This work encapsulates the uses of miRNA across stem cells, developmental biology, tissue injury and tissue regeneration. In particular contributors provide focused coverage of methodologies, intervention and tissue engineering.Regulating virtually all biological processes, the genome’s 1048 encoded microRNAs appear to hold considerable promise for the potential repair and regeneration of tissues and organs in future therapies. In this work, 50 experts address key topics of this fast-emerging field. Concisely summarizing and evaluating key findings emerging from fundamental research into translational application, they point to the current and future significance of clinical research in the miRNA area. Coverage encompasses all major aspects of fundamental stem cell and developmental biology, including the uses of miRNA across repair and regeneration, and special coverage of methodologies and interventions as they point towards organ and tissue engineering
- Multi-colour text layout with 150 colour figures to illustrate important findings
- Take home messages encapsulate key lessons throughout text
- Short chapters offer focused discussion and clear ‘voice’
Graduate students studying stem cell biology and regenerative and reparative medicine
- Dedication <li>Part 1. Stem Cells<ul><li>Chapter 1. MicroRNA Biogenesis in Regenerative Medicine<ul><li>1.1. Introduction</li><li>1.2. Macro Impact of miRNAs</li><li>1.3. miRNA Biogenesis: Different Paths to the Same Destination</li><li>1.4. Mechanisms of miRNA-Induced Translational Repression</li><li>1.5. miRNA Regulation</li><li>1.6. Methods for miRNA Profiling</li><li>1.7. Bioinformatics Analysis of miRNAs</li><li>1.8. miRNA Applications in Regenerative Medicine</li><li>1.9. miRNAs and Stem Cells</li><li>1.10. Conclusions and Future Perspectives</li><li>Chapter Questions</li><li>Acronyms and Abbreviations</li></ul></li><li>Chapter 2. Control of Pluripotency and Reprogramming<ul><li>2.1. Introduction</li><li>2.2. Basic Properties of Stem Cells</li><li>2.3. Pluripotency</li><li>2.4. Nuclear Reprogramming</li><li>2.5. Conclusions</li><li>Chapter Questions</li><li>Acronyms and Abbreviations</li></ul></li><li>Chapter 3. Epigenetic Modification of MicroRNAs<ul><li>3.1. Introduction</li><li>3.2. The Epigenetic Landscape of a Healthy Cell</li><li>3.3. miRNAs and Epigenetic Regulation</li><li>3.4. A Generalized Model for Epigenetic Regulation of miRNAs in Determining Cell Fate</li><li>3.5. Epigenetic Modifications and Regenerative Medicine</li><li>3.6. Epigenetic Modifying Drugs</li><li>3.7. The Clinical Relevance of miRNAs and Epigenetic Modifying Drugs</li><li>3.8. Conclusions and Future Perspectives</li><li>Chapter Questions</li><li>Abbreviations</li></ul></li><li>Chapter 4. miRNAs in Bone Marrow–Derived Mesenchymal Stem Cells<ul><li>4.1. Introduction</li><li>4.2. Mechanisms of MSC Correction</li><li>4.3. miRNAs in General and in Wound Healing</li><li>4.4. MSC<span class="smallcaps">S</i> in miR-146A Expression: Attenuation of Inflammatory Response in Diabetic Wounds</li><li>4.5. Conclusions and Future Perspectives</li><li>Chapter Questions</li></ul></li><li>Chapter 5. miRNAs in Cancer Stem Cells<ul><li>5.1. Introduction</li><li>5.2.
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- © Academic Press 2015
- 23rd December 2014
- Academic Press
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Dr. Chandan K Sen is a tenured Professor of Surgery, Executive Director of The Ohio State University Comprehensive Wound Center and Director of the Ohio State University's Center for Regenerative Medicine & Cell Based Therapies. He is also the Associate Dean for Research at The Ohio State University Wexner Medical Center. After completing his Masters of Science in Human Physiology from the University of Calcutta, Dr. Sen received his PhD in Physiology from the University of Kuopio in Finland. Dr. Sen trained as a postdoctoral fellow at the University of California at Berkeley's Molecular and Cell Biology department. His first faculty appointment was in the Lawrence Berkeley National Laboratory in California. In fall of 2000, Dr. Sen moved to The Ohio State University where established a program on tissue injury and repair. Currently, Dr. Sen is a Professor and Vice Chair of Research of Surgery. Dr. Sen serves on the editorial board of numerous scientific journals. He is the Editor in Chief of Antioxidants & Redox Signaling(www.liebertpub.com/ars) with a current impact factor of 8.456. He is the Section Editor of microRNA of Physiological Genomics, a journal of the American Physiological Society. Dr. Sen and his team have published over 250 scientific publications. He has a H-index of 64 and is currently cited 2000 times every year.
The Ohio State University, Wexner Medical Center, Columbus, Ohio, USA
"...comprehensive in its discussion of regenerative medicine and the current knowledge about microRNA in tissue regeneration. Score: 68 - 2 Stars" --Doody's