Microbial Transformations of Steroids

Microbial Transformations of Steroids

A Handbook

1st Edition - January 1, 1967

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  • Authors: William Charney, Hershel L. Herzog
  • eBook ISBN: 9781483261553

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Description

Microbial Transformations of Steroids: A Handbook aims to provide those who wish to use microbial transformations of steroids with a single source book starting from 1937 to the present. The handbook first offers information on the history of the microbial transformations of organic compounds, including earliest works on the study of nonsteroids and steroids; significance of discovery of anti-inflammatory action of cortisone; first hydroxylations and dehydrogenations; manufacture of natural and synthetic corticosteroids; and trends in research. The text then ponders on chemical classification of microbial transformations of steroids, as well as the role of enzymes in microbial transformations and the classes of reactions. The publication elaborates on the construction and use of the table. Topics include order of the table, nomenclature, description of the transformation leading to the product, yield, organism, and constants. The book also focuses on taxonomy and use of the table, including system of classification, specific notes on divisions of the table, and source of cultures. The handbook is a valuable source of data for readers interested in the microbial transformations of steroids.

Table of Contents


  • Preface

    Chapter I Introduction

    Earliest Work - Nonsteroid

    Earliest Work - Steroid

    Significance of Discovery of Antiinflammatory Action of Cortisone

    First Hydroxylations

    First Dehydrogenations

    Manufacture of Natural and Synthetic Corticosteroids

    New Trends in Research

    Chapter II Chemical Classification of Microbial Transformations of Steroids

    The Role of Enzymes in Microbial Transformations

    Practical Implications

    The Classes of Chemical Reactions

    Oxidation

    Reduction

    Esterification of Steroid Alcohols

    Isomerization of Double Bonds

    Miscellaneous Addition, Rearrangement, and Elimination Processes

    Resolution of Steroids from Total Synthesis

    Chapter III The Construction and Use of Table I

    Order of the Table

    Nomenclature

    Description of the Transformation Leading to the Product

    Yield

    Organism

    Constants

    References

    Table I: Transformations by Product

    Chapter IV Taxonomy

    System of Classification

    Classes and Major Orders of Fungi and Bacteria (Reported to Transform Steroids)

    Hydroxylation - Taxonomic Distribution According to Order

    Hydroxylation - Taxonomic Distribution According to Genus

    Δ1-Dehydrogenation - Taxonomic Distribution According to Genus

    Table II: Taxonomy to Species

    Chapter V The Construction and Use of Table III - Transformations by Genus

    Order of the Table

    Specific Notes on Divisions of the Table

    Genera

    Species

    Sources

    Substrates

    Reactions

    References

    Culture Collections (Source of Cultures)

    Table III: Transformations by Genus

    Chapter VI Bibliography

    Chapter VII Bibliographical Appendix


Product details

  • No. of pages: 742
  • Language: English
  • Copyright: © Academic Press 1967
  • Published: January 1, 1967
  • Imprint: Academic Press
  • eBook ISBN: 9781483261553

About the Authors

William Charney

Hershel L. Herzog

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