Microbiome Metabolome Brain Vagus Nerve Circuit in Disease and Recovery

Microbiome Metabolome Brain Vagus Nerve Circuit in Disease and Recovery

1st Edition - December 1, 2022

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  • Author: Elena Paley
  • Paperback ISBN: 9780443191220

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Description

Microbiome Metabolome Brain Vagus Nerve Circuit in Disease and Recovery focuses on the emerging hypothesis of a dysfunctional microbiome – metabolome - vagus nerve - brain circuit in Alzheimer’s disease and associated diseases and medical conditions, including dementia, aging, COVID-19, and autoimmune conditions including rosacea. This volume also discusses the vagus nerve-related conditions including Arnold’s reflex, laryngopharyngeal reflux, duodenogastric reflux, gastroesophageal reflux, and related pulmonary diseases. The subjects covered in this book also address an important question: which one is more important for human health and intellectual abilities: the human genome or human microbiome? The conceptual model of food and gut microbial tryptamine - vagus nerve circuit is also presented in this volume.

Key Features

  • Addresses the emerging hypothesis of a dysfunctional microbiome - vagus nerve - brain circuit in Alzheimer’s disease and associated diseases and medical conditions
  • Covers dementia, aging, COVID-19, and autoimmune conditions including rosacea
  • Presents the conceptual model of food and gut microbial tryptamine - vagus nerve circuit
  • Covers human health and intellectual abilities in the context of both the human genome and the human microbiome

Readership

Neuroscientists, diagnosticians, clinicians, scientists working with preclinical models or drug development

Table of Contents

  • 1. Introduction: microbial metabolite interference of protein biosynthesis in neurodegenerative, neurodevelopmental and other disorders; microbial metabolites hijacking vagus nerve

    2. COVID-19: Scientific Progress

    3. Viral-bacterial interactions in diseases

    4. Vagus nerve: acid reflux, parietal cells, carpal tunnel syndrome, Alzheimer’s disease, COVID-19, stroke, cancer and other diseases

    5. Vagus nerve circuit: microbiome - tryptophan metabolites – receptors and synapses

    6. Glutamate, glutamate receptors in vagus nerve pathways and in Alzheimer’s disease

    7. Aminoacyl tRNA synthetase multiple forms in autoimmune and infectious diseases

    8. Crystalized aromatic L-amino acid decarboxylase from bacteria Micrococcus percitreus catalyzing decarboxylation of tryptophan and L-DOPA (Levodopa or 3,4-dihydroxy-L-phenylalanine)

    9. Health effects of elevated CO2 levels, sparkling mineral water, Seltzer carbonated water

    10. Microbial antigens, allergies and antibodies to microbial allergens: significance of pre-existing antibodies for vaccination

    11. Vagus nerve and taste identification deficits in disease

    12. Microorganisms producing biogenic amines: from food to human body

    13. Human genome or human microbiome genes: which one is more important for human health and intellectual abilities?

    14. Microorganisms used in agriculture, consumed from environment and associated with the edible raw fruits, vegetables, herbs, sprouts, and mushrooms

    15. Molecular and cell aggregation: biogenic amines, proteins, platelets and microbial pathogens

    16. Colonic diverticular disease as a risk factor for neurodegenerative and associated diseases

    17. Alzheimer’s disease, Dementia, Aging and COVID-19

    18. Existing vaccines and new and old tools

    19. Serotonin syndrome in neurodegenerative diseases and COVID-19: mechanisms and consequences of intestinal infection

    20. Circulating cell-free mitochondria and membrane vesicles

    21. Protein synthesis inhibition in neuronal activities

    22. Rosacea and associated medical disorders

    23. Bacterial internalization in cancer and other medical conditions: intracellular pathogens

    24. Ocular changes resulting from reading and writing on smartphone and computer: computer vision syndrome, dry eye disease, meibomian gland dysfunction, chalazion, occupational overuse syndrome

    25. Viral infections in vagus nerve

    26. Microbial Tryptamine in Type 1, Type 2 and Type 3 diabetes

Product details

  • No. of pages: 450
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: December 1, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780443191220

About the Author

Elena Paley

Dr. Elena Paley is the Founder, President & CEO of Expert Biomed Inc., and Co-founder and Director of Stop Alzheimer’s Corp. She completed her PhD in Biology at The Engelhardt Institute of Molecular Biology, at the Russian Academy of Sciences, Moscow, Russia and later conducted postdoctoral research at the University of Miami School of Medicine, Miami, FL. Dr. Paley's research focuses on protein biosynthesis interference in disease, with emphasis on cancer and neurodegenerative disease. During her career she has taught and held professorships at Northwestern University Feinberg School of Medicine and Nova Southeastern University in Ft. Lauderdale, FL, among other schools. Dr. Paley is on the review board of various scientific journals, including the Journal of Alzheimer’s Disease and Current Alzheimer Research.

Affiliations and Expertise

Founder, President and CEO Expert Biomed Inc.; Co-founder and Director Stop Alzheimer’s Corp.; Adjunct Professor, Nova Southeastern University, FL, USA; The Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia

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