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Microbial Glycobiology
1st Edition
Structures, Relevance and Applications
Editors:
Author:
- eBook ISBN 9780080923246
- Print ISBN 9780123745460
Description
This book presents in an easy-to-read format a summary of the important central aspects of microbial glycobiology, i.e. the study of carbohydrates as related to the biology of microorganisms. Microbial glycobiology represents a multidisciplinary and emerging area with implications for a range of basic and applied research fields, as well as having industrial, medical and biotechnological implications.
Key Features
Key Features and Benefits
* Individual chapters provided by leading international scientists in the field yield insightful, concise and stimulating reviews.
- Provides researchers with an overview and synthesis of the latest research
* Each chapter begins with a brief 200 word Summary/Abstract detailing the topic and focus of the chapter, as well as the concepts to be addressed.
- Allows researchers to see at a glance what each chapter will cover
* Each chapter includes a Research Focus Box
- Identifies important problems that still need to be solved and areas that require further investigation
* Individual chapters provided by leading international scientists in the field yield insightful, concise and stimulating reviews.
- Provides researchers with an overview and synthesis of the latest research
* Each chapter begins with a brief 200 word Summary/Abstract detailing the topic and focus of the chapter, as well as the concepts to be addressed.
- Allows researchers to see at a glance what each chapter will cover
* Each chapter includes a Research Focus Box
- Identifies important problems that still need to be solved and areas that require further investigation
Readership
Researchers and graduate students in both academia and industry:
Microbiologists
Infectious disease specialists
These researchers are trying to understand how certain microbial pathogens (protozoa, bacteria, fungi, viruses etc) cause disease in humans. With insights from microbial glycobiology new diagnostic methods can be designed to detect the infectious agent and also to determine if one bug is more virulent than another, thus, helping disease diagnosis.
Microbial glycobiology allows them to examine the role that sugars play in the disease process and help them determine a way to prevent a pathogen causing disease. Hence, new insights will be gained that could aid boost the immune system, thereby new biotheraputics and vaccines are being developed
Biochemists
Carbohydrate chemists (analytical and synthetic)
By determining the structure of glycosylated proteins, lipids and other natural products from microbes, researchers can reveal the location of the sugars. They then have the ability to modify and control which sugars are attached and exactly how they are attached. This is important as it enables them to modify glycosylated biomolecules that are important in disease processes and turn these into better drugs.
Researchers in biomedical, diagnostic and biopharmaceutical companies
Pharmacologists are using microbial glycobiology to produce carbohydrate-based diagnostics, vaccines, drugs and immunotherapeutics.
From the insights gained of the enzymes used in the natural synthesis of the glycosylated molecules in microbes, manipulations using these enzymes can be made to synthesise newer glycosylated structures that can be used in therapeutics or for obtaining correct glycosylation of cloned human proteins used in biotherapeutics.
Since glycosylation determines the half-life of many biotherapeutics, usage of knowledge from glycosylation systems from microbes can help manufacture more effective therapeu
Microbiologists
Infectious disease specialists
These researchers are trying to understand how certain microbial pathogens (protozoa, bacteria, fungi, viruses etc) cause disease in humans. With insights from microbial glycobiology new diagnostic methods can be designed to detect the infectious agent and also to determine if one bug is more virulent than another, thus, helping disease diagnosis.
Microbial glycobiology allows them to examine the role that sugars play in the disease process and help them determine a way to prevent a pathogen causing disease. Hence, new insights will be gained that could aid boost the immune system, thereby new biotheraputics and vaccines are being developed
Biochemists
Carbohydrate chemists (analytical and synthetic)
By determining the structure of glycosylated proteins, lipids and other natural products from microbes, researchers can reveal the location of the sugars. They then have the ability to modify and control which sugars are attached and exactly how they are attached. This is important as it enables them to modify glycosylated biomolecules that are important in disease processes and turn these into better drugs.
Researchers in biomedical, diagnostic and biopharmaceutical companies
Pharmacologists are using microbial glycobiology to produce carbohydrate-based diagnostics, vaccines, drugs and immunotherapeutics.
From the insights gained of the enzymes used in the natural synthesis of the glycosylated molecules in microbes, manipulations using these enzymes can be made to synthesise newer glycosylated structures that can be used in therapeutics or for obtaining correct glycosylation of cloned human proteins used in biotherapeutics.
Since glycosylation determines the half-life of many biotherapeutics, usage of knowledge from glycosylation systems from microbes can help manufacture more effective therapeu
Table of Contents
Part I. Microbial glycolipids, glyoproteins and glycopolymers 1. Overview of the glycosylated components of the bacterial cell wall 2. Bacterial cell wall envelope peptidoglycan 3. Core oligosaccharide and lipid A components of lipopolysaccharides 4. O-Specific polysaccharides of Gram-negative bacteria 5. Teichoic acids, lipoteichoic acids, and related cell wall glycopolymers of Gram-positive bacteria 6. Bacterial capsular polysaccharides and exopolysaccharides 7. Bacterial surface layer glycoproteins and “non-classical” secondary cell wall polymers 8. Glycosylation of bacterial and archaeal flagellins 9. Glycosylated components of the mycobacterial cell wall: structure and function 10. Glycoconjugate structure and function in fungal cell walls 11. Cytoplasmic carbohydrate molecules: trehalose and glycogen 12. Glycosylated compounds of parasitic protozoa 13. Analytical approaches towards the structural characterization of microbial wall glycopolymers 14. Single-molecule characterization of microbial polysaccharides 15. Viral surface glycoproteins in carbohydrate recognition: structure and modeling Part II. Synthesis of microbial glycosylated components; A. Biosynthesis and biosynthetic processes 16. Biosynthesis of bacterial peptidoglycan 17. Biosynthesis and membrane assembly of lipid A 18. Biosynthesis of O-antigen chains and assembly 19. Biosynthesis of cell wall teichoic acid polymers 20. Biosynthesis and assembly of capsular polysaccharides 21. Biosynthesis of the mycobacterial cell envelope components 22. Biosynthesis of fungal and yeast glycans B. Chemical synthesis 23. Chemical synthesis of bacterial lipid A 24. Chemical synthesis of the core oligosaccharide of bacterial lip
Details
- No. of pages:
- 1036
- Language:
- English
- Copyright:
- © 2009
- Published:
- 31st August 2009
- Imprint:
- Academic Press
- eBook ISBN:
- 9780080923246
- Print ISBN:
- 9780123745460
About the editors
Anthony Moran
Affiliations and Expertise
National University of Ireland, Galway and Institute for Glycomics, Griffith University, Australia
Otto Holst
Affiliations and Expertise
Leibniz-Center for Medicine and Biosciences, Borstel, Germany
Patrick Brennan
Affiliations and Expertise
Colorado State University, Fort Collins, USA
Mark von Itzstein
Affiliations and Expertise
Institute for Glycomics, Griffith University, Australia
About the author
Anthony Moran
Affiliations and Expertise
National University of Ireland, Galway and Institute for Glycomics, Griffith University, Australia