Description

This book presents in an easy-to-read format a summary of the important central aspects of microbial glycobiology, i.e. the study of carbohydrates as related to the biology of microorganisms. Microbial glycobiology represents a multidisciplinary and emerging area with implications for a range of basic and applied research fields, as well as having industrial, medical and biotechnological implications.

Key Features

Key Features and Benefits

* Individual chapters provided by leading international scientists in the field yield insightful, concise and stimulating reviews.
- Provides researchers with an overview and synthesis of the latest research

* Each chapter begins with a brief 200 word Summary/Abstract detailing the topic and focus of the chapter, as well as the concepts to be addressed.
- Allows researchers to see at a glance what each chapter will cover

* Each chapter includes a Research Focus Box
- Identifies important problems that still need to be solved and areas that require further investigation


Readership

Researchers and graduate students in both academia and industry:

Microbiologists
Infectious disease specialists

These researchers are trying to understand how certain microbial pathogens (protozoa, bacteria, fungi, viruses etc) cause disease in humans. With insights from microbial glycobiology new diagnostic methods can be designed to detect the infectious agent and also to determine if one bug is more virulent than another, thus, helping disease diagnosis.

Microbial glycobiology allows them to examine the role that sugars play in the disease process and help them determine a way to prevent a pathogen causing disease. Hence, new insights will be gained that could aid boost the immune system, thereby new biotheraputics and vaccines are being developed

Biochemists
Carbohydrate chemists (analytical and synthetic)

By determining the structure of glycosylated proteins, lipids and other natural products from microbes, researchers can reveal the location of the sugars. They then have the ability to modify and control which sugars are attached and exactly how they are attached. This is important as it enables them to modify glycosylated biomolecules that are important in disease processes and turn these into better drugs.

Researchers in biomedical, diagnostic and biopharmaceutical companies
Pharmacologists are using microbial glycobiology to produce carbohydrate-based diagnostics, vaccines, drugs and immunotherapeutics.

From the insights gained of the enzymes used in the natural synthesis of the glycosylated molecules in microbes, manipulations using these enzymes can be made to synthesise newer glycosylated structures that can be used in therapeutics or for obtaining correct glycosylation of cloned human proteins used in biotherapeutics.

Since glycosylation determines the half-life of many biotherapeutics, usage of knowledge from glycosylation systems from microbes can help manufacture more effective therapeu

Table of Contents

Part I. Microbial glycolipids, glyoproteins and glycopolymers  1. Overview of the glycosylated components of the bacterial cell wall   2. Bacterial cell wall envelope peptidoglycan   3. Core oligosaccharide and lipid A components of lipopolysaccharides   4. O-Specific polysaccharides of Gram-negative bacteria   5. Teichoic acids, lipoteichoic acids, and related cell wall glycopolymers of Gram-positive bacteria   6. Bacterial capsular polysaccharides and exopolysaccharides   7. Bacterial surface layer glycoproteins and “non-classical” secondary cell wall polymers   8. Glycosylation of bacterial and archaeal flagellins   9. Glycosylated components of the mycobacterial cell wall: structure and function   10. Glycoconjugate structure and function in fungal cell walls   11. Cytoplasmic carbohydrate molecules: trehalose and glycogen   12. Glycosylated compounds of parasitic protozoa   13. Analytical approaches towards the structural characterization of microbial wall glycopolymers   14. Single-molecule characterization of microbial polysaccharides   15. Viral surface glycoproteins in carbohydrate recognition: structure and modeling Part II. Synthesis of microbial glycosylated components; A. Biosynthesis and biosynthetic processes  16. Biosynthesis of bacterial peptidoglycan   17. Biosynthesis and membrane assembly of lipid A   18. Biosynthesis of O-antigen chains and assembly   19. Biosynthesis of cell wall teichoic acid polymers   20. Biosynthesis and assembly of capsular polysaccharides   21. Biosynthesis of the mycobacterial cell envelope components   22. Biosynthesis of fungal and yeast glycans B. Chemical synthesis   23. Chemical synthesis of bacterial lipid A   24. Chemical synthesis of the core oligosaccharide of bacterial lip

Details

No. of pages:
1036
Language:
English
Copyright:
© 2009
Published:
Imprint:
Academic Press
eBook ISBN:
9780080923246
Print ISBN:
9780123745460

About the editors

Anthony Moran

Affiliations and Expertise

National University of Ireland, Galway and Institute for Glycomics, Griffith University, Australia

Otto Holst

Affiliations and Expertise

Leibniz-Center for Medicine and Biosciences, Borstel, Germany

Patrick Brennan

Affiliations and Expertise

Colorado State University, Fort Collins, USA

Mark von Itzstein

Affiliations and Expertise

Institute for Glycomics, Griffith University, Australia

About the author

Anthony Moran

Affiliations and Expertise

National University of Ireland, Galway and Institute for Glycomics, Griffith University, Australia