Microbial Biofilms

Role in Human Infectious Diseases

1st Edition - April 10, 2024
Editors: Mukesh Kumar Yadav, Jae Jun Song, Jorge E. Vidal
Language: English
Paperback ISBN:
9 7 8 - 0 - 4 4 3 - 1 9 2 5 2 - 4
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 9 2 5 3 - 1

Microbial biofilms are serious problem in medical settings as they are associated with significant mortality and morbidity. Infection related to biofilms not only increases re… Read more

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Microbial biofilms are serious problem in medical settings as they are associated with significant mortality and morbidity. Infection related to biofilms not only increases recovery time, but also escalates the cost of disease management. Biofilms are intrinsically resistant to antibiotics and evade human defense mechanisms. In addition, the close proximity of microbes within biofilms promotes genetic transformation, facilitating the acquisition of antibiotic-resistant genes and leading to an increased prevalence of diseases associated with resistance. Fortunately, with advances in science and technology, novel strategies are being utilized to mitigate the impact of biofilms on human health.

Microbial Biofilms: Role in Human Infectious Diseases focuses on new and emerging concepts in microbial biofilm research. It explores topics such as the mechanisms of biofilm formation, biofilm-induced pathogenesis, biofilm detection and diagnosis, gene exchange within biofilms, strategies to control microbial biofilms, and the burden of biofilm-associated infections. Additionally, the book highlights the various antibiofilm strategies, such as surface coating, signal quenching, novel compounds that can be translated to curb biofilm-associated infections, and the escalation of antimicrobial resistance determinants.

Cover image
Title page
Table of Contents
Copyright
List of contributors
1. Application of nanoparticles to combat dental biofilms
Abstract
1.1 Dental biofilms
1.2 Nanoparticles
1.3 Application of nanoparticles to treat dental biofilms
1.4 Treatment of periodontal disease
1.5 Future perspective on the applications of nanoparticles
1.6 Conclusion
References
2. Streptococcus biofilms: role in human infectious diseases
Abstract
2.1 Introduction
2.2 Classification of Streptococcus species
2.3 Biofilm mode of growth of Streptococcus species
2.4 Streptococcus biofilm-related infectious diseases
2.5 Conclusion and future perspective
Acknowledgment
References
3. Single-species and multispecies biofilms causing infections
Abstract
3.1 Introduction
3.2 Role of biofilm in disease
3.3 Concluding remarks
References
4. Gut microbiota: role of biofilms in human health
Abstract
4.1 Introduction
4.2 Types of bacteria and their spatial distribution
4.3 The trajectory of gut microbiota in infants
4.4 Factors affecting gut microbiota
4.5 Microbial dysbiosis
4.6 Gut metabolite
4.7 Microbial biofilm
4.8 Conclusion
References
5. Natural compounds to combat microbial biofilms
Abstract
5.1 Introduction
5.2 Terpenes
5.3 Flavonoids
5.4 Alkaloids
5.5 Conclusions
References
6. Vaginal microbiota biofilm in pregnancy and birth outcome: function and prospects
Abstract
6.1 Introduction
6.2 Vaginal microbiota profile and dysbiosis during pregnancy
6.3 Vaginal microbiota dysbiosis and biofilm formation during pregnancy
6.4 Vaginal microbiota biofilm formation during pregnancy and birth outcome
6.5 Therapeutic insight of beneficial against pathogenic vaginal microbiota biofilm
6.6 Conclusion and future prospective
Author contributions
Acknowledgments
Conflict of interest
References
7. Microbial biofilms and their role in acute and chronic pathogenesis
Abstract
7.1 Introduction to biofilm: a microbial life on surface
7.2 Historical perspective of biofilm
7.3 Biofilm and its structural component
7.4 Biofilm mode of growth of bacteria
7.5 Role of biofilms in human health
7.6 Microbiome and biofilm formation in lungs
7.7 Role of biofilms in respiratory tract and acute and chronic pathogenesis
7.8 Control of biofilms in respiratory infection
7.9 Conclusion
References
8. Surface modification: strategies to prevent microbial growth on medical implants
Abstract
8.1 Introduction
8.2 Understanding microbial growth on medical implants
8.3 Inhibition of microbial adhesion to device surfaces
8.4 Promoting microbial killing within an established biofilm
8.5 Physical surface modification
8.6 Nanopatterning
8.7 Surface chemical modifications
8.8 Conclusion and future prospective
Acknowledgment
References
9. Microbial biofilms and the skin microbiome
Abstract
9.1 Introduction
9.2 Microbial biofilm and skin disease
9.3 Skin burn infection
9.4 Pressure ulcers
9.5 Conclusion
References
10. Cell-to-cell interaction and cell signaling in biofilm formation
Abstract
10.1 Introduction
10.2 Relevance and risk of biofilm
10.3 Factors associated with biofilm formations
10.4 Mechanism of biofilm formation and cell-to-cell interaction
10.5 Relevance and risk of biofilm
10.6 Factors associated with biofilm formation
10.7 Cell-to-cell signaling and signal interception
10.8 Conclusions and future prospective
References
11. A concise review on genes involved in biofilm-related disease and differential gene expression in medical-related biofilms
Abstract
11.1 Introduction
11.2 Genes involved in biofilm formation
11.3 Differential gene expression in pathogenic biofilms
11.4 Genes involved in pathogenic biofilms
11.5 Future perspectives
References
12. Next-generation sequencing: role in microbial biofilm study
Abstract
12.1 Introduction
12.2 Next-generation sequencing
12.3 Next-generation sequencing to study biofilms
12.4 Conclusion and future perspective
References
13. Electrical signaling in growth dynamics of microbial biofilms
Abstract
13.1 Introduction
13.2 Effectiveness of communication ensured survival
13.3 Communication is crucial for the evolution of complex life
13.4 Efficient communication forms the basis of biofilm evolution
13.5 Chemical signaling in microbes: quorum sensing
13.6 Electrical signaling in microbial biofilms
13.7 Summary
References
Index

