MicroRNA in Regenerative Medicine

1st Edition

Print ISBN: 9780124055445
eBook ISBN: 9780124058583
Imprint: Academic Press
Published Date: 23rd December 2014
Page Count: 1288
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This work encapsulates the uses of miRNA across stem cells, developmental biology, tissue injury and tissue regeneration. In particular contributors provide focused coverage of methodologies, intervention and tissue engineering.

Regulating virtually all biological processes, the genome’s 1048 encoded microRNAs appear to hold considerable promise for the potential repair and regeneration of tissues and organs in future therapies. In this work, 50 experts address key topics of this fast-emerging field. Concisely summarizing and evaluating key findings emerging from fundamental research into translational application, they point to the current and future significance of clinical research in the miRNA area. Coverage encompasses all major aspects of fundamental stem cell and developmental biology, including the uses of miRNA across repair and regeneration, and special coverage of methodologies and interventions as they point towards organ and tissue engineering

Key Features

  • Multi-colour text layout with 150 colour figures to illustrate important findings
  • Take home messages encapsulate key lessons throughout text
  • Short chapters offer focused discussion and clear ‘voice’


Graduate students studying stem cell biology and regenerative and reparative medicine

Table of Contents

  • Dedication
  • <li>Part 1. Stem Cells<ul><li>Chapter 1. MicroRNA Biogenesis in Regenerative Medicine<ul><li>1.1. Introduction</li><li>1.2. Macro Impact of miRNAs</li><li>1.3. miRNA Biogenesis: Different Paths to the Same Destination</li><li>1.4. Mechanisms of miRNA-Induced Translational Repression</li><li>1.5. miRNA Regulation</li><li>1.6. Methods for miRNA Profiling</li><li>1.7. Bioinformatics Analysis of miRNAs</li><li>1.8. miRNA Applications in Regenerative Medicine</li><li>1.9. miRNAs and Stem Cells</li><li>1.10. Conclusions and Future Perspectives</li><li>Chapter Questions</li><li>Acronyms and Abbreviations</li></ul></li><li>Chapter 2. Control of Pluripotency and Reprogramming<ul><li>2.1. Introduction</li><li>2.2. Basic Properties of Stem Cells</li><li>2.3. Pluripotency</li><li>2.4. Nuclear Reprogramming</li><li>2.5. Conclusions</li><li>Chapter Questions</li><li>Acronyms and Abbreviations</li></ul></li><li>Chapter 3. Epigenetic Modification of MicroRNAs<ul><li>3.1. Introduction</li><li>3.2. The Epigenetic Landscape of a Healthy Cell</li><li>3.3. miRNAs and Epigenetic Regulation</li><li>3.4. A Generalized Model for Epigenetic Regulation of miRNAs in Determining Cell Fate</li><li>3.5. Epigenetic Modifications and Regenerative Medicine</li><li>3.6. Epigenetic Modifying Drugs</li><li>3.7. The Clinical Relevance of miRNAs and Epigenetic Modifying Drugs</li><li>3.8. Conclusions and Future Perspectives</li><li>Chapter Questions</li><li>Abbreviations</li></ul></li><li>Chapter 4. miRNAs in Bone Marrow&#x2013;Derived Mesenchymal Stem Cells<ul><li>4.1. Introduction</li><li>4.2. Mechanisms of MSC Correction</li><li>4.3. miRNAs in General and in Wound Healing</li><li>4.4. MSC<span class="smallcaps">S</i> in miR-146A Expression: Attenuation of Inflammatory Response in Diabetic Wounds</li><li>4.5. Conclusions and Future Perspectives</li><li>Chapter Questions</li></ul></li><li>Chapter 5. miRNAs in Cancer Stem Cells<ul><li>5.1. Introduction</li><li>5.2.


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"...comprehensive in its discussion of regenerative medicine and the current knowledge about microRNA in tissue regeneration.  Score: 68 - 2 Stars" --Doody's