Associate at University Health Network and a Scientist at St. Michael’s Hospital in Toronto, ON. Dr. Foster is an active researcher in the Province of Ontario Neurodevelopmental Disorders Network (POND) and the Canadian Biomarker Integration Network in Depression in Depression (CAN-BIND). The Foster lab research team focuses on the role of microbiota-immune-brain interacations on neurodevelopment, behaviour, and brain function and aims to understand how these relationships contribute to psychiatric disorders such as neurodevelopmental disorders, anxiety and depression.

Affiliations and Expertise

Professor, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada

Gerard Clarke

Gerard Clarke
Dr Gerard Clarke is a Lecturer in the Department of Psychiatry and Neurobehavioural Science and a Principal Investigator in APC Microbiome Ireland at University College Cork. His research interests include translational biomarkers of stress-related neuropsychiatric disorders, the impact of the gut microbiome on brain and behaviour across the life span and microbial regulation of tryptophan metabolism. Target human populations of his research include those with major depression and anxiety as well as gastrointestinal disorders with high psychiatric comorbidities such as irritable bowel syndrome.

Affiliations and Expertise

Lecturer, Department of Psychiatry and Neurobehavioural Science and Principal Investigator, APC Microbiome Ireland, University College Cork, Cork, Ireland

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