Mukesh Kumar Yadav

Dr. Mukesh Kumar Yadav, is working as an Associate Professor at the Department of Microbiology, Central University of Punjab, Bathinda, Punjab, India. He has more than 15 years of research experience in the field of microbiology in general and microbial biofilms, host-pathogen interaction and endophytes in particular. In his laboratory, Dr. Yadav’s is working on microbial biofilms, antimicrobial resistance, pathogenesis and identification of novel pathways for the development of new antimicrobial/antibiofilm compounds. Dr. Yadav has published more than 74 research articles and received research grants from various funding agencies like, NRF Korea, Indian Council of Medical Research (ICMR), Department of Science and Technology (DST), Department of Biotechnology (DBT) and University Grant Commission (UGC).

Affiliations and expertise

Associate Professor, Department of Microbiology, Central University of Punjab, Bathinda, Punjab, India

Jae Jun Song

Prof. Jae Jun Song is a Professor at Korea University College of medicine Seoul, South Korea. Prof. Song is clinical professional and has more than 15 years of research experience. He has published more than 80 research papers in peer-reviewed journals and has completed many research grants related to microbial biofilms

Affiliations and expertise

Professor, Department of Otorhinolaryngology – Head and Neck Surgery, Korea University College of Medicine, South Korea

Jorge E. Vidal

Dr. Jorge E. Vidal is an Associate Professor in the Department of Cell and Molecular Biology and a member of the Center for Immunology and Microbial Research at the University of Mississippi Medical Center. In his research laboratory, Dr. Vidal studies the molecular mechanisms of bacterial pathogenesis, biofilm formation, and the mechanisms leading to the acquisition of antibiotic resistance. Dr. Vidal has published more than 100 research papers and has received several research grants from the NIH, BMGF, Pfizer, and other agencies.

Affiliations and expertise

Department of Microbiology and Immunology, University of Mississippi Medical Center, Jackson, USA