Microbial biofilms: Role in Human Infectious Diseases focuses on new and emerging concepts in microbial biofilm research, such as the mechanisms of biofilm formation, biofilm-induced pathogenesis, biofilm detection/and diagnosis, gene exchange within biofilms, strategies to control microbial biofilms and the burden of biofilm associated infections. In addition, it highlights the various anti-biofilm strategies such as surface coating, signal quenching, novel compounds that can be translated to curb biofilm-associated infections and the escalation of antimicrobial resistance determinants. Microbial biofilms can be a serious problem in medical settings as they are associated with significant mortality and morbidity. Infection related to biofilms increases recovery time and the cost of disease management. Biofilms are resistant to known antibiotics and human defense mechanism. In addition, due to close proximity of microbes within biofilms, increase genetic transformation has been detected results in increases frequency of antibiotic gene spread. With the advancement in science and technology, novel strategies have been proposed to combat the impact of biofilms on human health.
Fulfils the knowledge gap in biofilm study
Focuses on new and emerging concepts in microbial biofilm research
Highlights the various anti-biofilm strategies
Provides concise, thorough and up-to-date information about the important role of microbial biofilms in human diseases
Graduate students, Post-graduate students, along with researchers and PhD scholars working in the field of biotechnology, clinicians, scientists and industry personnel working on microbial biotechnology and medical microbiology, microbiology and immunology
Table of Contents
1. Bacterial Biofilms and infectious disease in human health: a concise review 2. Microbial biofilms: Role of biofilms in recurrent orthopaedic infections 3. Dental biofilms: Application of nanoparticles to combat biofilms 4. Streptococcus biofilms, and their role in human infectious diseases 5. Surface coating: Strategy to prevent bacteria adhesion on medical implants 6. Bacterial biofilm a major challenge in medical indwelling devices 7. Single-species and multi-species biofilms causing infections 8. Effects of environmental factors to promote formation of biofilms by respiratory pathogens 9. Gut Microbiota: Role of biofilms in human health 10. Antimicrobial/antibiotic resistance of biofilms and factors contributing to resistance 11. Cell to cell interaction and cell signalling in biofilms 12. Microbial biofilms and the skin microbiome 13. Synthetic and phyto-compounds to combat microbial biofilms 14. Next generation sequencing: Role in microbial biofilms study
Dr. Mukesh Kumar Yadav, is working as an Assistant Professor at the Department of Biotechnology, at Mizoram University, India. He has more than 12 years of research experience in the field of microbiology in general and microbial biofilms, host-pathogen interaction and entophytes in particular. Dr. Yadav’s research is focused on microbial biofilms in clinical settings. He is particularly interested in microbial biofilms related to pathogenesis and in the identification of novel pathways for the development of new antimicrobial/antibiofilm compounds. The host-response during single species or multi-species colonization in vivo is also an important part of his study. Using in vitro biofilm models and in vivo colonization models, his group have identified a number of natural and synthetic compounds that are effective in controlling bacterial growth in planktonic bacteria as well as under biofilm state. Dr. Yadav has completed four major research projects on microbial biofilms, and has published more than 45 research articles.
Affiliations and Expertise
Assistant Professor, Department of Biotechnology, Mizoram University (A Central University), Pachhunga University College Campus, Mizoram, India
Prof. Jae Jun Song is a Professor at Korea University College of medicine Seoul, South Korea. Prof. Song is clinical professional and has more than 15 years of research experience. He has published more than 80 research papers in peer-reviewed journals, with more than 3920 citations and h-index 32. He has completed many research grants related to microbial biofilms. Prof. Song laboratory is involved in the study the structure of biofilms, effects of antibiotics and discovery of new compounds to control bacterial biofilm, host pathogen interaction, multi-species biofilms, biofilm role in otitis media. Using both in vitro and in vivo rat and mouse model Prof. Song research team is try to gain more depth knowledge of biofilms made by species of genera Streptococcus, Staphylococcus, and Pseudomonas.
Affiliations and Expertise
Professor, Department of Otorhinolaryngology – Head and Neck Surgery, Korea University College of Medicine, South Korea
Dr. Vidal was recruited by Larry McDaniel to the UMMC Department of Microbiology and Immunology where he currently has his research laboratory. His research programs and academic activities have been generously funded through grants from the NIH, BMGF, Pfizer, Cempra pharmaceuticals, Melinta Pharmaceuticals, Nabriva Pharmaceuticals, NIH-sponsored ACTSI, and others. Dr. Vidal has published more than 80 research papers in top journals of microbiology with 3018 citation and 33 h-index and 64 i10-index.
Dr Vidal is a member of the American Society for Microbiology (ASM), 2001-present. Witihn the ASM, Dr. Vidal is a member of the sub-Committee on Microbiological Issues Impacting Minorities (CMIIM) 2017-Present and member of the sub-Committee on Minority Education (CME), 2018-Present.
Dr. Vidal’s research area includes Molecular pathogenesis of Streptococcus pneumoniae (pneumococcus), molecular epidemiology of pneumococcal disease, Acquisition of antibiotic resistance and molecular studies of biofilms produced by respiratory pathogens.
Affiliations and Expertise
Department of Microbiology and Immunology, University of Mississippi Medical Center, Jackson, USA