Micro/Nanofluidics and Lab-on-Chip Based Emerging Technologies for Biomedical and Translational Research Applications - Part B

Micro/Nanofluidics and Lab-on-Chip Based Emerging Technologies for Biomedical and Translational Research Applications - Part B

1st Edition - January 28, 2022

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  • Editors: Alok Pandya, Vijai Singh
  • Hardcover ISBN: 9780323853033
  • eBook ISBN: 9780323853040

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Description

Micro/Nanofluidics and Lab-on-Chip Based Emerging Technologies for Biomedical and Translational Research Applications - Part B, Volume 187 represents the collation of chapters written by eminent scientists worldwide. Chapters in this new release include Design and fabrication of microfluidics devices for molecular biology applications, Micro/Nanofluidics devices for drug delivery, From organ-on-chip to body-on-chip: the next generation of microfluidics platforms for in vitro drug toxicity testing, Micro/Nanofluidics for high throughput drug screening, Design, fabrication and assembly of lab-on-a-chip and its uses, Advances in microfluidic 3D cell culture for pre-clinical drug development, Tissue and organ culture on lab-on-a chip for biomedical applications, and much more.

Key Features

  • Offers a basic understanding of the state-of-the-art design and fabrication of microfluidics/ nanofluidics and lab on chip
  • Explains how to develop microfluidics/nanofluidic for advanced application such as healthcare, high throughout drug screening, 3D cell culture and organ-on-chip
  • Discusses the emerging demands and research of micro/nanofluidic based devices in biomedical and translational research applications

Readership

Researchers in microfluidics/ nanofluidic, Biological engineering, Material science, Health Sciences, Translational Science, Nanotechnology, Pharmaceutical sciences and biomedical engineering, Students, Clinician, Stake holders and many more

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Contributors
  • Preface
  • Chapter One: Design and fabrication of microfluidics devices for molecular biology applications
  • Abstract
  • 1: Introduction
  • 2: Design and fabrication of microfluidics chip
  • 3: Microfluidics for extraction of nucleic acids
  • 4: Microfluidics for detection of nucleic acids
  • 5: Microfluidics devices for detection of metabolites and toxins
  • 6: Conclusion and future remarks
  • Acknowledgments
  • References
  • Chapter Two: Micro/nanofluidic devices for drug delivery
  • Abstract
  • 1: Microfluidic in vitro drug delivery at the cellular level
  • 2: Microfluidic in vitro drug delivery at tissue level
  • 3: Microfluidic in situ drug delivery at organ level
  • 4: Conclusion and future perspective
  • References
  • Chapter Three: From organ-on-chip to body-on-chip: The next generation of microfluidics platforms for in vitro drug efficacy and toxicity testing
  • Abstract
  • 1: Introduction
  • 2: Organ-on-chip development: The game changer
  • 3: Interconnected organ-on-chips: The emergence of body-on-chips
  • 4: Advantages and limitations of OOCs and BOCs
  • 5: Conclusion
  • References
  • Chapter Four: Micro and nanofluidics for high throughput drug screening
  • Abstract
  • 1: Introduction
  • 2: State of the art in micro and nanofluidics
  • 3: Current and recent development in high throughput systems
  • 4: Micro and nanofluidics for high throughput in diagnostics application
  • 5: Micro and nanofluidics for high throughput drug screening
  • 6: Micro and nanofluidics for tuberculosis diagnostics
  • 7: Future perspectives
  • Acknowledgments
  • References
  • Chapter Five: Design, fabrication and assembly of lab-on-a-chip and its uses
  • Abstract
  • 1: Point of care diagnostics
  • 2: Fabrication of lab-on-a-chip devices
  • 3: Assembly of a lab-on-a-chip device
  • 4: Applications
  • 5: Conclusion
  • References
  • Chapter Six: Advances in microfluidic 3D cell culture for preclinical drug development
  • Abstract
  • 1: Introduction
  • 2: Materials and microfabrication methods
  • 3: Microfluidic hydrogels and coating methods as extracellular matrix mimics
  • 4: From microfluidic 3D cell culture to functional tissues and organs
  • 5: Microfluidic 3D cell culture for drug development
  • 6: Concluding remarks
  • References
  • Further reading
  • Chapter Seven: Cultivating human tissues and organs over lab-on-a-chip models: Recent progress and applications
  • Abstract
  • 1: Introduction
  • 2: Traditional cell culture techniques
  • 3: Emerging organ/tissue-on-chip techniques
  • 4: Organ-on-chip and associated biomedical applications
  • 5: Organ-on-chip and nanomedicine
  • 6: Limitations
  • 7: Conclusion and future aspect
  • References
  • Chapter Eight: Microfluidics based point-of-care for disease diagnostics
  • Abstract
  • 1: Introduction
  • 2: Microfluidics based point-of-care for infectious disease diagnosis
  • 3: Microfluidics-based point-of-care for disease diagnostics
  • 4: Conclusion and future remarks
  • Acknowledgments
  • References
  • Chapter Nine: Lab on a body for biomedical electrochemical sensing applications: The next generation of microfluidic devices
  • Abstract
  • 1: Introduction
  • 2: Concepts of on-body microfluidic sensing devices
  • 3: Challenges when developing on-body microfluidic sensing devices
  • 4: Advances of microfluidic components toward the development of on-body microfluidic devices
  • 5: Examples of on-body microfluidic devices integrated electrochemical sensors for diagnosis
  • 6: Conclusion and prospects
  • References
  • Chapter Ten: Microfluidic tools for veterinary and zoonotic disease diagnostics
  • Abstract
  • 1: Introduction
  • 2: Types of microfluidic tools
  • 3: Applications of microfluidics in veterinary diagnostics
  • 4: Conclusion and future perspective
  • Acknowledgments
  • References
  • Chapter Eleven: Continuous monitoring of molecular biomarkers in microfluidic devices
  • Abstract
  • 1: Introduction
  • 2: Techniques
  • 3: Conclusions
  • References
  • Chapter Twelve: Microfluidics device for drug discovery, screening and delivery
  • Abstract
  • 1: Introduction
  • 2: Microfluidics for drug discovery and screening
  • 3: Microfluidics for drug delivery
  • 4: Droplet microfluidics platforms
  • 5: Droplet microfluidics for drug discovery, screening and delivery
  • 6: Conclusion and future remarks
  • Acknowledgments
  • References
  • Index

