Micro/Nanofluidics and Lab-on-Chip Based Emerging Technologies for Biomedical and Translational Research Applications - Part A

Micro/Nanofluidics and Lab-on-Chip Based Emerging Technologies for Biomedical and Translational Research Applications - Part A

1st Edition - January 13, 2022

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  • Editors: Alok Pandya, Vijai Singh
  • eBook ISBN: 9780323989008
  • Hardcover ISBN: 9780323988995

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Micro/Nanofluidics and Lab-on-Chip Based Emerging Technologies for Biomedical and Translational Research Applications, Volume 185, Part A represents the collation of chapters written by eminent scientists worldwide. Chapters in this updated release include An introduction to microfluidics and their applications, Design and fabrication of Micro/Nanofluidics devices and systems, Detection and separation of proteins using Micro/Nanofluidics devices, Micro/Nanofluidics devices for DNA/RNA detection and separation, Paper based microfluidics a forecast towards the most affordable and rapid point-of-care devices, Paper based micro/Nanofluidics devices for biomedical applications, Advances of Microfluidics Devices and their Applications in Personalized Medicine, and much more. Additional chapters cover Microfluidics for single cell analysis, Fluorescence Based Miniaturized Microfluidic and Nanofluidic Systems for Biomedical Applications, Active Matter Dynamics in Confined Microfluidic Environments, Challenges and opportunities in micro/nanofluidics and lab-on-a-chip, and Paper-microfluidic signal-enhanced immunoassays.

Key Features

  • Offers basic understanding of the state-of-the-art design and fabrication of microfluidics/ nanofluidics and lab-on-chip
  • Explains how to develop microfluidics/nanofluidics for biomedical application such as high throughout biological screening and separation
  • Discusses the applications, challenges and opportunities in biomedical and translational research applications of microfluidics/nanofluidics


Researchers in microfluidics/ nanofluidic, Biological engineering, Material science, Health Sciences, Translational Science, Nanotechnology, Pharmaceutical sciences and biomedical engineering, Students, Clinician, Stake holders and many more

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Contributors
  • Preface
  • Chapter One: An introduction to microfluidics and their applications
  • Abstract
  • 1: Introduction
  • 2: Type of micro/nanofluidics
  • 3: Design and fabrication of microfluidics devices
  • 4: Paper based microfluidics
  • 5: Application of microfluidics devices
  • 6: Conclusion and future remarks
  • Acknowledgments
  • Chapter Two: Design and fabrication of micro/nanofluidics devices and systems
  • Abstract
  • 1: Introduction
  • 2: Theory of micro/nanofluidics
  • 3: Fabrication of micro/nanofluidic devices
  • 4: Design thinking approach for micro/nanofluidics
  • 5: Outlook
  • Chapter Three: Detection and separation of proteins using micro/nanofluidics devices
  • Abstract
  • 1: Introduction
  • 2: Protein separation using microfluidics system/devices
  • 3: Conclusion
  • Chapter Four: Micro/nanofluidic devices for DNA/RNA detection and separation
  • Abstract
  • 1: Introduction
  • 2: Separation of nucleic acid using NF and MF
  • 3: Detection of nucleic acid using NF and MF using different fabrication techniques
  • 4: Future prospects
  • Acknowledgments
  • Chapter Five: Paper based microfluidics: A forecast toward the most affordable and rapid point-of-care devices
  • Abstract
  • 1: Introduction and historical perspective of paper-based microfluidic devices
  • 2: Fabrication methods
  • 3: Fluid flow control and liquid handling
  • 4: Applications of paper-based microfluidic devices
  • 5: Current limitations and future works
  • 6: Conclusion and final thoughts
  • Acknowledgment
  • Chapter Six: Paper based micro/nanofluidics devices for biomedical applications
  • Abstract
  • 1: Importance of paper as a diagnostic device
  • 2: Paper as a sample pretreatment platform in clinical diagnosis
  • 3: Paper microfluidic diagnostic devices
  • 4: Dipstick paper biosensors
  • 5: Lateral flow assay (LFA)
  • 6: MicroPAD (μPAD)
  • 7: Fabrications of paper microfluidics
  • 8: Detection techniques
  • 9: Readout devices
  • 10: Biomedical applications
  • 11: Paper nanofluidics
  • 12: Challenges and research gaps
  • 13: Conclusions
  • 14: Future outlook
  • Acknowledgment
  • Chapter Seven: Advances in microfluidics devices and its applications in personalized medicines
  • Abstract
  • 1: Introduction
  • 2: Microfluidics for cancer theranostics
  • 3: Microfluidics for detection of cardiovascular diseases
  • 4: Microfluidics for detection of diabetes
  • 5: Microfluidics for detection of pulmonary disease and therapy
  • 6: Conclusion and future perspectives
  • Acknowledgments
  • Chapter Eight: Microfluidics for single cell analysis
  • Abstract
  • 1: Introduction
  • 2: Design and fabrication of microfluidics devices and chips
  • 3: Droplets-based single cell analysis and their applications
  • 4: Use of microfluidics devices for single cell analysis
  • 5: Conclusion and future remarks
  • Acknowledgments
  • Chapter Nine: Fluorescence based miniaturized microfluidic and nanofluidic systems for biomedical applications
  • Abstract
  • 1: Introduction
  • 2: Microfluidic systems for biomedical applications
  • 3: Nanofluidic systems for biomedical applications
  • 4: Conclusion and future prospects
  • Acknowledgments
  • Chapter Ten: Active matter dynamics in confined microfluidic environments
  • Abstract
  • Chapter Eleven: Paper-microfluidic signal-enhanced immunoassays
  • Abstract
  • 1: Introduction and the history of paper-based immunoassays
  • 2: Classification of signal enhancement strategies used in paper-based immunoassays
  • 3: SWOT analysis: Paper-based immunoassays
  • Chapter Twelve: Challenges and opportunities in micro/nanofluidic and lab-on-a-chip
  • Abstract
  • 1: Understand micro/nanofluidic (MF/NF)
  • 2: Understand lab-on-a-chip
  • 3: Challenges in designing micro/nanofluidic
  • 4: Challenges in designing lab-on-a-chip device
  • 5: Opportunities in micro/nanofluidic and lab-on-a-chip devices
  • Acknowledgments
  • Index