Product details

  • No. of pages: 368
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: January 28, 2022
  • Imprint: Academic Press
  • Hardcover ISBN: 9780323853033
  • eBook ISBN: 9780323853040

About the Serial Volume Editors

Alok Pandya

Alok Pandya
Dr. Alok Pandya is an Interdisciplinary Researcher and Assistant Professor at Department of Engineering and Physical Sciences, Institute of Advanced Research (IAR), Gandhinagar, Gujarat, India. His research work is broadly focused on nanobiotechnology, nanochemistry, and forensic nanotechnology. He has completed his PhD from Gujarat University and awarded with GSA-CHARUSAT Best thesis award for development of various high sensitive nanoassemblies to detect metal ion, non-metal ion, biomolecule and illicit drugs in a forensic context. Later, He joined as Post-Doctoral Research Associate (2013-16) and Young Scientist (2016-17) at Division of biological Sciences, Ahmedabad University, Gujarat, India for development of point of care prognostic kit for cardiac specific biomarker using lateral flow immunoassay. In 2016, he received a first prestigious independent SERB- Young Scientist project to design and development of nanodevice for early detection of multiple cardiac specific biomarker. He has indigenously developed a vertical flow immunoassay-based immunokit for detection CRP and H-FABP. As a reflection, he received multiple translational projects from high repute funding agencies such as SERB-OPDF(Australia), DST, SERB & GSBTM. Currently, his significant research focuses on the development of affordable nanodevice for disease monitoring, agricultural nano-products, and products for societal use. He has published more than 52+ articles in high repute international Journals and published 2 full provisional Indian patent. In addition, he has published 10+ book chapters in the international publishing agency. He has published a 3 books entitled as Introduction of forensic nanotechnology as future armour (Nova Science Publisher USA), Micro/ nanofluidics and lab-on-chip based emerging technologies for biomedical and translational research applications, Volume 186 and volume 187 (Elsevier publications, Netherlands). He is also editor of journal of current nano-toxicology and prevention, Bentham Science Publisher. He has over 9+ Years’ experience of teaching in various subjects such as spectroscopy, nano-chemistry, nanobiotechnology, nano-biosensor, biochemistry, and forensic nanotechnology. He is also IAR placement cell and industrial relations coordinator, member secretary of IAR-student startup and innovation policy, Govt. of Gujarat, member secretary of IAR- Institution innovation council.

Affiliations and Expertise

Assistant Professor, Department of Engineering and Physical Sciences, Institute of Advanced Research, Gandhinagar, Gujarat, India

Vijai Singh

Dr Vijai Singh is an Associate Professor and Dean (Research & Innovation) at School of Sciences, Indrashil University, Rajpur, Mehsana, Gujarat, India. He was an Assistant Professor in the Department of Biological Sciences and Biotechnology at the Institute of Advanced Research, Gandhinagar, India and also an Assistant Professor in the Department of Biotechnology at the Invertis University, Bareilly, India. Prior to that, he was a Postdoctoral Fellow in the Synthetic Biology Group at the Institute of Systems and Synthetic Biology, Paris, France and School of Energy & Chemical Engineering at the Ulsan National Institute of Science and Technology, Ulsan, South Korea. He received his Ph.D. in Biotechnology (2009) from the National Bureau of Fish Genetic Resources, Uttar Pradesh Technical University, Lucknow, India with a research focus on the development of molecular and immunoassays for diagnosis of Aeromonas hydrophila. His research interests are focused on design of a novel biosynthetic pathways for production of medically and industrially important biomolecules. Additionally, his laboratory focuses on development and implementation of CRISPR-Cas systems for genome editing, regulation and diagnosis. His laboratory is supported by projects from Government of India and industry. He has more than 10 years of research and teaching experience in synthetic biology, metabolic engineering, bioinformatics, microbiology, and industrial microbiology. He has published 79 articles, 51 chapters, 15 books and 4 patents. He serves as an associate editor, editorial board member, and reviewer of several peer-reviewed journals. He is also a member of the Board of Study and Academic Council of Indrashil University and is the Member Secretary of the Institutional Biosafety Committee (IBSC) at the same University.

Affiliations and Expertise

Associate Professor and Dean (Research & Innovation) at School of Sciences, Indrashil University, Rajpur, Mehsana, Gujarat, India.

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