Product details

  • No. of pages: 326
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: January 13, 2022
  • Imprint: Academic Press
  • eBook ISBN: 9780323989008
  • Hardcover ISBN: 9780323988995

About the Serial Volume Editors

Alok Pandya

Alok Pandya
Dr. Alok Pandya is an Interdisciplinary Researcher and Assistant Professor at Department of Engineering and Physical Sciences, Institute of Advanced Research (IAR), Gandhinagar, Gujarat, India. His research work is broadly focused on nanobiotechnology, nanochemistry, and forensic nanotechnology. He has completed his PhD from Gujarat University and awarded with GSA-CHARUSAT Best thesis award for development of various high sensitive nanoassemblies to detect metal ion, non-metal ion, biomolecule and illicit drugs in a forensic context. Later, He joined as Post-Doctoral Research Associate (2013-16) and Young Scientist (2016-17) at Division of biological Sciences, Ahmedabad University, Gujarat, India for development of point of care prognostic kit for cardiac specific biomarker using lateral flow immunoassay. In 2016, he received a first prestigious independent SERB- Young Scientist project to design and development of nanodevice for early detection of multiple cardiac specific biomarker. He has indigenously developed a vertical flow immunoassay-based immunokit for detection CRP and H-FABP. As a reflection, he received multiple translational projects from high repute funding agencies such as SERB-OPDF(Australia), DST, SERB & GSBTM. Currently, his significant research focuses on the development of affordable nanodevice for disease monitoring, agricultural nano-products, and products for societal use. He has published more than 52+ articles in high repute international Journals and published 2 full provisional Indian patent. In addition, he has published 10+ book chapters in the international publishing agency. He has published a 3 books entitled as Introduction of forensic nanotechnology as future armour (Nova Science Publisher USA), Micro/ nanofluidics and lab-on-chip based emerging technologies for biomedical and translational research applications, Volume 186 and volume 187 (Elsevier publications, Netherlands). He is also editor of journal of current nano-toxicology and prevention, Bentham Science Publisher. He has over 9+ Years’ experience of teaching in various subjects such as spectroscopy, nano-chemistry, nanobiotechnology, nano-biosensor, biochemistry, and forensic nanotechnology. He is also IAR placement cell and industrial relations coordinator, member secretary of IAR-student startup and innovation policy, Govt. of Gujarat, member secretary of IAR- Institution innovation council.

Affiliations and Expertise

Assistant Professor, Department of Engineering and Physical Sciences, Institute of Advanced Research, Gandhinagar, Gujarat, India

Vijai Singh

Dr Vijai Singh is an Associate Professor and Dean (Research & Innovation) at School of Sciences, Indrashil University, Rajpur, Mehsana, Gujarat, India. He was an Assistant Professor in the Department of Biological Sciences and Biotechnology at the Institute of Advanced Research, Gandhinagar, India and also an Assistant Professor in the Department of Biotechnology at the Invertis University, Bareilly, India. Prior to that, he was a Postdoctoral Fellow in the Synthetic Biology Group at the Institute of Systems and Synthetic Biology, Paris, France and School of Energy & Chemical Engineering at the Ulsan National Institute of Science and Technology, Ulsan, South Korea. He received his Ph.D. in Biotechnology (2009) from the National Bureau of Fish Genetic Resources, Uttar Pradesh Technical University, Lucknow, India with a research focus on the development of molecular and immunoassays for diagnosis of Aeromonas hydrophila. His research interests are focused on design of a novel biosynthetic pathways for production of medically and industrially important biomolecules. Additionally, his laboratory focuses on development and implementation of CRISPR-Cas systems for genome editing, regulation and diagnosis. His laboratory is supported by projects from Government of India and industry. He has more than 10 years of research and teaching experience in synthetic biology, metabolic engineering, bioinformatics, microbiology, and industrial microbiology. He has published 79 articles, 51 chapters, 15 books and 4 patents. He serves as an associate editor, editorial board member, and reviewer of several peer-reviewed journals. He is also a member of the Board of Study and Academic Council of Indrashil University and is the Member Secretary of the Institutional Biosafety Committee (IBSC) at the same University.

Affiliations and Expertise

Indrashil University, Gujarat, India

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